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Entry version 55 (02 Jun 2021)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

DOCK9

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri28377 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSACAG00000016608, Expressed in testis and 14 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 274PHInterPro annotationAdd BLAST108
Domaini632 – 810C2 DOCK-typeInterPro annotationAdd BLAST179
Domaini1605 – 2044DOCKERInterPro annotationAdd BLAST440

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni283 – 319DisorderedSequence analysisAdd BLAST37
Regioni1265 – 1295DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1927 – 1947Sequence analysisAdd BLAST21
Coiled coili2021 – 2041Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi283 – 299Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155972

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAQHIGH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697, C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR037809, C2_Dock-D
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR026796, DOCK9
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317, PTHR23317, 1 hit
PTHR23317:SF77, PTHR23317:SF77, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PF00169, PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

R4GBF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARTNSKNL KKELIIESPQ NAATVEAEVD SPVEVRAKPK LIEPIDYENV
60 70 80 90 100
IVQKKTQILN DALREMLLFP YDDFQTAILK RQHRYLCSTV PDNAEKEAQS
110 120 130 140 150
LFVTECIKTY NSDWHVVNYK FEDYSGEFRQ LPNKGTKLDK LPVHIYEVDE
160 170 180 190 200
EIDKDEDAAS LGSQKGGITK QGWLYKGNMN SAISVTMRSF KRRFFHLLQL
210 220 230 240 250
GDGSYNLNFY KDEKISKEPK GSIFLDSCMG VVQNNKVRRF AFELKMQDKS
260 270 280 290 300
SYLLAADSEA EMEEWIATLN KILQLNFEAA MQEKRNGDSH DDDEQGKMDS
310 320 330 340 350
SSSSLDFLPE NIKGSRDTDM KFKSENRVKL FALDPDAQKL DFSGIEPEIK
360 370 380 390 400
PFEEKFGKRI LVKCNDLSFN LQSCVAENEE GPTTNVEPFF ITLSLFDIKH
410 420 430 440 450
NRKISSDLHV DLNHNTVRHM LDNVAQQLAN GSSDGLYRIQ DVIPEIMLQY
460 470 480 490 500
PKQGIFSVTC PHPDIFLVAR IEKVLQGSVT HCAEPYMKSS DSSKVAQKVL
510 520 530 540 550
KNAKQACQRL GQYRMPFAWA ARTLFKDASG TLDKNARFSA LYKQDSNKLS
560 570 580 590 600
NEDLLKFLAD FRKPEKMAKL PVILGNLDIT IDNVSPDISN FVSSSYIPMK
610 620 630 640 650
QFENSTKAVV TFEVEEFVPC IPKHTQPFTI YNNHLYVYPK HLKYDSQKSF
660 670 680 690 700
AKARNIAVCI EFKDSDDEDS VPLKCIYGRP GGPIFTKQAF ATVLHHHQNP
710 720 730 740 750
EFYDEIKIEL PTQLHEKHHL LFTFYHVSCD SSSKGTTKKK DTVETLVGYS
760 770 780 790 800
WLQLLKDGRV VTNEQHIPVA VYLPSGYLSS QEPGTNKHSG PEVKWVDGGK
810 820 830 840 850
PLLKISTHLV STIYTQDQHL NNFFHYCQKT ESGAQALGAE LVKYLKSLHA
860 870 880 890 900
MEGHVMIAFL PTILNQLFRV LTRAAQEEVA VNVTRVIIHV VAQCHEEGLD
910 920 930 940 950
SYLRSYVKYA YKAEPYIASE YKTVHEELAK SMTAILKPSA DFLTSNKLLK
960 970 980 990 1000
YSWFFFEILI KSMAQHLLEN AKVKLLRNQR FPASYHHAVE TVVNMLMPHI
1010 1020 1030 1040 1050
TQKYKDNPEA SKNANHSLAV FIKRCFTFMD RGFVFKQINN YITFFTPGDP
1060 1070 1080 1090 1100
KTLFEFKFEF LRVVCNHEHY IPLNLPMLFG KGRIQRYQAF LSPTVGSYDT
1110 1120 1130 1140 1150
LLDLQLDYCL SDEFCKHHFL VGLLLREVGS ALQEFRDIRQ IAISVLKNLM
1160 1170 1180 1190 1200
IKHSFDDRYA SKIHQARIAT LYLPTFGLLV ENVHRIDVKD ISPFPINASS
1210 1220 1230 1240 1250
TSTKEESLTL PAANPLMTPQ KSVNTLDNNL HKDLFGAISG IASPYTSSTP
1260 1270 1280 1290 1300
NVNCVRNADS RGSLISTDSG NSLPERHSEK SNFLDKNQQT GPTGSSVVRC
1310 1320 1330 1340 1350
DKLDQNEIRS LLMCFLYILK SMSEDALFTY WNKASTSELM DFFTIAEVCL
1360 1370 1380 1390 1400
HQFQYMGKRY IASVRKISSL LGISVDNGYG HSEADVLHQS LLEANIATEV
1410 1420 1430 1440 1450
CLTILDTLSL FTMAFKNQLL ADHGHNPLMK KVFDVYLCFL QKNQSETALK
1460 1470 1480 1490 1500
HVFSALRSFI FKFPSTFYEG RADMCSALCY EILKCCNSKL SSIRTEASQL
1510 1520 1530 1540 1550
LYFLMRNNFD YTGKRSFVRT HLQVIISVSQ LIADVVGIGG TRFQQSLSII
1560 1570 1580 1590 1600
NNCANSDRLT KHTTFPPDVK DLTKRIRTVL MATAQMKEHE NDPEMLVDLQ
1610 1620 1630 1640 1650
YSLAKSYAST PELRKTWLDS MARIHVKNGD LSEAAMCYVH VTALVAEYLL
1660 1670 1680 1690 1700
RKGMFKQGCI SFRVITPNID EEASMMEDVG MQDVHFNEDV LMELLEQCAD
1710 1720 1730 1740 1750
GLWKAERYEL IADIYKLIIP IYEKRRDFER LAHLYDTLHR AYSKVTEVMH
1760 1770 1780 1790 1800
TGKRLLGTYF RVAFFGQQYQ FTDSETDVEG FFEDEDGKEY IYKEPKLTPL
1810 1820 1830 1840 1850
SEISQRLQKL YSDKFGSENV RMIQDSGKVN PKDLDSKYAY IQVTHVVPYF
1860 1870 1880 1890 1900
EEKELQERKT EFERNHNIRR FMFEMPFTQL GKRRGGVEEQ CKRRTILTAI
1910 1920 1930 1940 1950
HCFPYVKKRI PIMYQHHIDL NPIEVAIDEM SKKVAELRQL CSSVEVDMIK
1960 1970 1980 1990 2000
LQLKLQGSVS VQVNAGPLAY ARAFLDDTNT KRYPDNKVKL LKEVFRQFVE
2010 2020 2030 2040 2050
ACGQALEVNE RLIKEDQIEY QEEMKANYRE MTKELSEIMH EQITSAEEKA
2060 2070 2080
SVMPNSLHIF NAISGTPTST TVHGMPSSSS VA
Length:2,082
Mass (Da):238,146
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB82D32EB49DE900E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1KT24G1KT24_ANOCA
Uncharacterized protein
DOCK9
2,097Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSACAT00000030048; ENSACAP00000022631; ENSACAG00000016608

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSACAT00000030048; ENSACAP00000022631; ENSACAG00000016608

Phylogenomic databases

GeneTreeiENSGT00940000155972
OMAiCAQHIGH

Gene expression databases

BgeeiENSACAG00000016608, Expressed in testis and 14 other tissues

Family and domain databases

CDDicd08697, C2_Dock-D, 1 hit
Gene3Di1.20.58.740, 1 hit
1.25.40.410, 1 hit
2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037809, C2_Dock-D
IPR035892, C2_domain_sf
IPR027007, DHR-1_domain
IPR027357, DHR-2
IPR026791, DOCK
IPR026796, DOCK9
IPR010703, DOCK_C
IPR021816, DOCK_C/D_N
IPR043161, DOCK_C_lobe_A
IPR043162, DOCK_C_lobe_C
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR23317, PTHR23317, 1 hit
PTHR23317:SF77, PTHR23317:SF77, 1 hit
PfamiView protein in Pfam
PF06920, DHR-2, 1 hit
PF14429, DOCK-C2, 1 hit
PF11878, DUF3398, 1 hit
PF00169, PH, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51650, DHR_1, 1 hit
PS51651, DHR_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR4GBF5_ANOCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: R4GBF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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