UniProtKB - R4GC74 (R4GC74_ANOCA)
Protein
Tripeptidyl-peptidase 2
Gene
TPP2
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
- tripeptidyl-peptidase activity Source: GO_Central
Keywordsi
Molecular function | AminopeptidaseARBA annotation, Hydrolase, Protease, Serine proteaseARBA annotation |
Protein family/group databases
MEROPSi | S08.A56 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TPP2Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nuclear body Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSACAG00000002987, Expressed in skeletal muscle tissue and 14 other tissues |
ExpressionAtlasi | R4GC74, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 500 | Peptidase_S8InterPro annotationAdd BLAST | 466 | |
Domaini | 784 – 970 | TPPIIInterPro annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1017 – 1036 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1080 – 1103 | Sequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1021 – 1036 | PolyampholyteSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG1114, Eukaryota |
GeneTreei | ENSGT00390000014623 |
OrthoDBi | 156304at2759 |
Family and domain databases
CDDi | cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit |
Gene3Di | 3.40.50.200, 2 hits |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR022229, Peptidase_S8A_TPPII IPR034051, TPP_II_domain |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF12580, TPPII, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
R4GC74-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGAVEDPF PFQGLLPKKE TGAAAFLSRH PEYDGRGVLV AILDTGVDPG
60 70 80 90 100
APGMQITTDG KPKIIDIIDT TGSGDVNTST IVEVKDGEII GLSGKTLKIP
110 120 130 140 150
TDWINPSGKY HIGLKNGYDF YPKALKERIQ KERKEKLWDP VHRLALTEAC
160 170 180 190 200
RRQDEFEAAH VSPSQESKLM KEELQTQVEL LNSFEKKYSD PGPVYDCLVW
210 220 230 240 250
HDGETWRACI DASESCDFPN CTVLRNYREA QEYGSFGTSE MLNYSVNIYD
260 270 280 290 300
EGNLLSIVTS GGSHGTHVAS IAAGHFPDEP DRNGVAPGAQ ILAIKIGDTR
310 320 330 340 350
LSTMETGTGL IRAMIETIKY KCDLVNYSYG EATHWPNAGR ICEVINEAVW
360 370 380 390 400
KHNVIYVSSA GNNGPCLSTV GCPGGTTNSV IGVGAYVSPD MMVAEYSLRE
410 420 430 440 450
KLPANQYTWS SRGPSTDGAL GVSISAPGGA IASVPNWTLR GTQLMNGTSM
460 470 480 490 500
SSPNACGGIA LVLSGLKANG VHYTVHSVRR ALENTAVKVE NIQVFAQGHG
510 520 530 540 550
IIQVDKAYDY LIQNTSFANS IGFTVTVGNN RGIYLRDPCQ VAAPSDHGVG
560 570 580 590 600
IEPFFPENTE NADRISLQLH LALTSNASWV QCPTHLELMN QCRHINIRVD
610 620 630 640 650
PRGLREGVHY TEVCGYEISM PNAGPLFRVP ITVVIPTRTD YASHYDLKFT
660 670 680 690 700
DVHFKPGQIQ RHFIEVPSGA TWAEVTVHSS SSDVTAKFVL HAVQLVKQKA
710 720 730 740 750
YRSHEFYKFS SIPEKGSISE AFPILDGRTI EFCIARWWAS LNDVSIDYTI
760 770 780 790 800
SFHGIVCTTS GIVCTTSQLN IHASEGIVRF DVQSTLRYED IAPSINLKSW
810 820 830 840 850
VQTLRPLSAK IKPLGSRDVL PNNRQLYEMI LTYSFHQPKS GEVSPSCPLL
860 870 880 890 900
CELLYESEYD SQLWMLFDQN KKLMGSGDAY PHQYTVKLEK GDYTIRLQIR
910 920 930 940 950
HEQNSELERI KDLPFIVTHR LSSVLSLEIY ESYSQALLGK KKANSMSLPP
960 970 980 990 1000
RHSQPFFATT FPDDKVPKGA NPGCYLAGSL TLSKTELGKK AGQSAAKRQG
1010 1020 1030 1040 1050
KFKKDIISVH YHLIPSPIKS KNGSKEKEKD ADKEKDAKEE FIEALRDLKI
1060 1070 1080 1090 1100
QWMTKLDTSD IYNELKEAFP NHLPLYVARL HQLDSEKERM KRLNEVVEAA
1110 1120 1130 1140 1150
NTVISHIDQT ALAVYLAMKT DPRPDAATIK NDMEKQKSTL VDALCRKGSA
1160 1170 1180 1190 1200
LADQLLQLQA QEGAGSSDAE CKDDSQDSGF NALMETFWET TKWTELTDTK
1210 1220 1230 1240 1250
VLPFAYKHAL VNKMYGRGLK FATKLVEEKP TKENLKNCIQ LMKLLGWTHC
1260
ASFTENWLPV MYPPDYCVF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG1KBP3 | G1KBP3_ANOCA | Tripeptidyl-peptidase 2 | TPP2 | 1,250 | Annotation score: |
Sequence databases
RefSeqi | XP_003218763.1, XM_003218715.3 |
Genome annotation databases
Ensembli | ENSACAT00000030350; ENSACAP00000022931; ENSACAG00000002987 |
GeneIDi | 100552517 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_003218763.1, XM_003218715.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000022931 |
Protein family/group databases
MEROPSi | S08.A56 |
Genome annotation databases
Ensembli | ENSACAT00000030350; ENSACAP00000022931; ENSACAG00000002987 |
GeneIDi | 100552517 |
Organism-specific databases
CTDi | 7174 |
Phylogenomic databases
eggNOGi | KOG1114, Eukaryota |
GeneTreei | ENSGT00390000014623 |
OrthoDBi | 156304at2759 |
Gene expression databases
Bgeei | ENSACAG00000002987, Expressed in skeletal muscle tissue and 14 other tissues |
ExpressionAtlasi | R4GC74, baseline |
Family and domain databases
CDDi | cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit |
Gene3Di | 3.40.50.200, 2 hits |
InterProi | View protein in InterPro IPR000209, Peptidase_S8/S53_dom IPR036852, Peptidase_S8/S53_dom_sf IPR022398, Peptidase_S8_His-AS IPR023828, Peptidase_S8_Ser-AS IPR015500, Peptidase_S8_subtilisin-rel IPR022229, Peptidase_S8A_TPPII IPR034051, TPP_II_domain |
Pfami | View protein in Pfam PF00082, Peptidase_S8, 1 hit PF12580, TPPII, 1 hit |
PRINTSi | PR00723, SUBTILISIN |
SUPFAMi | SSF52743, SSF52743, 1 hit |
PROSITEi | View protein in PROSITE PS00137, SUBTILASE_HIS, 1 hit PS00138, SUBTILASE_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R4GC74_ANOCA | |
Accessioni | R4GC74Primary (citable) accession number: R4GC74 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | August 12, 2020 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |