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Entry version 121 (12 Aug 2020)
Sequence version 1 (01 May 1999)
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Protein

Transmembrane 9 superfamily member 3

Gene

TMN3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 3Curated
Alternative name(s):
Endomembrane protein 91 Publication
Transmembrane nine protein 31 Publication
Short name:
AtTMN31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMN31 Publication
Synonyms:EMP91 Publication
Ordered Locus Names:At2g01970Imported
ORF Names:F14H20.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT2G01970

The Arabidopsis Information Resource

More...
TAIRi
locus:2041160, AT2G01970

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 229LumenalCuratedAdd BLAST210
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini251 – 302CytoplasmicCuratedAdd BLAST52
Transmembranei303 – 323Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini324 – 325LumenalCurated2
Transmembranei326 – 346Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini347 – 365CytoplasmicCuratedAdd BLAST19
Transmembranei366 – 386Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini387 – 397LumenalCuratedAdd BLAST11
Transmembranei398 – 418Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini419 – 452CytoplasmicCuratedAdd BLAST34
Transmembranei453 – 473Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini474 – 485LumenalCuratedAdd BLAST12
Transmembranei486 – 506Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini507 – 521CytoplasmicCuratedAdd BLAST15
Transmembranei522 – 542Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini543 – 553LumenalCuratedAdd BLAST11
Transmembranei554 – 574Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini575 – 592CytoplasmicCuratedAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043126020 – 592Transmembrane 9 superfamily member 3Sequence analysisAdd BLAST573

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ZPS7

PRoteomics IDEntifications database

More...
PRIDEi
Q9ZPS7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234451

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ZPS7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ZPS7, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131, 54 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ZPS7, 54 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G01970.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi581 – 586Endoplasmic reticulum export signalBy similarity6
Motifi590 – 592Golgi retention signalBy similarity3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal KXD/E motif functions as a Golgi retention signal, certainly through the binding to the COP1 coatomer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1277, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010714_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZPS7

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGSVSFW

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ZPS7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240, EMP70
IPR036259, MFS_trans_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10766, PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990, EMP70, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZPS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPTTLLLF IGALIFSGAG TVRSDASDHR YKDGDSVPLY ANKVGPFHNP
60 70 80 90 100
SETYRYFDLP FCIPEGVKDK KEALGEVLNG DRLVSAPYKL NFRDEKDSEV
110 120 130 140 150
YCKKKLSREE VEHFRRAVEK DYYFQMYYDD LPIWGFIGKV DKESKSDPSE
160 170 180 190 200
FKYFLYKHIQ FEILYNKDRV IEINARMDPH SLVDLTEDKE VDAEFMYTVK
210 220 230 240 250
WKETETSFEK RMDKYAMSSS LPHHLEIHWF SIINSCVTVL LLTGFLATIL
260 270 280 290 300
MRVLKNDFMK YAQDEEAADD QEETGWKYIH GDVFRFPKNK SLFAASLGSG
310 320 330 340 350
TQLFTLTIFI FMLSLVGVFY PYNRGALFTA LVVIYALTSG IAGYTASSFY
360 370 380 390 400
CQLEGKNWVR NLLLTGGLFC GPLFLTFCFL NTVAIAYSAT AALPFGTIIV
410 420 430 440 450
IVLIWTLVTS PLLVLGGIAG KNSKAEFQAP VRTTKYPREI PPLPWYRSAV
460 470 480 490 500
PQMAMAGFLP FSAIYIELYY IFASVWGHRI YTIYSILFIV FIILLIVTAF
510 520 530 540 550
ITVALTYFQL AAEDHEWWWR SFLCGGSTGL FIYAYCLYYY YARSDMSGFM
560 570 580 590
QTSFFFGYMA CICYGFFLML GTVGFRAALL FVRHIYRSIK CE
Length:592
Mass (Da):68,049
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i710C78B82A7A067C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006532 Genomic DNA Translation: AAD20090.1
CP002685 Genomic DNA Translation: AEC05528.1
AY058869 mRNA Translation: AAL24256.1
AK221852 mRNA Translation: BAD94118.1
AK226487 mRNA Translation: BAE98629.1
AK317573 mRNA Translation: BAH20237.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D84431

NCBI Reference Sequences

More...
RefSeqi
NP_178306.1, NM_126258.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G01970.1; AT2G01970.1; AT2G01970

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
814728

Gramene; a comparative resource for plants

More...
Gramenei
AT2G01970.1; AT2G01970.1; AT2G01970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G01970

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006532 Genomic DNA Translation: AAD20090.1
CP002685 Genomic DNA Translation: AEC05528.1
AY058869 mRNA Translation: AAL24256.1
AK221852 mRNA Translation: BAD94118.1
AK226487 mRNA Translation: BAE98629.1
AK317573 mRNA Translation: BAH20237.1
PIRiD84431
RefSeqiNP_178306.1, NM_126258.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131, 54 interactors
IntActiQ9ZPS7, 54 interactors
STRINGi3702.AT2G01970.1

Proteomic databases

PaxDbiQ9ZPS7
PRIDEiQ9ZPS7
ProteomicsDBi234451

Genome annotation databases

EnsemblPlantsiAT2G01970.1; AT2G01970.1; AT2G01970
GeneIDi814728
GrameneiAT2G01970.1; AT2G01970.1; AT2G01970
KEGGiath:AT2G01970

Organism-specific databases

AraportiAT2G01970
TAIRilocus:2041160, AT2G01970

Phylogenomic databases

eggNOGiKOG1277, Eukaryota
HOGENOMiCLU_010714_0_2_1
InParanoidiQ9ZPS7
OMAiLGSVSFW
OrthoDBi641127at2759
PhylomeDBiQ9ZPS7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ZPS7

Gene expression databases

ExpressionAtlasiQ9ZPS7, baseline and differential
GenevisibleiQ9ZPS7, AT

Family and domain databases

InterProiView protein in InterPro
IPR004240, EMP70
IPR036259, MFS_trans_sf
PANTHERiPTHR10766, PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990, EMP70, 1 hit
SUPFAMiSSF103473, SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMN3_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZPS7
Secondary accession number(s): B9DHM0, Q56X26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 26, 2014
Last sequence update: May 1, 1999
Last modified: August 12, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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