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Entry version 131 (10 Feb 2021)
Sequence version 1 (01 May 1999)
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Protein

Tubby-like F-box protein 1

Gene

TULP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubby-like F-box protein 1
Short name:
AtTLP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP1
Ordered Locus Names:At1g76900
ORF Names:F22K20.1, F7O12.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G76900

The Arabidopsis Information Resource

More...
TAIRi
locus:2025327, AT1G76900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002722291 – 455Tubby-like F-box protein 1Add BLAST455

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9ZP59

PRoteomics IDEntifications database

More...
PRIDEi
Q9ZP59

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
234618

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9ZP59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9ZP59, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9ZP59, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
29244, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q9ZP59, 3 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G76900.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ZP59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 112F-boxAdd BLAST59

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2502, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028236_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZP59

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCAMNSI

Database of Orthologous Groups

More...
OrthoDBi
1445357at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ZP59

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR018066, Tubby_C_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00646, F-box, 1 hit
PF01167, Tub, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01573, SUPERTUBBY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54518, SSF54518, 1 hit
SSF81383, SSF81383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01200, TUB_1, 1 hit
PS01201, TUB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZP59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFRSIVRDV RDSIGSLSRR SFDFKLSSLN KEGGKSRGSV QDSHEEQLVV
60 70 80 90 100
TIQETPWANL PPELLRDVIK RLEESESVWP ARRHVVACAS VCRSWRDMCK
110 120 130 140 150
EIVQSPELSG KITFPVSLKQ PGPRDATMQC FIKRDKSNLT YHLYLCLSPA
160 170 180 190 200
LLVENGKFLL SAKRIRRTTY TEYVISMHAD TISRSSNTYI GKIRSNFLGT
210 220 230 240 250
KFIIYDTQPA YNSNIARAVQ PVGLSRRFYS KRVSPKVPSG SYKIAQVSYE
260 270 280 290 300
LNVLGTRGPR RMHCAMNSIP ASSLAEGGTV PGQPDIIVPR SILDESFRSI
310 320 330 340 350
TSSSSRKITY DYSNDFSSAR FSDILGPLSE DQEVVLEEGK ERNSPPLVLK
360 370 380 390 400
NKPPRWHEQL QCWCLNFRGR VTVASVKNFQ LIAANQPQPQ PQPQPQPQPL
410 420 430 440 450
TQPQPSGQTD GPDKIILQFG KVGKDMFTMD FRYPLSAFQA FAICLSSFDT

KLACE
Length:455
Mass (Da):51,195
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53072DE655960C3E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF487267 mRNA Translation: AAQ06240.1
AC002291 Genomic DNA Translation: AAC00626.1
AC079283 Genomic DNA Translation: AAG51146.1
CP002684 Genomic DNA Translation: AEE35900.1
CP002684 Genomic DNA Translation: AEE35901.1
CP002684 Genomic DNA Translation: ANM61194.1
AY139758 mRNA Translation: AAM98079.1
BT003039 mRNA Translation: AAO23604.1

Protein sequence database of the Protein Information Resource

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PIRi
H96797

NCBI Reference Sequences

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RefSeqi
NP_001319391.1, NM_001334747.1
NP_177816.1, NM_106341.2
NP_849894.1, NM_179563.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G76900.1; AT1G76900.1; AT1G76900
AT1G76900.2; AT1G76900.2; AT1G76900
AT1G76900.3; AT1G76900.3; AT1G76900

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
844025

Gramene; a comparative resource for plants

More...
Gramenei
AT1G76900.1; AT1G76900.1; AT1G76900
AT1G76900.2; AT1G76900.2; AT1G76900
AT1G76900.3; AT1G76900.3; AT1G76900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G76900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF487267 mRNA Translation: AAQ06240.1
AC002291 Genomic DNA Translation: AAC00626.1
AC079283 Genomic DNA Translation: AAG51146.1
CP002684 Genomic DNA Translation: AEE35900.1
CP002684 Genomic DNA Translation: AEE35901.1
CP002684 Genomic DNA Translation: ANM61194.1
AY139758 mRNA Translation: AAM98079.1
BT003039 mRNA Translation: AAO23604.1
PIRiH96797
RefSeqiNP_001319391.1, NM_001334747.1
NP_177816.1, NM_106341.2
NP_849894.1, NM_179563.3

3D structure databases

SMRiQ9ZP59
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi29244, 5 interactors
IntActiQ9ZP59, 3 interactors
STRINGi3702.AT1G76900.2

PTM databases

iPTMnetiQ9ZP59

Proteomic databases

PaxDbiQ9ZP59
PRIDEiQ9ZP59
ProteomicsDBi234618

Genome annotation databases

EnsemblPlantsiAT1G76900.1; AT1G76900.1; AT1G76900
AT1G76900.2; AT1G76900.2; AT1G76900
AT1G76900.3; AT1G76900.3; AT1G76900
GeneIDi844025
GrameneiAT1G76900.1; AT1G76900.1; AT1G76900
AT1G76900.2; AT1G76900.2; AT1G76900
AT1G76900.3; AT1G76900.3; AT1G76900
KEGGiath:AT1G76900

Organism-specific databases

AraportiAT1G76900
TAIRilocus:2025327, AT1G76900

Phylogenomic databases

eggNOGiKOG2502, Eukaryota
HOGENOMiCLU_028236_3_0_1
InParanoidiQ9ZP59
OMAiHCAMNSI
OrthoDBi1445357at2759
PhylomeDBiQ9ZP59

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9ZP59

Gene expression databases

ExpressionAtlasiQ9ZP59, baseline and differential
GenevisibleiQ9ZP59, AT

Family and domain databases

InterProiView protein in InterPro
IPR036047, F-box-like_dom_sf
IPR001810, F-box_dom
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR018066, Tubby_C_CS
PfamiView protein in Pfam
PF00646, F-box, 1 hit
PF01167, Tub, 1 hit
PRINTSiPR01573, SUPERTUBBY
SUPFAMiSSF54518, SSF54518, 1 hit
SSF81383, SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS01200, TUB_1, 1 hit
PS01201, TUB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZP59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 1, 1999
Last modified: February 10, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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