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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 May 1999)
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Protein

Exportin-2

Gene

CAS

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exportin-2
Short name:
Exp2
Alternative name(s):
Cellular apoptosis susceptibility protein homolog
Importin-alpha re-exporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAS
Ordered Locus Names:At2g46520
ORF Names:F11C10, F13A10.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G46520

The Arabidopsis Information Resource

More...
TAIRi
locus:2039109 AT2G46520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001172911 – 972Exportin-2Add BLAST972

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ZPY7

PRoteomics IDEntifications database

More...
PRIDEi
Q9ZPY7

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9ZPY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ZPY7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ZPY7 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds with high affinity to importin-alpha only in the presence of RanGTP.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4598, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT2G46520.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ZPY7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 104Importin N-terminalPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XPO2/CSE1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1992 Eukaryota
COG5657 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000201317

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZPY7

KEGG Orthology (KO)

More...
KOi
K18423

Identification of Orthologs from Complete Genome Data

More...
OMAi
MPYVFQM

Database of Orthologous Groups

More...
OrthoDBi
1248958at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ZPY7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
IPR005043 XPO2_C
IPR013713 XPO2_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00913 IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZPY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWNRETLVF LSQCFLNTLS PIPEPRRTAE RALSDAADQA NYGLAVLRLV
60 70 80 90 100
AEPAIDEQTR HAAAVNFKNH LRSRWHPAGD SGISPIVDSE KEQIKTLIVS
110 120 130 140 150
LMLSASPRIQ SQLSEALTVI GKHDFPKAWP ALLPELIANL QNAALAGDYV
160 170 180 190 200
SVNGILGTAS SIFKKFSYEY RTDALFVDLK YCLDNFAAPL TEIFLKTSSL
210 220 230 240 250
IDSAASSGGS PPILKPLFES QRLCCTIFYS LNFQDLPEFF EDHMKEWMGE
260 270 280 290 300
FKKYLSSNYP ALESTEEGLT LVDDLRAAIC ENINHYIEKN EEEFQGFLNE
310 320 330 340 350
FASVVWTLLR DVSKSPSRDQ LATTAIKFLT SVSTSVHHAL FAGDNVIKEI
360 370 380 390 400
CQSIVIPNVS LRVEDEEIFE MNYIEFIRRD MEGSDVDTRR RIACELLKGL
410 420 430 440 450
ATNYKTQVTE VVSLEIQRLL SSFSANPSAN WKDKDCAIYL VVSLSTKKAG
460 470 480 490 500
GASVSTDLID VQNFFANIIL PELQSRDVNS FPMLKAGSLK FLTMFRSHIP
510 520 530 540 550
KPFAMQLFPE LVRFLKAESN VVHSYAASCI EKLLLVKEEG ARGNRYAAGD
560 570 580 590 600
LSPFLLQLMT NLFDALKFPE SEENQYLMKC IMRVLGVADI SAEVAGPCIG
610 620 630 640 650
GLTSILSEVC KNPKNPIFNH YLFESVAVLV RRACERDISL ISAFETSLFP
660 670 680 690 700
SLQMILANDI TEFLPYGFQL LAQLVELNRP TLSPNYMQIF LLLLSPESWK
710 720 730 740 750
RSGNVPALVR LLQAFLQKAP HEVTQENRLS QVLGIFEKLV ASPSTDEQGF
760 770 780 790 800
YILNTIIENL DYSVIAPYMK GVWSALFTRV QNKKTVKFQK SLVIFMSLFL
810 820 830 840 850
VKHGQAYLVE TMNTVQPNII TAIVEHFWIP NLKLIMGSME VKLTAVAATR
860 870 880 890 900
LICETPALLD PSAAKLWGKM LDSIVTLVSR PEQERVLDEP EMPEISENVG
910 920 930 940 950
YTAAFVKLHN AGKKEEDPLK DIKDPKQFLV ASVSRLSSAS PGRYPQIIGE
960 970
NLEQANQTAL IQLCNAYNCG IA
Length:972
Mass (Da):108,657
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0D9C38E4E1EFBCE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD95016 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti787K → R in BAD95016 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ297282 mRNA Translation: CAC83300.1
AC006418 Genomic DNA Translation: AAD20163.1
AC006526 Genomic DNA Translation: AAM15266.1
CP002685 Genomic DNA Translation: AEC10713.1
AK222100 mRNA Translation: BAD95016.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
H84903

NCBI Reference Sequences

More...
RefSeqi
NP_182175.1, NM_130217.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G46520.1; AT2G46520.1; AT2G46520

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819263

Gramene; a comparative resource for plants

More...
Gramenei
AT2G46520.1; AT2G46520.1; AT2G46520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G46520

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297282 mRNA Translation: CAC83300.1
AC006418 Genomic DNA Translation: AAD20163.1
AC006526 Genomic DNA Translation: AAM15266.1
CP002685 Genomic DNA Translation: AEC10713.1
AK222100 mRNA Translation: BAD95016.1 Different initiation.
PIRiH84903
RefSeqiNP_182175.1, NM_130217.4

3D structure databases

SMRiQ9ZPY7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4598, 1 interactor
STRINGi3702.AT2G46520.1

PTM databases

SwissPalmiQ9ZPY7

Proteomic databases

PaxDbiQ9ZPY7
PRIDEiQ9ZPY7

Genome annotation databases

EnsemblPlantsiAT2G46520.1; AT2G46520.1; AT2G46520
GeneIDi819263
GrameneiAT2G46520.1; AT2G46520.1; AT2G46520
KEGGiath:AT2G46520

Organism-specific databases

AraportiAT2G46520
TAIRilocus:2039109 AT2G46520

Phylogenomic databases

eggNOGiKOG1992 Eukaryota
COG5657 LUCA
HOGENOMiHOG000201317
InParanoidiQ9ZPY7
KOiK18423
OMAiMPYVFQM
OrthoDBi1248958at2759
PhylomeDBiQ9ZPY7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ZPY7

Gene expression databases

ExpressionAtlasiQ9ZPY7 baseline and differential
GenevisibleiQ9ZPY7 AT

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
IPR005043 XPO2_C
IPR013713 XPO2_central
PfamiView protein in Pfam
PF03378 CAS_CSE1, 1 hit
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXPO2_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZPY7
Secondary accession number(s): Q56WE2, Q7GA14
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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