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UniProtKB - Q9ZW35 (PCNA2_ARATH)
Protein
Proliferating cell nuclear antigen 2
Gene
PCNA2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity).
May be involved in UV resistance.
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 61 – 80 | Sequence analysisAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA polymerase processivity factor activity Source: GO_Central
GO - Biological processi
- error-prone translesion synthesis Source: TAIR
- leading strand elongation Source: GO_Central
- mismatch repair Source: GO_Central
- regulation of DNA replication Source: InterPro
- translesion synthesis Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA replication |
Names & Taxonomyi
Protein namesi | Recommended name: Proliferating cell nuclear antigen 2Short name: PCNA 2 |
Gene namesi | Name:PCNA2 Ordered Locus Names:At2g29570 ORF Names:F16P2.5 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G29570 |
TAIRi | locus:2043062, AT2G29570 |
Subcellular locationi
Nucleus
Nucleus
- PCNA complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149178 | 1 – 264 | Proliferating cell nuclear antigen 2Add BLAST | 264 |
Proteomic databases
PaxDbi | Q9ZW35 |
PRIDEi | Q9ZW35 |
ProteomicsDBi | 236847 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9ZW35, baseline and differential |
Genevisiblei | Q9ZW35, AT |
Interactioni
Subunit structurei
Homo- and heterotrimer.
Interacts with POLH, ATXR5 and ATXR6.
3 PublicationsBinary interactionsi
Q9ZW35
With | #Exp. | IntAct |
---|---|---|
POLH [Q8H2D5] | 2 | EBI-1810473,EBI-1810451 |
Protein-protein interaction databases
BioGRIDi | 2856, 36 interactors |
IntActi | Q9ZW35, 3 interactors |
STRINGi | 3702.AT2G29570.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9ZW35 |
SMRi | Q9ZW35 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9ZW35 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PCNA family.Curated
Phylogenomic databases
eggNOGi | KOG1636, Eukaryota |
HOGENOMi | CLU_043978_3_0_1 |
InParanoidi | Q9ZW35 |
OMAi | TIRKDPN |
OrthoDBi | 1012066at2759 |
PhylomeDBi | Q9ZW35 |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID50110 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
TIGRFAMsi | TIGR00590, pcna, 1 hit |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit PS00293, PCNA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9ZW35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLELRLVQGS LLKKVLEAVK DLVNDANFDC STTGFSLQAM DSSHVALVSL
60 70 80 90 100
LLRSEGFEHY RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGSDTVT
110 120 130 140 150
FMFESPTQDK IADFEMKLMD IDSEHLGIPD AEYHSIVRMP SGEFSRICKD
160 170 180 190 200
LSSIGDTVVI SVTKEGVKFS TAGDIGTANI VLRQNTTVDK PEDAIVIEMN
210 220 230 240 250
EPVSLSFALR YMNSFTKATP LSETVTISLS SELPVVVEYK VAEMGYIRYY
260
LAPKIEEEED TKPE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU072918 mRNA Translation: ABU25234.1 AC004561 Genomic DNA Translation: AAC95182.1 CP002685 Genomic DNA Translation: AEC08274.1 BT029466 mRNA Translation: ABK59695.1 |
PIRi | H84697 |
RefSeqi | NP_180517.1, NM_128510.3 |
Genome annotation databases
EnsemblPlantsi | AT2G29570.1; AT2G29570.1; AT2G29570 |
GeneIDi | 817506 |
Gramenei | AT2G29570.1; AT2G29570.1; AT2G29570 |
KEGGi | ath:AT2G29570 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU072918 mRNA Translation: ABU25234.1 AC004561 Genomic DNA Translation: AAC95182.1 CP002685 Genomic DNA Translation: AEC08274.1 BT029466 mRNA Translation: ABK59695.1 |
PIRi | H84697 |
RefSeqi | NP_180517.1, NM_128510.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ZVW | X-ray | 2.50 | A/B/C/D/E/F/G/H | 1-255 | [»] | |
AlphaFoldDBi | Q9ZW35 | |||||
SMRi | Q9ZW35 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 2856, 36 interactors |
IntActi | Q9ZW35, 3 interactors |
STRINGi | 3702.AT2G29570.1 |
Proteomic databases
PaxDbi | Q9ZW35 |
PRIDEi | Q9ZW35 |
ProteomicsDBi | 236847 |
Genome annotation databases
EnsemblPlantsi | AT2G29570.1; AT2G29570.1; AT2G29570 |
GeneIDi | 817506 |
Gramenei | AT2G29570.1; AT2G29570.1; AT2G29570 |
KEGGi | ath:AT2G29570 |
Organism-specific databases
Araporti | AT2G29570 |
TAIRi | locus:2043062, AT2G29570 |
Phylogenomic databases
eggNOGi | KOG1636, Eukaryota |
HOGENOMi | CLU_043978_3_0_1 |
InParanoidi | Q9ZW35 |
OMAi | TIRKDPN |
OrthoDBi | 1012066at2759 |
PhylomeDBi | Q9ZW35 |
Miscellaneous databases
EvolutionaryTracei | Q9ZW35 |
PROi | PR:Q9ZW35 |
Gene expression databases
ExpressionAtlasi | Q9ZW35, baseline and differential |
Genevisiblei | Q9ZW35, AT |
Family and domain databases
HAMAPi | MF_00317, DNApol_clamp_arch, 1 hit |
IDEALi | IID50110 |
InterProi | View protein in InterPro IPR000730, Pr_cel_nuc_antig IPR022649, Pr_cel_nuc_antig_C IPR022659, Pr_cel_nuc_antig_CS IPR022648, Pr_cel_nuc_antig_N |
Pfami | View protein in Pfam PF02747, PCNA_C, 1 hit PF00705, PCNA_N, 1 hit |
PRINTSi | PR00339, PCNACYCLIN |
TIGRFAMsi | TIGR00590, pcna, 1 hit |
PROSITEi | View protein in PROSITE PS01251, PCNA_1, 1 hit PS00293, PCNA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCNA2_ARATH | |
Accessioni | Q9ZW35Primary (citable) accession number: Q9ZW35 Secondary accession number(s): A0JQ96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families