UniProtKB - R0BTE9 (R0BTE9_9FIRM)
Protein
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Gene
mraY
Organism
[Clostridium] bolteae 90A9
Status
Functioni
First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotationARBA annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMPUniRule annotationARBA annotationEC:2.7.8.13UniRule annotationARBA annotation
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationARBA annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
GO - Molecular functioni
- phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-UniRule
- UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | TransferaseUniRule annotationImportedARBA annotation |
Biological process | Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationARBA annotation, Peptidoglycan synthesisUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | Recommended name: Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotationARBA annotation (EC:2.7.8.13UniRule annotationARBA annotation)Alternative name(s): UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotationARBA annotation |
Gene namesi | Name:mraYUniRule annotation ORF Names:HMPREF1085_00623Imported |
Organismi | [Clostridium] bolteae 90A9Imported |
Taxonomic identifieri | 997894 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Lachnospiraceae › Enterocloster › |
Proteomesi |
|
Subcellular locationi
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 28 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 49 – 70 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 76 – 96 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 108 – 127 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 147 – 165 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 177 – 197 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 203 – 220 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 252 – 275 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 303 – 321 | HelicalUniRule annotationAdd BLAST | 19 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneUniRule annotation, MembraneFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_023982_0_1_9 |
OrthoDBi | 1151822at2 |
Family and domain databases
CDDi | cd06852, GT_MraY, 1 hit |
HAMAPi | MF_00038, MraY, 1 hit |
InterProi | View protein in InterPro IPR000715, Glycosyl_transferase_4 IPR003524, PNAcMuramoyl-5peptid_Trfase IPR018480, PNAcMuramoyl-5peptid_Trfase_CS |
PANTHERi | PTHR22926, PTHR22926, 1 hit |
Pfami | View protein in Pfam PF00953, Glycos_transf_4, 1 hit PF10555, MraY_sig1, 1 hit |
TIGRFAMsi | TIGR00445, mraY, 1 hit |
PROSITEi | View protein in PROSITE PS01347, MRAY_1, 1 hit PS01348, MRAY_2, 1 hit |
i Sequence
Sequence statusi: Complete.
R0BTE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIHETILAII IAFAISALLC PIIIPFLHKL KFGQQVRDDG PESHLKKQGT
60 70 80 90 100
PTMGGLIILS SIIITSVFYI PSYPKIIPVL FVTVGFGIIG FLDDYIKIVM
110 120 130 140 150
KRSEGLKPMQ KLVGQFIITG IFAWYLLNSG EVGTDMLIPF TGGFDGGSFL
160 170 180 190 200
SLGIFFVPAL FFIMLGTDNG VNFTDGLDGL CTSVTILVAT FLTIVAIGED
210 220 230 240 250
MGISPITGAV VGSLLGFLLF NVYPAKVFMG DTGSLALGGF VAASCYMMRM
260 270 280 290 300
PLFIPVIGLI YLVEVLSVII QVTYFKRTGG KRIFKMAPIH HHFELCGWSE
310 320
TRVVAVFAIV TAILCMVAYL GL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGYH01000003 Genomic DNA Translation: ENZ51908.1 |
RefSeqi | WP_002567061.1, NZ_KB851182.1 |
Genome annotation databases
EnsemblBacteriai | ENZ51908; ENZ51908; HMPREF1085_00623 |
GeneIDi | 23111723 |
PATRICi | fig|997894.4.peg.660 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AGYH01000003 Genomic DNA Translation: ENZ51908.1 |
RefSeqi | WP_002567061.1, NZ_KB851182.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5JNQ | X-ray | 2.60 | A | 1-322 | [»] | |
SMRi | R0BTE9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
EnsemblBacteriai | ENZ51908; ENZ51908; HMPREF1085_00623 |
GeneIDi | 23111723 |
PATRICi | fig|997894.4.peg.660 |
Phylogenomic databases
HOGENOMi | CLU_023982_0_1_9 |
OrthoDBi | 1151822at2 |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
Family and domain databases
CDDi | cd06852, GT_MraY, 1 hit |
HAMAPi | MF_00038, MraY, 1 hit |
InterProi | View protein in InterPro IPR000715, Glycosyl_transferase_4 IPR003524, PNAcMuramoyl-5peptid_Trfase IPR018480, PNAcMuramoyl-5peptid_Trfase_CS |
PANTHERi | PTHR22926, PTHR22926, 1 hit |
Pfami | View protein in Pfam PF00953, Glycos_transf_4, 1 hit PF10555, MraY_sig1, 1 hit |
TIGRFAMsi | TIGR00445, mraY, 1 hit |
PROSITEi | View protein in PROSITE PS01347, MRAY_1, 1 hit PS01348, MRAY_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R0BTE9_9FIRM | |
Accessioni | R0BTE9Primary (citable) accession number: R0BTE9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 26, 2013 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 37 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |