UniProtKB - R4GCA1 (R4GCA1_ANOCA)
Protein
Citrate synthase
Gene
CS
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.ARBA annotationProteins known to be involved in the 2 steps of the subpathway in this organism are:
- Citrate synthase (CS), Citrate synthase (CS)
- Aconitate hydratase, mitochondrial (aco2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
GO - Molecular functioni
- citrate (Si)-synthase activity Source: InterPro
GO - Biological processi
- citrate metabolic process Source: InterPro
- tricarboxylic acid cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | TransferaseUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Names & Taxonomyi
Protein namesi | Recommended name: Citrate synthaseUniRule annotation |
Gene namesi | Name:CSImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion matrix ARBA annotation
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSACAG00000007556, Expressed in hemipenis and 14 other tissues |
Interactioni
Subunit structurei
Homodimer.
ARBA annotationFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 403 – 427 | DisorderedSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00390000006813 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
R4GCA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLLTASSRA AARLLGAKNS SCIIFAARHA SASTNLKDVL ANMIPKEQAR
60 70 80 90 100
LKSFRQQYGS TVIGQITVDM LYGGMRGMKG LIYETSVLDP DEGIRFRGYS
110 120 130 140 150
IPECQKLLPK APGGAEPLPE GLFWLLVTGE IPSQEQVSWL SREWAKRAAL
160 170 180 190 200
PSHVVTMLDN FPTNLHPMSQ LSAAVTALNS ESTFARAYSE GISRTKYWEF
210 220 230 240 250
IYEDSMDLIA KLPCIAAKIY RNLYREGSSI GAIDPALDWS HNFTNMLGYN
260 270 280 290 300
DPQFIELMRL YLTIHSDHEG GNVSAHTSHL VGSALSDPYL SFAAAMNGLA
310 320 330 340 350
GPLHGLANQE VLVWLTSLQK ELGEDVSDEK LRDFIWNTLN SGRVVPGYGH
360 370 380 390 400
AVLRKTDPRY TCQREFALKH LPKDPLFKLV AQLYKIVPNV LLEQGKAKNP
410 420
WPNVDAHSGV LLQGRGKPSE SGKTNNQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG1KGV0 | G1KGV0_ANOCA | Citrate synthase | CS | 462 | Annotation score: |
Genome annotation databases
Ensembli | ENSACAT00000030379; ENSACAP00000022960; ENSACAG00000007556 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSACAT00000030379; ENSACAP00000022960; ENSACAG00000007556 |
Phylogenomic databases
GeneTreei | ENSGT00390000006813 |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
Gene expression databases
Bgeei | ENSACAG00000007556, Expressed in hemipenis and 14 other tissues |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R4GCA1_ANOCA | |
Accessioni | R4GCA1Primary (citable) accession number: R4GCA1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |