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UniProtKB - R4GC74 (R4GC74_ANOCA)

Entry version 48 (12 Aug 2020)
Sequence version 1 (26 Jun 2013)
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Protein

Tripeptidyl-peptidase 2

Gene

TPP2

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidaseARBA annotation, Hydrolase, Protease, Serine proteaseARBA annotation

Protein family/group databases

MEROPS protease database

More...MEROPSi		S08.A56

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripeptidyl-peptidase 2ARBA annotation (EC:3.4.14.10ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSACAG00000002987, Expressed in skeletal muscle tissue and 14 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		R4GC74, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		28377.ENSACAP00000022931

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 500Peptidase_S8InterPro annotationAdd BLAST466
Domaini784 – 970TPPIIInterPro annotationAdd BLAST187

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1017 – 1036DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1080 – 1103Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1021 – 1036PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1114, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014623

Database of Orthologous Groups

More...OrthoDBi		156304at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.200, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR022229, Peptidase_S8A_TPPII
IPR034051, TPP_II_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00082, Peptidase_S8, 1 hit
PF12580, TPPII, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00723, SUBTILISIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52743, SSF52743, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

R4GC74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGAVEDPF PFQGLLPKKE TGAAAFLSRH PEYDGRGVLV AILDTGVDPG 
        60         70         80         90        100
APGMQITTDG KPKIIDIIDT TGSGDVNTST IVEVKDGEII GLSGKTLKIP 
       110        120        130        140        150
TDWINPSGKY HIGLKNGYDF YPKALKERIQ KERKEKLWDP VHRLALTEAC 
       160        170        180        190        200
RRQDEFEAAH VSPSQESKLM KEELQTQVEL LNSFEKKYSD PGPVYDCLVW 
       210        220        230        240        250
HDGETWRACI DASESCDFPN CTVLRNYREA QEYGSFGTSE MLNYSVNIYD 
       260        270        280        290        300
EGNLLSIVTS GGSHGTHVAS IAAGHFPDEP DRNGVAPGAQ ILAIKIGDTR 
       310        320        330        340        350
LSTMETGTGL IRAMIETIKY KCDLVNYSYG EATHWPNAGR ICEVINEAVW 
       360        370        380        390        400
KHNVIYVSSA GNNGPCLSTV GCPGGTTNSV IGVGAYVSPD MMVAEYSLRE 
       410        420        430        440        450
KLPANQYTWS SRGPSTDGAL GVSISAPGGA IASVPNWTLR GTQLMNGTSM 
       460        470        480        490        500
SSPNACGGIA LVLSGLKANG VHYTVHSVRR ALENTAVKVE NIQVFAQGHG 
       510        520        530        540        550
IIQVDKAYDY LIQNTSFANS IGFTVTVGNN RGIYLRDPCQ VAAPSDHGVG 
       560        570        580        590        600
IEPFFPENTE NADRISLQLH LALTSNASWV QCPTHLELMN QCRHINIRVD 
       610        620        630        640        650
PRGLREGVHY TEVCGYEISM PNAGPLFRVP ITVVIPTRTD YASHYDLKFT 
       660        670        680        690        700
DVHFKPGQIQ RHFIEVPSGA TWAEVTVHSS SSDVTAKFVL HAVQLVKQKA 
       710        720        730        740        750
YRSHEFYKFS SIPEKGSISE AFPILDGRTI EFCIARWWAS LNDVSIDYTI 
       760        770        780        790        800
SFHGIVCTTS GIVCTTSQLN IHASEGIVRF DVQSTLRYED IAPSINLKSW 
       810        820        830        840        850
VQTLRPLSAK IKPLGSRDVL PNNRQLYEMI LTYSFHQPKS GEVSPSCPLL 
       860        870        880        890        900
CELLYESEYD SQLWMLFDQN KKLMGSGDAY PHQYTVKLEK GDYTIRLQIR 
       910        920        930        940        950
HEQNSELERI KDLPFIVTHR LSSVLSLEIY ESYSQALLGK KKANSMSLPP 
       960        970        980        990       1000
RHSQPFFATT FPDDKVPKGA NPGCYLAGSL TLSKTELGKK AGQSAAKRQG 
      1010       1020       1030       1040       1050
KFKKDIISVH YHLIPSPIKS KNGSKEKEKD ADKEKDAKEE FIEALRDLKI 
      1060       1070       1080       1090       1100
QWMTKLDTSD IYNELKEAFP NHLPLYVARL HQLDSEKERM KRLNEVVEAA 
      1110       1120       1130       1140       1150
NTVISHIDQT ALAVYLAMKT DPRPDAATIK NDMEKQKSTL VDALCRKGSA 
      1160       1170       1180       1190       1200
LADQLLQLQA QEGAGSSDAE CKDDSQDSGF NALMETFWET TKWTELTDTK 
      1210       1220       1230       1240       1250
VLPFAYKHAL VNKMYGRGLK FATKLVEEKP TKENLKNCIQ LMKLLGWTHC 
      1260 
ASFTENWLPV MYPPDYCVF
Length:1,269
Mass (Da):140,752
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DBB365B2320FBAB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1KBP3G1KBP3_ANOCA
Tripeptidyl-peptidase 2
TPP2
1,250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_003218763.1, XM_003218715.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSACAT00000030350; ENSACAP00000022931; ENSACAG00000002987

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100552517

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003218763.1, XM_003218715.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi28377.ENSACAP00000022931

Protein family/group databases

MEROPSiS08.A56

Genome annotation databases

EnsembliENSACAT00000030350; ENSACAP00000022931; ENSACAG00000002987
GeneIDi100552517

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7174

Phylogenomic databases

eggNOGiKOG1114, Eukaryota
GeneTreeiENSGT00390000014623
OrthoDBi156304at2759

Gene expression databases

BgeeiENSACAG00000002987, Expressed in skeletal muscle tissue and 14 other tissues
ExpressionAtlasiR4GC74, baseline

Family and domain databases

CDDicd04857, Peptidases_S8_Tripeptidyl_Aminopeptidase_II, 1 hit
Gene3Di3.40.50.200, 2 hits
InterProiView protein in InterPro
IPR000209, Peptidase_S8/S53_dom
IPR036852, Peptidase_S8/S53_dom_sf
IPR022398, Peptidase_S8_His-AS
IPR023828, Peptidase_S8_Ser-AS
IPR015500, Peptidase_S8_subtilisin-rel
IPR022229, Peptidase_S8A_TPPII
IPR034051, TPP_II_domain
PfamiView protein in Pfam
PF00082, Peptidase_S8, 1 hit
PF12580, TPPII, 1 hit
PRINTSiPR00723, SUBTILISIN
SUPFAMiSSF52743, SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS00137, SUBTILASE_HIS, 1 hit
PS00138, SUBTILASE_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR4GC74_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R4GC74
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: August 12, 2020
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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