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Protein

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Gene

folK

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (folK)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00155.

Names & Taxonomyi

Protein namesi
Recommended name:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
Gene namesi
Name:folK
Ordered Locus Names:jhp_0388
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682521 – 1632-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST163

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0388.

Structurei

3D structure databases

ProteinModelPortaliQ9ZM35.
SMRiQ9ZM35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HPPK family.Curated

Phylogenomic databases

eggNOGiENOG4105K8U. Bacteria.
COG0801. LUCA.
KOiK00950.
OMAiKDERWGP.
OrthoDBiPOG091H000M.

Family and domain databases

CDDicd00483. HPPK. 1 hit.
Gene3Di3.30.70.560. 1 hit.
InterProiView protein in InterPro
IPR000550. Hppk.
IPR035907. Hppk_sf.
PfamiView protein in Pfam
PF01288. HPPK. 1 hit.
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01498. folK. 1 hit.
PROSITEiView protein in PROSITE
PS00794. HPPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZM35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMREILTNRF FPSLFKKRLD FSNRVVLGLG SNLKNPLKIL KSCFLYFKNH
60 70 80 90 100
SKIGKIFSSP IYINPPFGYT NQPNFYNATI ILKTSLGLRH FFALVFYIER
110 120 130 140 150
RFGRARKRDF KDAPRTLDID IIAFNQVILR QNDLTLPHPK WSERDSVLVP
160
LTLQQILFKR EEW
Length:163
Mass (Da):19,341
Last modified:May 1, 1999 - v1
Checksum:iCAD6013BFC7D6936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA. Translation: AAD05959.1.
PIRiB71938.

Genome annotation databases

EnsemblBacteriaiAAD05959; AAD05959; jhp_0388.
KEGGihpj:jhp_0388.

Similar proteinsi

Entry informationi

Entry nameiHPPK_HELPJ
AccessioniPrimary (citable) accession number: Q9ZM35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome