Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calreticulin

Gene
N/A
Organism
Euglena gracilis
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107CarbohydrateBy similarity1
Binding sitei109CarbohydrateBy similarity1
Binding sitei125CarbohydrateBy similarity1
Binding sitei132CarbohydrateBy similarity1
Binding sitei314CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandCalcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
OrganismiEuglena gracilis
Taxonomic identifieri3039 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaEuglenidaEuglenalesEuglenaceaeEuglena

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000419019 – 401CalreticulinAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 134By similarity

Keywords - PTMi

Disulfide bond

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

ELMiQ9ZNY3

Structurei

3D structure databases

ProteinModelPortaliQ9ZNY3
SMRiQ9ZNY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati187 – 1981-1Add BLAST12
Repeati206 – 2171-2Add BLAST12
Repeati223 – 2341-3Add BLAST12
Repeati241 – 2521-4Add BLAST12
Repeati256 – 2662-1Add BLAST11
Repeati270 – 2802-2Add BLAST11
Repeati284 – 2942-3Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni187 – 2524 X approximate repeatsAdd BLAST66
Regioni256 – 2943 X approximate repeatsAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi398 – 401Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi348 – 397Asp/Glu/Lys-richAdd BLAST50

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).By similarity
The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
The zinc binding sites are localized to the N-domain.By similarity

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.10.250.10, 1 hit
InterProiView protein in InterPro
IPR001580 Calret/calnex
IPR018124 Calret/calnex_CS
IPR009169 Calreticulin
IPR009033 Calreticulin/calnexin_P_dom_sf
IPR013320 ConA-like_dom_sf
PANTHERiPTHR11073 PTHR11073, 1 hit
PfamiView protein in Pfam
PF00262 Calreticulin, 2 hits
PIRSFiPIRSF002356 Calreticulin, 1 hit
PRINTSiPR00626 CALRETICULIN
SUPFAMiSSF49899 SSF49899, 1 hit
SSF63887 SSF63887, 1 hit
PROSITEiView protein in PROSITE
PS00803 CALRETICULIN_1, 1 hit
PS00804 CALRETICULIN_2, 1 hit
PS00805 CALRETICULIN_REPEAT, 1 hit
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZNY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKELWLGLL LSSQAVLSTI YYKETFEPDW ETRWTHSTAK SDYGKFKLTS
60 70 80 90 100
GKFYGDKAKD AGIQTSQDAK FYAISSPIAS SFSNEGKDLV LQFSVKHEQD
110 120 130 140 150
IDCGGGYLKL LPSVDAAKFT GDTPYHIMFG PDICGATKKI HFILTYKGKN
160 170 180 190 200
LLWKKEPRCE TDTLSHTYTA VIKADRTYEV LVDQVKKESG TLEEDWEILK
210 220 230 240 250
PKTIPDPEDK KPADWVDEPD MVDPEDKKPE DWDKEPAQIP DPDATQPDDW
260 270 280 290 300
DEEEDGKWEA PMISNPKYKG EWKAKKIPNP AYKGVWKPRD IPNPEYEADD
310 320 330 340 350
KVHIFDEIAA VGFDLWQVKS GTIFDNIIVT DSLAEAKAFY DQTNGATKDA
360 370 380 390 400
EKKAFDSAEA DKRKKEEDER KKQEEEEKKT AEEDEDDDDE EEEEDDKKDE

L
Length:401
Mass (Da):45,911
Last modified:May 1, 1999 - v1
Checksum:i056B074C16292674
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09816 mRNA Translation: CAA70945.1

Similar proteinsi

Entry informationi

Entry nameiCALR_EUGGR
AccessioniPrimary (citable) accession number: Q9ZNY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health