UniProtKB - R4GCA5 (R4GCA5_ANOCA)
Protein
Protein kinase domain-containing protein
Gene
IRAK1
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: InterPro
GO - Biological processi
- interleukin-1-mediated signaling pathway Source: InterPro
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase domain-containing proteinInterPro annotation |
Gene namesi | Name:IRAK1Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Expressioni
Gene expression databases
Bgeei | ENSACAG00000012475, Expressed in lung and 13 other tissues |
ExpressionAtlasi | R4GCA5, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 213 – 512 | Protein kinaseInterPro annotationAdd BLAST | 300 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 95 – 191 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 612 – 634 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 110 – 125 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 150 – 164 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 169 – 191 | PolarSequence analysisAdd BLAST | 23 |
Phylogenomic databases
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
OrthoDBi | 684563at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
R4GCA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGSRSPRFL YELPASVMCH FYEIMDALGR EEWQRFASRI VRDQVELRLY
60 70 80 90 100
ERMEAPTSKV MWAWMNRNAR VSDLLQILDD LQLYRAHNVI ASWNPPSRPV
110 120 130 140 150
ESRAVPCPQS SVPLDPPPPL PAPDPGGRVG VGSSKVKNAM WEPQKGQSPS
160 170 180 190 200
VPEPFSPPLS LPEPAPNRCL SSMDQNSMRS PSTKPDEQGL SSLSLTCPFE
210 220 230 240 250
WRLEELRQAT SDFSENLKIG EGGFGCVYQA RLRNTIYAVK RLKEEAELDW
260 270 280 290 300
SVIKNSFVTE VEKLYRFRHP NIVELAGYCA EQGNFCLVYV FLPKGSLDDH
310 320 330 340 350
LHRQVGPCLT WSQRLHVAVG TSRAIQFLHS DSPSLIHGDV KSSNILLDAA
360 370 380 390 400
LNPRLADFGL ARFSRRPKQG TMSSSLGRTQ TVQGTLAYLP PEYVRTGTLS
410 420 430 440 450
TAIDVFSFGV VLLELLTGRR PMEVDSCGHS KYLKDLLSEE EEAQHTPTTM
460 470 480 490 500
TSSSSQAAQL GTSLYQKHMD LQAGPCPELL GIMIGRLACQ CLHPRAKRRP
510 520 530 540 550
PMAEVYQELE RLQLSLYGES SDSLLPSRQL HTTQENLFPA RHLNQPQEID
560 570 580 590 600
ERQVAGFDLV SQRSVPRGNV SGGQPDASAP QIIINPARRR MMERLALYRD
610 620 630
GMLDSLAVLA SAPSVSEPIA QPSREPEESD EFES
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG1KMD9 | G1KMD9_ANOCA | Protein kinase domain-containing pr... | IRAK1 | 679 | Annotation score: |
Sequence databases
RefSeqi | XP_008102119.1, XM_008103912.2 |
Genome annotation databases
Ensembli | ENSACAT00000030383; ENSACAP00000022964; ENSACAG00000012475 |
GeneIDi | 100563977 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008102119.1, XM_008103912.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSACAT00000030383; ENSACAP00000022964; ENSACAG00000012475 |
GeneIDi | 100563977 |
Organism-specific databases
CTDi | 3654 |
Phylogenomic databases
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
OrthoDBi | 684563at2759 |
Gene expression databases
Bgeei | ENSACAG00000012475, Expressed in lung and 13 other tissues |
ExpressionAtlasi | R4GCA5, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R4GCA5_ANOCA | |
Accessioni | R4GCA5Primary (citable) accession number: R4GCA5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | October 7, 2020 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |