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Protein

General transcription factor IIH subunit 4

Gene

EMIHUDRAFT_450287

Organism
Emiliania huxleyi (Pontosphaera huxleyi)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
ORF Names:EMIHUDRAFT_450287Imported
OrganismiEmiliania huxleyi (Pontosphaera huxleyi)Imported
Taxonomic identifieri2903 [NCBI]
Taxonomic lineageiEukaryotaHaptophyceaeIsochrysidalesNoelaerhabdaceaeEmiliania
Proteomesi
  • UP000013827 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 2 hits
PfamiView protein in Pfam
PF03849 Tfb2, 2 hits

Sequencei

Sequence statusi: Complete.

R1CUX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAADALVQ YLSSLPPVNL DRLYADSWVC HALLRALPPL ARLYVVRLAA
60 70 80 90 100
AHGSLPKALV DSWPARVREA AKRHEESMQQ LHLLRLVHRV PAAGSGQEQL
110 120 130 140 150
RLHEAFGAAM LDSLGQGPPG LADDASARHG KDKNMVGADE LERMGAAKWE
160 170 180 190 200
RLMSRVWKVL LAYTNFRLYA HSSSELRARV LRSFALLSYQ LPGLIVGSLT
210 220 230 240 250
RTSIQHAVDS GVDAAAIVAY LERNAHPLMA AQTPVLPETV VNQIHLWAKE
260 270 280 290 300
RSRMAADRCK LYDAFDSLRR FDEACTYARE IGAHLWSRRF PEERNLHKCS
310
LAVRAEAHGS MKSFLRAAA
Length:319
Mass (Da):35,421
Last modified:June 26, 2013 - v1
Checksum:i523AC490B5632591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB865188 Genomic DNA Translation: EOD26467.1
RefSeqiXP_005778896.1, XM_005778839.1

Genome annotation databases

EnsemblProtistsiEOD26467; EOD26467; EMIHUDRAFT_450287
GeneIDi17272013
KEGGiehx:EMIHUDRAFT_450287

Entry informationi

Entry nameiR1CUX6_EMIHU
AccessioniPrimary (citable) accession number: R1CUX6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: May 23, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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