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Protein

L-lactate dehydrogenase

Gene

OJA1212_C06.25

Organism
Oryza sativa subsp. japonica (Rice)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Os06g0104900), L-lactate dehydrogenase (OsJ_19824), L-lactate dehydrogenase (OJA1212_C06.25), L-lactate dehydrogenase (Os02g0105400)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Active sitei212Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-OSA-70268 Pyruvate metabolism
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:OJA1212_C06.25Imported
Synonyms:Os02g0105400Imported
ORF Names:OJ1212_C06.24Imported, OJ1359_D06.5Imported, OsJ_05023Imported, OSNPB_020105400Imported
OrganismiOryza sativa subsp. japonica (Rice)Imported
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 2

Subcellular locationi

Expressioni

Gene expression databases

ExpressionAtlasiQ9ZRJ5 differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 179Ldh_1_NInterPro annotationAdd BLAST140
Domaini182 – 348Ldh_1_CInterPro annotationAdd BLAST167

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZRJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKASSLSEL GFDAEGASSG FFRPVADGGS TPTSHRRRLT KISVIGAGNV
60 70 80 90 100
GMAIAQTILT RDMADEIALV DAVPDKLRGE MLDLQHAAAF LPRVRLVSDT
110 120 130 140 150
DLAVTRGSDL AIVTAGARQI PGESRLNLLQ RNVALFRKIV PALAEHSPEA
160 170 180 190 200
LLLIVSNPVD VLTYVAWKLS GFPASRVIGS GTNLDSSRFR FLLAEHLQVN
210 220 230 240 250
AQDVQAYMVG EHGDSSVAIW SSMSVAGMPV LKSLRESHQS FDEEALEGIR
260 270 280 290 300
RAVVDSAYEV ISLKGYTSWA IGYSVASLAA SLLRDQHRIH PVSVLASGFH
310 320 330 340 350
GIPQDHEVFL SLPARLGRAG VLGVAEMELT EEEARRLRRS AKTLWENCQL

LDL
Length:353
Mass (Da):38,171
Last modified:May 1, 1999 - v1
Checksum:iFD670CDA2AF28D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13817 mRNA Translation: BAA02971.1
AP006720 Genomic DNA Translation: BAD06283.1
AP004049 Genomic DNA Translation: BAD07543.1
AP004851 Genomic DNA Translation: BAD28080.1
AP014958 Genomic DNA Translation: BAS76559.1
CM000139 Genomic DNA Translation: EAZ21418.1
PIRiT03785
UniGeneiOs.10215
Os.88367

Genome annotation databases

EnsemblPlantsiOs02t0105400-02; Os02t0105400-02; Os02g0105400
GrameneiOs02t0105400-02; Os02t0105400-02; Os02g0105400

Similar proteinsi

Entry informationi

Entry nameiQ9ZRJ5_ORYSJ
AccessioniPrimary (citable) accession number: Q9ZRJ5
Secondary accession number(s): Q43000
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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