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UniProtKB - Q9ZML7 (CDSA_HELPJ)
Protein
Phosphatidate cytidylyltransferase
Gene
cdsA
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Functioni
Catalytic activityi
- EC:2.7.7.41
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- phosphatidate cytidylyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Nucleotidyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidate cytidylyltransferase (EC:2.7.7.41)Alternative name(s): CDP-DAG synthase CDP-DG synthase CDP-diacylglycerol synthase Short name: CDS CDP-diglyceride pyrophosphorylase CDP-diglyceride synthase CTP:phosphatidate cytidylyltransferase |
Gene namesi | Name:cdsA Ordered Locus Names:jhp_0201 |
Organismi | Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) |
Taxonomic identifieri | 85963 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 121 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090738 | 1 – 266 | Phosphatidate cytidylyltransferaseAdd BLAST | 266 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CDS family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0575, Bacteria |
OMAi | VFGDLYE |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9ZML7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKEELFKEKS RYITGVVLIV VAGLILYADN LLLFWAVLGG IYAVGFFEAL
60 70 80 90 100
RLFQVKASFS LYLILVLSWV AAYFNGHPVE CALISAMVMA SVIAYQKAHH
110 120 130 140 150
SEAILPFLYP GVGFFALFGV YKDFGAVAII WLLVVVVASD VGAFFGGKLL
160 170 180 190 200
GKTPFTATSP NKTLEGALIG VVLASVLGSF VGMGKLSGGF LMALLFSFLI
210 220 230 240 250
ALMAVFGDLY ESYLKRKVGV KDSGKILPGH GGVLDRLDSM LFGALSLHVL
260
LYFLEIWKET AVFLGD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001439 Genomic DNA Translation: AAD05785.1 |
PIRi | F71961 |
RefSeqi | WP_000656959.1, NZ_CP011330.1 |
Genome annotation databases
EnsemblBacteriai | AAD05785; AAD05785; jhp_0201 |
KEGGi | hpj:jhp_0201 |
PATRICi | fig|85963.30.peg.817 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001439 Genomic DNA Translation: AAD05785.1 |
PIRi | F71961 |
RefSeqi | WP_000656959.1, NZ_CP011330.1 |
3D structure databases
AlphaFoldDBi | Q9ZML7 |
SMRi | Q9ZML7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 85963.jhp_0201 |
Genome annotation databases
EnsemblBacteriai | AAD05785; AAD05785; jhp_0201 |
KEGGi | hpj:jhp_0201 |
PATRICi | fig|85963.30.peg.817 |
Phylogenomic databases
eggNOGi | COG0575, Bacteria |
OMAi | VFGDLYE |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00614 |
Family and domain databases
InterProi | View protein in InterPro IPR000374, PC_trans |
PROSITEi | View protein in PROSITE PS01315, CDS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDSA_HELPJ | |
Accessioni | Q9ZML7Primary (citable) accession number: Q9ZML7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families