UniProtKB - Q9ZVI9 (PECT1_ARATH)
Protein
Ethanolamine-phosphate cytidylyltransferase
Gene
PECT1
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine. Essential for early embryonic development.1 Publication
Catalytic activityi
- EC:2.7.7.14
: phosphatidylethanolamine biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.Proteins known to be involved in the 3 steps of the subpathway in this organism are:
- Probable ethanolamine kinase (EMB1187)
- Ethanolamine-phosphate cytidylyltransferase (PECT1)
- Choline/ethanolaminephosphotransferase 2 (AAPT2), Choline/ethanolaminephosphotransferase 1 (AAPT1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 298 | CTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 262 – 263 | CTPBy similarity | 2 | |
Nucleotide bindingi | 270 – 273 | CTPBy similarity | 4 | |
Nucleotide bindingi | 346 – 349 | CTPBy similarity | 4 | |
Nucleotide bindingi | 377 – 381 | CTPBy similarity | 5 |
GO - Molecular functioni
- ethanolamine-phosphate cytidylyltransferase activity Source: TAIR
GO - Biological processi
- phosphatidylethanolamine biosynthetic process Source: TAIR
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | ARA:AT2G38670-MONOMER MetaCyc:AT2G38670-MONOMER |
UniPathwayi | UPA00558;UER00742 |
Names & Taxonomyi
Protein namesi | Recommended name: Ethanolamine-phosphate cytidylyltransferase (EC:2.7.7.14)Alternative name(s): CTP:phosphoethanolamine cytidylyltransferase Phosphorylethanolamine cytidylyltransferase 1 |
Gene namesi | Name:PECT1 Ordered Locus Names:At2g38670 ORF Names:T6A23.13 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G38670 |
TAIRi | locus:2064123, AT2G38670 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane 2 Publications; Single-pass membrane protein 2 Publications
Golgi apparatus
- Golgi apparatus Source: TAIR
Mitochondrion
- integral component of mitochondrial outer membrane Source: TAIR
- mitochondrion Source: TAIR
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePathology & Biotechi
Disruption phenotypei
Embryonic lethality when homozygous.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 126 | P → S in pect1-4; delayed embryo maturation and reduced fertility. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423341 | 1 – 421 | Ethanolamine-phosphate cytidylyltransferaseAdd BLAST | 421 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 416 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9ZVI9 |
PRIDEi | Q9ZVI9 |
ProteomicsDBi | 235114 |
PTM databases
iPTMneti | Q9ZVI9 |
SwissPalmi | Q9ZVI9 |
Expressioni
Tissue specificityi
Expressed in root tip, lateral root primordia, leaves, shoot apex, stem vascular bundles, pollen and embryos.1 Publication
Gene expression databases
ExpressionAtlasi | Q9ZVI9, baseline and differential |
Genevisiblei | Q9ZVI9, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 3791, 1 interactor |
STRINGi | 3702.AT2G38670.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytidylyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2803, Eukaryota |
HOGENOMi | CLU_031246_2_1_1 |
InParanoidi | Q9ZVI9 |
OMAi | DGNDCYR |
OrthoDBi | 871204at2759 |
PhylomeDBi | Q9ZVI9 |
Family and domain databases
CDDi | cd02174, CCT, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
InterProi | View protein in InterPro IPR041723, CCT IPR004821, Cyt_trans-like IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 2 hits |
TIGRFAMsi | TIGR00125, cyt_tran_rel, 2 hits |
i Sequence
Sequence statusi: Complete.
Q9ZVI9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVWEKEKIVG SCIVGGAAFA VGASFLHLFL KGELPLGLGL GLSCPWRILR
60 70 80 90 100
KRKPVRVYMD GCFDMMHYGH CNALRQARAL GDQLVVGVVS DEEIIANKGP
110 120 130 140 150
PVTPLHERMT MVKAVKWVDE VISDAPYAIT EDFMKKLFDE YQIDYIIHGD
160 170 180 190 200
DPCVLPDGTD AYALAKKAGR YKQIKRTEGV SSTDIVGRML LCVRERSISD
210 220 230 240 250
THSRSSLQRQ FSHGHSSPKF EDGASSAGTR VSHFLPTSRR IVQFSNGKGP
260 270 280 290 300
GPDARIIYID GAFDLFHAGH VEILRRAREL GDFLLVGIHN DQTVSAKRGA
310 320 330 340 350
HRPIMNLHER SLSVLACRYV DEVIIGAPWE VSRDTITTFD ISLVVHGTVA
360 370 380 390 400
ESDDFRKEED NPYSVPISMG IFQVLDSPLD ITTSTIIRRI VANHEAYQKR
410 420
NAKKEASEKK YYEQKSFVSG D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005499 Genomic DNA Translation: AAC67351.1 CP002685 Genomic DNA Translation: AEC09568.1 AY092984 mRNA Translation: AAM12983.1 AY128807 mRNA Translation: AAM91207.1 |
PIRi | H84807 |
RefSeqi | NP_181401.1, NM_129424.5 |
Genome annotation databases
EnsemblPlantsi | AT2G38670.1; AT2G38670.1; AT2G38670 |
GeneIDi | 818449 |
Gramenei | AT2G38670.1; AT2G38670.1; AT2G38670 |
KEGGi | ath:AT2G38670 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005499 Genomic DNA Translation: AAC67351.1 CP002685 Genomic DNA Translation: AEC09568.1 AY092984 mRNA Translation: AAM12983.1 AY128807 mRNA Translation: AAM91207.1 |
PIRi | H84807 |
RefSeqi | NP_181401.1, NM_129424.5 |
3D structure databases
SMRi | Q9ZVI9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 3791, 1 interactor |
STRINGi | 3702.AT2G38670.1 |
PTM databases
iPTMneti | Q9ZVI9 |
SwissPalmi | Q9ZVI9 |
Proteomic databases
PaxDbi | Q9ZVI9 |
PRIDEi | Q9ZVI9 |
ProteomicsDBi | 235114 |
Genome annotation databases
EnsemblPlantsi | AT2G38670.1; AT2G38670.1; AT2G38670 |
GeneIDi | 818449 |
Gramenei | AT2G38670.1; AT2G38670.1; AT2G38670 |
KEGGi | ath:AT2G38670 |
Organism-specific databases
Araporti | AT2G38670 |
TAIRi | locus:2064123, AT2G38670 |
Phylogenomic databases
eggNOGi | KOG2803, Eukaryota |
HOGENOMi | CLU_031246_2_1_1 |
InParanoidi | Q9ZVI9 |
OMAi | DGNDCYR |
OrthoDBi | 871204at2759 |
PhylomeDBi | Q9ZVI9 |
Enzyme and pathway databases
UniPathwayi | UPA00558;UER00742 |
BioCyci | ARA:AT2G38670-MONOMER MetaCyc:AT2G38670-MONOMER |
Miscellaneous databases
PROi | PR:Q9ZVI9 |
Gene expression databases
ExpressionAtlasi | Q9ZVI9, baseline and differential |
Genevisiblei | Q9ZVI9, AT |
Family and domain databases
CDDi | cd02174, CCT, 1 hit |
Gene3Di | 3.40.50.620, 2 hits |
InterProi | View protein in InterPro IPR041723, CCT IPR004821, Cyt_trans-like IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF01467, CTP_transf_like, 2 hits |
TIGRFAMsi | TIGR00125, cyt_tran_rel, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PECT1_ARATH | |
Accessioni | Q9ZVI9Primary (citable) accession number: Q9ZVI9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 18, 2013 |
Last sequence update: | May 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families