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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49Glyceraldehyde 3-phosphateBy similarity1
Active sitei82Proton donorBy similarity1
Metal bindingi83Zinc 1; catalyticBy similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi134Zinc 2By similarity1
Metal bindingi180Zinc 1; catalyticBy similarity1
Binding sitei181Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi210Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:jhp_0162
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787181 – 307Fructose-bisphosphate aldolaseAdd BLAST307

Proteomic databases

PRIDEiQ9ZMQ6

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi85963.jhp0162

Structurei

3D structure databases

ProteinModelPortaliQ9ZMQ6
SMRiQ9ZMQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni211 – 213Dihydroxyacetone phosphate bindingBy similarity3
Regioni253 – 256Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D2N Bacteria
COG0191 LUCA
KOiK01624
OMAiELCKDCI
OrthoDBiPOG091H00KZ

Family and domain databases

CDDicd00947 TBP_aldolase_IIB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR011289 Fruc_bis_ald_class-2
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01859 fruc_bis_ald_, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZMQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVKGNEILL KAHKEGYGVG AFNFVNFEML NAIFEAGNEE NSPLFIQASE
60 70 80 90 100
GAIKYMGIDM AVGMVKIMCE RYPHIPVALH LDHGTTFESC EKAVKAGFTS
110 120 130 140 150
VMIDASHHAF EENLELTSKV VKMAHNAGVS VEAELGRLMG IEDNISVDEK
160 170 180 190 200
DAVLVNPKEA ERFVKESQVD YLAPAIGTSH GAFKFKGEPK LDFERLQEVK
210 220 230 240 250
RLTNIPLVLH GASAIPDDVR KSYLDAGGDL KGSKGVPFEF LQESIKGGIN
260 270 280 290 300
KVNTDTDLRI AFIAEVRKVA NEDKSQFDLR KFFSPAQLAL KNVVKERMKL

LGSANKI
Length:307
Mass (Da):33,798
Last modified:May 1, 1999 - v1
Checksum:i183D55744097E248
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD05734.1
PIRiC71967
RefSeqiWP_000960453.1, NZ_CP011330.1

Genome annotation databases

EnsemblBacteriaiAAD05734; AAD05734; jhp_0162
KEGGihpj:jhp_0162
PATRICifig|85963.30.peg.860

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD05734.1
PIRiC71967
RefSeqiWP_000960453.1, NZ_CP011330.1

3D structure databases

ProteinModelPortaliQ9ZMQ6
SMRiQ9ZMQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp0162

Proteomic databases

PRIDEiQ9ZMQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD05734; AAD05734; jhp_0162
KEGGihpj:jhp_0162
PATRICifig|85963.30.peg.860

Phylogenomic databases

eggNOGiENOG4105D2N Bacteria
COG0191 LUCA
KOiK01624
OMAiELCKDCI
OrthoDBiPOG091H00KZ

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Family and domain databases

CDDicd00947 TBP_aldolase_IIB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR011289 Fruc_bis_ald_class-2
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01859 fruc_bis_ald_, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALF_HELPJ
AccessioniPrimary (citable) accession number: Q9ZMQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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