UniProtKB - Q9ZSV1 (PARP1_MAIZE)
Protein
Poly [ADP-ribose] polymerase 1
Gene
PARP1
Organism
Zea mays (Maize)
Status
Functioni
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).By similarity
Catalytic activityi
- NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.By similarity EC:2.4.2.30
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 91 | PARP-type 1PROSITE-ProRule annotationAdd BLAST | 84 | |
Zinc fingeri | 104 – 184 | PARP-type 2PROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- NAD+ ADP-ribosyltransferase activity Source: GO_Central
- NAD binding Source: InterPro
- protein ADP-ribosylase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- double-strand break repair Source: GO_Central
- protein poly-ADP-ribosylation Source: GO_Central
- response to abscisic acid Source: EnsemblPlants
- response to oxidative stress Source: EnsemblPlants
Keywordsi
Molecular function | DNA-binding, Glycosyltransferase, Transferase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PARP1 |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 403204 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000260500 | 1 – 980 | Poly [ADP-ribose] polymerase 1Add BLAST | 980 |
Keywords - PTMi
ADP-ribosylationProteomic databases
PaxDbi | Q9ZSV1 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9ZSV1, baseline and differential |
Genevisiblei | Q9ZSV1, ZM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 257 – 291 | SAPPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 385 – 476 | BRCTPROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 629 – 748 | PARP alpha-helicalPROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 755 – 980 | PARP catalyticPROSITE-ProRule annotationAdd BLAST | 226 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 8 – 91 | PARP-type 1PROSITE-ProRule annotationAdd BLAST | 84 | |
Zinc fingeri | 104 – 184 | PARP-type 2PROSITE-ProRule annotationAdd BLAST | 81 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1037, Eukaryota |
OrthoDBi | 909382at2759 |
Family and domain databases
Gene3Di | 1.20.142.10, 1 hit 2.20.140.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR012982, PADR1 IPR038650, PADR1_dom_sf IPR008288, PARP IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036930, WGR_dom_sf IPR008893, WGR_domain IPR001510, Znf_PARP IPR036957, Znf_PARP_sf |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF08063, PADR1, 1 hit PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF05406, WGR, 1 hit PF00645, zf-PARP, 2 hits |
PIRSFi | PIRSF000489, NAD_ADPRT, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM01335, PADR1, 1 hit SM00773, WGR, 1 hit SM01336, zf-PARP, 2 hits |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50064, PARP_ZN_FINGER_2, 2 hits PS50800, SAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9ZSV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPPKAWKA EYAKSGRASC KSCRSPIAKD QLRLGKMVQA SQFDGFMPMW
60 70 80 90 100
NHARCIFSKK NQIKSVDDVE GIDALRWDDQ EKIRNYVGSA SAGTSSTAAP
110 120 130 140 150
PEKCTIEIAP SARTSCRRCS EKITKGSVRL SAKLESEGPK GIPWYHANCF
160 170 180 190 200
FEVSPSATVE KFSGWDTLSD EDKRTMLDLV KKDVGNNEQN KGSKRKKSEN
210 220 230 240 250
DIDSYKSARL DESTSEGTVR NKGQLVDPRG SNTSSADIQL KLKEQSDTLW
260 270 280 290 300
KLKDGLKTHV SAAELRDMLE ANGQDTSGPE RHLLDRCADG MLFGALGPCP
310 320 330 340 350
VCANGMYYYN GQYQCSGNVS EWSKCTYSAT EPVRVKKKWQ IPHGTKNDYL
360 370 380 390 400
MKWFKSQKVK KPERVLPPMS PEKSGSKATQ RTSLLSSKGL DKLRFSVVGQ
410 420 430 440 450
SKEAANEWIE KLKLAGANFY ARVVKDIDCL IACGELDNEN AEVRKARRLK
460 470 480 490 500
IPIVREGYIG ECVKKNKMLP FDLYKLENAL ESSKGSTVTV KVKGRSAVHE
510 520 530 540 550
SSGLQDTAHI LEDGKSIYNA TLNMSDLALG VNSYYVLQII EQDDGSECYV
560 570 580 590 600
FRKWGRVGSE KIGGQKLEEM SKTEAIKEFK RLFLEKTGNS WEAWECKTNF
610 620 630 640 650
RKQPGRFYPL DVDYGVKKAP KRKDISEMKS SLAPQLLELM KMLFNVETYR
660 670 680 690 700
AAMMEFEINM SEMPLGKLSK ENIEKGFEAL TEIQNLLKDT ADQALAVRES
