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UniProtKB - Q9ZW35 (PCNA2_ARATH)

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Protein

Proliferating cell nuclear antigen 2

Gene

PCNA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity). May be involved in UV resistance.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-ATH-110312 Translesion synthesis by REV1
R-ATH-110314 Recognition of DNA damage by PCNA-containing replication complex
R-ATH-110320 Translesion Synthesis by POLH
R-ATH-174411 Polymerase switching on the C-strand of the telomere
R-ATH-174414 Processive synthesis on the C-strand of the telomere
R-ATH-174417 Telomere C-strand (Lagging Strand) Synthesis
R-ATH-174437 Removal of the Flap Intermediate from the C-strand
R-ATH-4615885 SUMOylation of DNA replication proteins
R-ATH-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-ATH-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-ATH-5655862 Translesion synthesis by POLK
R-ATH-5656121 Translesion synthesis by POLI
R-ATH-5656169 Termination of translesion DNA synthesis
R-ATH-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-ATH-5696400 Dual Incision in GG-NER
R-ATH-6782135 Dual incision in TC-NER
R-ATH-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-ATH-69091 Polymerase switching
R-ATH-69166 Removal of the Flap Intermediate
R-ATH-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigen 2
Short name:
PCNA 2
Gene namesi
Name:PCNA2
Ordered Locus Names:At2g29570
ORF Names:F16P2.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G29570
TAIRilocus:2043062 AT2G29570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491781 – 264Proliferating cell nuclear antigen 2Add BLAST264

Proteomic databases

PaxDbiQ9ZW35
PRIDEiQ9ZW35

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZW35 baseline and differential
GenevisibleiQ9ZW35 AT

Interactioni

Subunit structurei

Homo- and heterotrimer. Interacts with POLH, ATXR5 and ATXR6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLHQ8H2D52EBI-1810473,EBI-1810451

Protein-protein interaction databases

BioGridi2856, 8 interactors
IntActiQ9ZW35, 3 interactors
STRINGi3702.AT2G29570.1

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi9 – 22Combined sources14
Beta strandi24 – 30Combined sources7
Beta strandi32 – 40Combined sources9
Beta strandi44 – 53Combined sources10
Helixi54 – 56Combined sources3
Beta strandi57 – 62Combined sources6
Beta strandi66 – 71Combined sources6
Helixi72 – 80Combined sources9
Beta strandi87 – 92Combined sources6
Beta strandi97 – 104Combined sources8
Beta strandi108 – 117Combined sources10
Beta strandi134 – 140Combined sources7
Helixi141 – 151Combined sources11
Turni152 – 154Combined sources3
Beta strandi156 – 163Combined sources8
Beta strandi166 – 173Combined sources8
Beta strandi176 – 182Combined sources7
Helixi191 – 193Combined sources3
Beta strandi196 – 201Combined sources6
Beta strandi203 – 208Combined sources6
Helixi209 – 215Combined sources7
Helixi216 – 221Combined sources6
Beta strandi223 – 229Combined sources7
Beta strandi235 – 241Combined sources7
Turni242 – 244Combined sources3
Beta strandi245 – 251Combined sources7

3D structure databases

ProteinModelPortaliQ9ZW35
SMRiQ9ZW35
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9ZW35

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
HOGENOMiHOG000211098
InParanoidiQ9ZW35
KOiK04802
OMAiMDNSHIS
OrthoDBiEOG09360IU7
PhylomeDBiQ9ZW35

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZW35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELRLVQGS LLKKVLEAVK DLVNDANFDC STTGFSLQAM DSSHVALVSL 
        60         70         80         90        100
LLRSEGFEHY RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGSDTVT 
       110        120        130        140        150
FMFESPTQDK IADFEMKLMD IDSEHLGIPD AEYHSIVRMP SGEFSRICKD 
       160        170        180        190        200
LSSIGDTVVI SVTKEGVKFS TAGDIGTANI VLRQNTTVDK PEDAIVIEMN 
       210        220        230        240        250
EPVSLSFALR YMNSFTKATP LSETVTISLS SELPVVVEYK VAEMGYIRYY 
       260 
LAPKIEEEED TKPE
Length:264
Mass (Da):29,222
Last modified:May 1, 1999 - v1
Checksum:i5A10FF87ABC86EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU072918 mRNA Translation: ABU25234.1
AC004561 Genomic DNA Translation: AAC95182.1
CP002685 Genomic DNA Translation: AEC08274.1
BT029466 mRNA Translation: ABK59695.1
PIRiH84697
RefSeqiNP_180517.1, NM_128510.3
UniGeneiAt.23904
At.64384

Genome annotation databases

EnsemblPlantsiAT2G29570.1; AT2G29570.1; AT2G29570
GeneIDi817506
GrameneiAT2G29570.1; AT2G29570.1; AT2G29570
KEGGiath:AT2G29570

Similar proteinsi

Entry informationi

Entry nameiPCNA2_ARATH
AccessioniPrimary (citable) accession number: Q9ZW35
Secondary accession number(s): A0JQ96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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