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Entry version 140 (17 Jun 2020)
Sequence version 2 (27 Apr 2001)
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Protein

Homogentisate 1,2-dioxygenase

Gene

HGO

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe cation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. Homogentisate 1,2-dioxygenase (HGO)
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (AN1_LOCUS1311), Fumarylacetoacetase (At1g12050), Fumarylacetoacetase (FAH), Fumarylacetoacetase (C24_LOCUS1224)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi341IronBy similarity1
Metal bindingi347IronBy similarity1
Metal bindingi377IronBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
ARA:AT5G54080-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.13.11.5 399

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00139;UER00339

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HGO
Ordered Locus Names:At5g54080
ORF Names:MJP23.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G54080

The Arabidopsis Information Resource

More...
TAIRi
locus:2166567 AT5G54080

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002202441 – 461Homogentisate 1,2-dioxygenaseAdd BLAST461

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ZRA2

PRoteomics IDEntifications database

More...
PRIDEi
Q9ZRA2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
230235

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ZRA2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ZRA2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ZRA2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G54080.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ZRA2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1417 Eukaryota
COG3508 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027174_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZRA2

KEGG Orthology (KO)

More...
KOi
K00451

Identification of Orthologs from Complete Genome Data

More...
OMAi
FESIDQG

Database of Orthologous Groups

More...
OrthoDBi
795654at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ZRA2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005708 Homogentis_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11056 PTHR11056, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04209 HgmA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51182 SSF51182, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01015 hmgA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZRA2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEKKKELEE LKYQSGFGNH FSSEAIAGAL PLDQNSPLLC PYGLYAEQIS
60 70 80 90 100
GTSFTSPRKL NQRSWLYRVK PSVTHEPFKP RVPAHKKLVS EFDASNSRTN
110 120 130 140 150
PTQLRWRPED IPDSEIDFVD GLFTICGAGS SFLRHGFAIH MYVANTGMKD
160 170 180 190 200
SAFCNADGDF LLVPQTGRLW IETECGRLLV TPGEIAVIPQ GFRFSIDLPD
210 220 230 240 250
GKSRGYVAEI YGAHFQLPDL GPIGANGLAA SRDFLAPTAW FEDGLRPEYT
260 270 280 290 300
IVQKFGGELF TAKQDFSPFN VVAWHGNYVP YKYDLKKFCP YNTVLLDHGD
310 320 330 340 350
PSINTVLTAP TDKPGVALLD FVIFPPRWLV AEHTFRPPYY HRNCMSEFMG
360 370 380 390 400
LIYGAYEAKA DGFLPGGASL HSCMTPHGPD TTTYEATIAR VNAMAPSKLT
410 420 430 440 450
GTMAFMFESA LIPRVCHWAL ESPFLDHDYY QCWIGLKSHF SRISLDKTNV
460
ESTEKEPGAS E
Length:461
Mass (Da):51,455
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD90DD9638014D31
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7E → K in AAM65958 (Ref. 6) Curated1
Sequence conflicti69V → I in AAM65958 (Ref. 6) Curated1
Sequence conflicti116I → T in AAM65958 (Ref. 6) Curated1
Sequence conflicti146T → K in AAM65958 (Ref. 6) Curated1
Sequence conflicti181T → S in AAM65958 (Ref. 6) Curated1
Sequence conflicti231S → P in AAM65958 (Ref. 6) Curated1
Sequence conflicti428D → E in AAD00360 (Ref. 1) Curated1
Sequence conflicti452S → P in AAM65958 (Ref. 6) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U80668 mRNA Translation: AAD00360.1
AF130845 Genomic DNA Translation: AAF36499.1
AB018115 Genomic DNA Translation: BAA97130.1
CP002688 Genomic DNA Translation: AED96447.1
CP002688 Genomic DNA Translation: AED96448.1
AY140075 mRNA Translation: AAM98216.1
BT010329 mRNA Translation: AAQ55280.1
AY088421 mRNA Translation: AAM65958.1

NCBI Reference Sequences

More...
RefSeqi
NP_200219.1, NM_124787.4
NP_851187.1, NM_180856.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
835494

Gramene; a comparative resource for plants

More...
Gramenei
AT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G54080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80668 mRNA Translation: AAD00360.1
AF130845 Genomic DNA Translation: AAF36499.1
AB018115 Genomic DNA Translation: BAA97130.1
CP002688 Genomic DNA Translation: AED96447.1
CP002688 Genomic DNA Translation: AED96448.1
AY140075 mRNA Translation: AAM98216.1
BT010329 mRNA Translation: AAQ55280.1
AY088421 mRNA Translation: AAM65958.1
RefSeqiNP_200219.1, NM_124787.4
NP_851187.1, NM_180856.4

3D structure databases

SMRiQ9ZRA2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G54080.2

PTM databases

iPTMnetiQ9ZRA2

Proteomic databases

PaxDbiQ9ZRA2
PRIDEiQ9ZRA2
ProteomicsDBi230235

Genome annotation databases

EnsemblPlantsiAT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080
GeneIDi835494
GrameneiAT5G54080.1; AT5G54080.1; AT5G54080
AT5G54080.2; AT5G54080.2; AT5G54080
KEGGiath:AT5G54080

Organism-specific databases

AraportiAT5G54080
TAIRilocus:2166567 AT5G54080

Phylogenomic databases

eggNOGiKOG1417 Eukaryota
COG3508 LUCA
HOGENOMiCLU_027174_0_0_1
InParanoidiQ9ZRA2
KOiK00451
OMAiFESIDQG
OrthoDBi795654at2759
PhylomeDBiQ9ZRA2

Enzyme and pathway databases

UniPathwayiUPA00139;UER00339
BioCyciARA:AT5G54080-MONOMER
BRENDAi1.13.11.5 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ZRA2

Gene expression databases

ExpressionAtlasiQ9ZRA2 baseline and differential
GenevisibleiQ9ZRA2 AT

Family and domain databases

Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGD_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZRA2
Secondary accession number(s): Q8L9I0, Q9LDB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: June 17, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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