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Entry version 118 (29 Sep 2021)
Sequence version 1 (01 May 1999)
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Protein

Bifunctional protein PutA

Gene

putA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oxidizes proline to glutamate for use as a carbon and nitrogen source.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 1 and 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei740UniRule annotation1
Active sitei774UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, OxidoreductaseUniRule annotationARBA annotation, RepressorUniRule annotation
Biological processProline metabolismUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00261;UER00373
UPA00261;UER00374

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional protein PutAUniRule annotation
Including the following 2 domains:
Proline dehydrogenaseUniRule annotation (EC:1.5.5.2UniRule annotation)
Alternative name(s):
Proline oxidaseUniRule annotation
Delta-1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:putAImported
Ordered Locus Names:jhp_0048Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000804 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
85963.jhp_0048

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 422Pro_dhInterPro annotationAdd BLAST295
Domaini522 – 964AldedhInterPro annotationAdd BLAST443

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation
In the C-terminal section; belongs to the aldehyde dehydrogenase family.UniRule annotation
In the N-terminal section; belongs to the proline dehydrogenase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0506, Bacteria
COG1012, Bacteria

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPWNFPV

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.309.10, 1 hit
3.40.605.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR025703, Bifunct_PutA
IPR029041, FAD-linked_oxidoreductase-like
IPR002872, Proline_DH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000197, Bifunct_PutA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZN12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKIIEDSLE LAKKLQDSIS NHLSEQEKAF HFKMQKLLNN PENKVMLIEL
60 70 80 90 100
MDRSFRCLDN KARFEMIEHV LDKYKSREIF SSFEKWLLMG FLSFGKMLPD
110 120 130 140 150
MSVPFFVNKI RSDTKAMVLD QEESQLRERI LKRKNEKIIL NVNFIGEEVL
160 170 180 190 200
GEEEASARFE KYSQALKSNY IQYISIKITT IFSQINILDF EYSKKEIVKR
210 220 230 240 250
LDALYALALE EEKKQGMPKF INLDMEEFRD LELTVESFME SIAKFDLNAG
260 270 280 290 300
IVLQAYIPDS YEYLKKLHAF SKERVLKGLK PIKIRFVKGA NMESEETIAS
310 320 330 340 350
MKDWALPTFS SKQDTDSNYN KMLDFVLEGD NYKYIHIGAA SHNIFEIAYV
360 370 380 390 400
YTRIHALNDP VVLEHFSFEM LEGMSLQASQ ELKEMHKLIL YAPVCDEAHF
410 420 430 440 450
NNAIAYLVRR LDENTSSDNF MKAFFNLKVG TSEWKDQEQR FLNSLKGIAT
460 470 480 490 500
LDNTTHRTQD RNAKQTGHTT YPNHSFKNES DTDFILKANR EWAKKVRDKM
510 520 530 540 550
HNAPILELYP EIDGRFEDPN LTPLEVFDRI HHKKIASVHL ADKEAILKAL
560 570 580 590 600
EVAKSDKSRF SQKSFTEIHA LLSQTAQLFR ERRGDLIGIS ALEVGKTFAE
610 620 630 640 650
TDAEVSEAID FLEFYPYSLR VLQEQNKKTK FTPKGVGVVI APWNFPVGIS
660 670 680 690 700
VGTIAAPLAA GNRVIYKPSS LSSVTGYKLC ECFWDAGVPR DALIYLPSKG
710 720 730 740 750
SDISEHLLKD ESIKFAILTG GEDTAYKMLK ANPTLALSAE TGGKNATIVS
760 770 780 790 800
KMADRDQAIK NVIHSAFSNS GQKCSATSLL VLEKEVYEDE NFKKTLIDAT
810 820 830 840 850
LSLSVGDPFD FKNKIGALAD KPNEKVIKAI DELKSYENYE IPASFVDDNP
860 870 880 890 900
YLMKPSIKYG TKKGDFTHQT ELFTPILSVM KAKDLDEAIE IVNSTGYGLT
910 920 930 940 950
SALESLDERE WEYYLERIEA GNIYINKPTT GAIVLRQPFG GVKKSAVGFG
960 970 980 990 1000
RKVGIFNYIT QFVNIHQEEE DENALKNPLS EALEGLTQKG YDEHTHELKR
1010 1020 1030 1040 1050
AIFMAKSYAY HYKHEFSQAK DYVKIRGEDN LFSYTKVTSV GYRITEKDTL
1060 1070 1080 1090 1100
SDMLGVALAC LISQIPLTIS IENERANKDL TFFLECLKAL QANAPIVYES
1110 1120 1130 1140 1150
LQKFSEKLNA FNRVRYLKSD LDLLHEQASR LGMVLATAKP CLNGRFELLY
1160 1170 1180
YHLERSVSIS YHRYGNLGSR VLRQPTCHKS CCAEK
Length:1,185
Mass (Da):135,226
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD681722CE4961DC6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD05632.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B71980

NCBI Reference Sequences

More...
RefSeqi
WP_001169408.1, NZ_CP011330.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD05632; AAD05632; jhp_0048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpj:jhp_0048

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|85963.30.peg.988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD05632.1
PIRiB71980
RefSeqiWP_001169408.1, NZ_CP011330.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi85963.jhp_0048

Genome annotation databases

EnsemblBacteriaiAAD05632; AAD05632; jhp_0048
KEGGihpj:jhp_0048
PATRICifig|85963.30.peg.988

Phylogenomic databases

eggNOGiCOG0506, Bacteria
COG1012, Bacteria
OMAiPPWNFPV

Enzyme and pathway databases

UniPathwayiUPA00261;UER00373
UPA00261;UER00374

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161, Ald_DH/histidinol_DH
IPR016163, Ald_DH_C
IPR016160, Ald_DH_CS_CYS
IPR029510, Ald_DH_CS_GLU
IPR016162, Ald_DH_N
IPR015590, Aldehyde_DH_dom
IPR025703, Bifunct_PutA
IPR029041, FAD-linked_oxidoreductase-like
IPR002872, Proline_DH_dom
PfamiView protein in Pfam
PF00171, Aldedh, 1 hit
PF01619, Pro_dh, 1 hit
PIRSFiPIRSF000197, Bifunct_PutA, 1 hit
SUPFAMiSSF51730, SSF51730, 1 hit
SSF53720, SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ZN12_HELPJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZN12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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