710 720 730 740 750
LIVAASNRFF TLIPSIHPHI IRDEDDLMIK AKMLEALQDI EIASKIVGFD
760 770 780 790 800
SDSDESLDDK YMKLHCDITP LAHDSEDYKL IEQYLLNTHA PTHKDWSLEL
810 820 830 840 850
EEVFSLDRDG ELNKYSRYKN NLHNKMLLWH GSRLTNFVGI LSQGLRIAPP
860 870 880 890 900
EAPVTGYMFG KGLYFADLVS KSAQYCYVDR NNPVGLMLLS EVALGDMYEL
910 920 930 940 950
KKATSMDKPP RGKHSTKGLG KTVPLESEFV KWRDDVVVPC GKPVPSSIRS
960 970 980
SELMYNEYIV YNTSQVKMQF LLKVRFHHKR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D6EKV8 | A0A1D6EKV8_MAIZE | Poly [ADP-ribose] polymerase | 103647201 ZEAMMB73_Zm00001d005168 | 690 | Annotation score: | ||
A0A1D6EKV6 | A0A1D6EKV6_MAIZE | Poly [ADP-ribose] polymerase | 103647201 ZEAMMB73_Zm00001d005168 | 513 | Annotation score: | ||
A0A1D6EKV9 | A0A1D6EKV9_MAIZE | Poly [ADP-ribose] polymerase | 103647201 ZEAMMB73_Zm00001d005168 | 290 | Annotation score: | ||
A0A1D6EKV5 | A0A1D6EKV5_MAIZE | Poly(ADP-ribose) polymerase2 | 103647201 ZEAMMB73_Zm00001d005168 | 614 | Annotation score: | ||
A0A1D6EKW0 | A0A1D6EKW0_MAIZE | Poly [ADP-ribose] polymerase | 103647201 ZEAMMB73_Zm00001d005168 | 248 | Annotation score: | ||
A0A1D6EKV7 | A0A1D6EKV7_MAIZE | Poly(ADP-ribose) polymerase2 | 103647201 ZEAMMB73_Zm00001d005168 | 377 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 – 64 | Missing in CAA10889 (PubMed:9778846).CuratedAdd BLAST | 11 | |
Sequence conflicti | 292 | L → I in CAA10889 (PubMed:9778846).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222589 mRNA Translation: CAA10889.1 AF093627 mRNA Translation: AAC79704.1 |
PIRi | T03657 |
RefSeqi | NP_001288538.1, NM_001301609.1 |
Genome annotation databases
EnsemblPlantsi | Zm00001d005168_T003; Zm00001d005168_P003; Zm00001d005168 |
GeneIDi | 103647201 |
Gramenei | Zm00001d005168_T003; Zm00001d005168_P003; Zm00001d005168 |
KEGGi | zma:103647201 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ222589 mRNA Translation: CAA10889.1 AF093627 mRNA Translation: AAC79704.1 |
PIRi | T03657 |
RefSeqi | NP_001288538.1, NM_001301609.1 |
3D structure databases
SMRi | Q9ZSV1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4577.GRMZM5G831712_P02 |
Proteomic databases
PaxDbi | Q9ZSV1 |
Genome annotation databases
EnsemblPlantsi | Zm00001d005168_T003; Zm00001d005168_P003; Zm00001d005168 |
GeneIDi | 103647201 |
Gramenei | Zm00001d005168_T003; Zm00001d005168_P003; Zm00001d005168 |
KEGGi | zma:103647201 |
Organism-specific databases
MaizeGDBi | 403204 |
Phylogenomic databases
eggNOGi | KOG1037, Eukaryota |
OrthoDBi | 909382at2759 |
Gene expression databases
ExpressionAtlasi | Q9ZSV1, baseline and differential |
Genevisiblei | Q9ZSV1, ZM |
Family and domain databases
Gene3Di | 1.20.142.10, 1 hit 2.20.140.10, 1 hit 2.20.25.630, 1 hit 3.30.1740.10, 2 hits 3.40.50.10190, 1 hit |
InterProi | View protein in InterPro IPR001357, BRCT_dom IPR036420, BRCT_dom_sf IPR012982, PADR1 IPR038650, PADR1_dom_sf IPR008288, PARP IPR012317, Poly(ADP-ribose)pol_cat_dom IPR004102, Poly(ADP-ribose)pol_reg_dom IPR036616, Poly(ADP-ribose)pol_reg_dom_sf IPR003034, SAP_dom IPR036930, WGR_dom_sf IPR008893, WGR_domain IPR001510, Znf_PARP IPR036957, Znf_PARP_sf |
Pfami | View protein in Pfam PF00533, BRCT, 1 hit PF08063, PADR1, 1 hit PF00644, PARP, 1 hit PF02877, PARP_reg, 1 hit PF05406, WGR, 1 hit PF00645, zf-PARP, 2 hits |
PIRSFi | PIRSF000489, NAD_ADPRT, 1 hit |
SMARTi | View protein in SMART SM00292, BRCT, 1 hit SM01335, PADR1, 1 hit SM00773, WGR, 1 hit SM01336, zf-PARP, 2 hits |
SUPFAMi | SSF142921, SSF142921, 1 hit SSF47587, SSF47587, 1 hit SSF52113, SSF52113, 1 hit |
PROSITEi | View protein in PROSITE PS50172, BRCT, 1 hit PS51060, PARP_ALPHA_HD, 1 hit PS51059, PARP_CATALYTIC, 1 hit PS50064, PARP_ZN_FINGER_2, 2 hits PS50800, SAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARP1_MAIZE | |
Accessioni | Q9ZSV1Primary (citable) accession number: Q9ZSV1 Secondary accession number(s): O24570 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |