Syntaxin-121

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein-membrane adaptor activity Source: TAIR <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane."
    Sutter J.U., Campanoni P., Tyrrell M., Blatt M.R.
    Plant Cell 18:935-954(2006) [PubMed] [Europe PMC] [Abstract]
• SNAP receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• SNARE binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• defense response Source: TAIR <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Potato homologs of Arabidopsis thaliana genes functional in defense signaling--identification, genetic mapping, and molecular cloning."
    Pajerowska K.M., Parker J.E., Gebhardt C.
    Mol Plant Microbe Interact 18:1107-1119(2005) [PubMed] [Europe PMC] [Abstract]
• defense response to fungus Source: TAIR <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "The PEN1 syntaxin defines a novel cellular compartment upon fungal attack and is required for the timely assembly of papillae."
    Assaad F.F., Qiu J.L., Youngs H., Ehrhardt D., Zimmerli L., Kalde M., Wanner G., Peck S.C., Edwards H., Ramonell K., Somerville C.R., Thordal-Christensen H.
    Mol Biol Cell 15:5118-5129(2004) [PubMed] [Europe PMC] [Abstract]
• exocytosis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intracellular protein transport Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• maintenance of protein location in plasma membrane Source: TAIR <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and K⁺ channel activity with vegetative growth."
    Eisenach C., Chen Z.H., Grefen C., Blatt M.R.
    Plant J 69:241-251(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of defense response Source: TAIRInferred from mutant phenotypeⁱ
  • "Conserved requirement for a plant host cell protein in powdery mildew pathogenesis."
    Consonni C., Humphry M.E., Hartmann H.A., Livaja M., Durner J., Westphal L., Vogel J., Lipka V., Kemmerling B., Schulze-Lefert P., Somerville S.C., Panstruga R.
    Nat. Genet. 38:716-720(2006) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane Source: TAIRInferred from mutant phenotypeⁱ
  • "The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and K⁺ channel activity with vegetative growth."
    Eisenach C., Chen Z.H., Grefen C., Blatt M.R.
    Plant J 69:241-251(2012) [PubMed] [Europe PMC] [Abstract]
• protein targeting to membrane Source: TAIRInferred from direct assayⁱ
  • "Selective targeting of plasma membrane and tonoplast traffic by inhibitory (dominant-negative) SNARE fragments."
    Tyrrell M., Campanoni P., Sutter J.U., Pratelli R., Paneque M., Sokolovski S., Blatt M.R.
    Plant J 51:1099-1115(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of stomatal movement Source: TAIRInferred from mutant phenotypeⁱ
  • "The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and K⁺ channel activity with vegetative growth."
    Eisenach C., Chen Z.H., Grefen C., Blatt M.R.
    Plant J 69:241-251(2012) [PubMed] [Europe PMC] [Abstract]
• response to abscisic acid Source: TAIR <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • Ref.1

    "A tobacco syntaxin with a role in hormonal control of guard cell ion channels."
    Leyman B., Geelen D., Quintero F.J., Blatt M.R.
    Science 283:537-540(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• response to fungus Source: TAIRInferred from mutant phenotypeⁱ
  • "The PEN1 syntaxin defines a novel cellular compartment upon fungal attack and is required for the timely assembly of papillae."
    Assaad F.F., Qiu J.L., Youngs H., Ehrhardt D., Zimmerli L., Kalde M., Wanner G., Peck S.C., Edwards H., Ramonell K., Somerville C.R., Thordal-Christensen H.
    Mol Biol Cell 15:5118-5129(2004) [PubMed] [Europe PMC] [Abstract]
• secretion by cell Source: TAIRInferred from direct assayⁱ
  • "Synergy among Exocyst and SNARE Interactions Identifies a Functional Hierarchy in Secretion during Vegetative Growth."
    Larson E.R., Ortmannova J., Donald N.A., Alvim J., Blatt M.R., Zarsky V.
    Plant Cell 32:2951-2963(2020) [PubMed] [Europe PMC] [Abstract]
• transpiration Source: TAIRInferred from mutant phenotypeⁱ
  • "The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and K⁺ channel activity with vegetative growth."
    Eisenach C., Chen Z.H., Grefen C., Blatt M.R.
    Plant J 69:241-251(2012) [PubMed] [Europe PMC] [Abstract]
• vesicle docking Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• vesicle fusion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• vesicle-mediated transport Source: TAIRInferred from mutant phenotypeⁱ
  • "Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability."
    Hachez C., Laloux T., Reinhardt H., Cavez D., Degand H., Grefen C., De Rycke R., Inze D., Blatt M.R., Russinova E., Chaumont F.
    Plant Cell 26:3132-3147(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• SNARE binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MNDLFSSSFS RFRSGEPSPR RDVAGGGDGV QMANPAGSTG GVNLDKFFED 
        60         70         80         90        100
VESVKEELKE LDRLNETLSS CHEQSKTLHN AKAVKDLRSK MDGDVGVALK 
       110        120        130        140        150
KAKMIKVKLE ALDRANAANR SLPGCGPGSS SDRTRTSVLN GLRKKLMDSM 
       160        170        180        190        200
DSFNRLRELI SSEYRETVQR RYFTVTGENP DERTLDRLIS TGESERFLQK 
       210        220        230        240        250
AIQEQGRGRV LDTINEIQER HDAVKDIEKN LRELHQVFLD MAVLVEHQGA 
       260        270        280        290        300
QLDDIESHVG RASSFIRGGT DQLQTARVYQ KNTRKWTCIA IIILIIIITV 
       310        320        330        340 
VVLAVLKPWN NSSGGGGGGG GGGTTGGSQP NSGTPPNPPQ ARRLLR     

        10         20         30         40         50
MANPAGSTGG VNLDKFFEDV ESVKEELKEL DRLNETLSSC HEQSKTLHNA 
        60         70         80         90        100
KAVKDLRSKM DGDVGVALKK AKMIKVKLEA LDRANAANRS LPGCGPGSSS 
       110        120        130        140        150
DRTRTSVLNG LRKKLMDSMD SFNRLRELIS SEYRETVQRR YFTVTGENPD 
       160        170        180        190        200
ERTLDRLIST GESERFLQKA IQEQGRGRVL DTINEIQERH DAVKDIEKNL 
       210        220        230        240        250
RELHQVFLDM AVLVEHQGAQ LDDIESHVGR ASSFIRGGTD QLQTARVYQK 
       260        270        280        290        300
NTRKWTCIAI IILIIIITVV VLAVLKPWNN SSGGGGGGGG GGTTGGSQPN 
       310 
SGTPPNPPQA RRLLR                                       

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Arabidopsis thaliana
   Arabidopsis thaliana: entries and gene names
2. SIMILARITY comments
   Index of protein domains and families