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UniProtKB - Q9ZLV0 (Q9ZLV0_HELPJ)

Entry version 87 (31 Jul 2019)
Sequence version 1 (01 May 1999)
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Protein
Submitted name:

Cag island protein

Gene

14

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		HPYL85963:G1G1A-515-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cag island proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:14Imported
Synonyms:orf13Imported
Ordered Locus Names:jhp_0476Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000804 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 254HelicalSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		85963.jhp_0476

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 157DisorderedSequence analysisAdd BLAST157
Regioni169 – 219DisorderedSequence analysisAdd BLAST51
Regioni1496 – 1522DisorderedSequence analysisAdd BLAST27
Regioni1543 – 1571DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili350 – 370Sequence analysisAdd BLAST21
Coiled coili430 – 450Sequence analysisAdd BLAST21
Coiled coili506 – 526Sequence analysisAdd BLAST21
Coiled coili575 – 595Sequence analysisAdd BLAST21
Coiled coili752 – 772Sequence analysisAdd BLAST21
Coiled coili828 – 855Sequence analysisAdd BLAST28
Coiled coili904 – 931Sequence analysisAdd BLAST28
Coiled coili1011 – 1038Sequence analysisAdd BLAST28
Coiled coili1195 – 1222Sequence analysisAdd BLAST28
Coiled coili1335 – 1355Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 67PolyampholyteSequence analysisAdd BLAST41
Compositional biasi68 – 85PolarSequence analysisAdd BLAST18
Compositional biasi88 – 114PolyampholyteSequence analysisAdd BLAST27
Compositional biasi115 – 136AcidicSequence analysisAdd BLAST22
Compositional biasi1543 – 1568PolyampholyteSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CMA Bacteria
COG2948 LUCA

KEGG Orthology (KO)

More...KOi		K12092

Identification of Orthologs from Complete Genome Data

More...OMAi		YKDCVSR

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.128.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14585 CagY_I, 3 hits
PF07337 CagY_M, 27 hits
PF03743 TrbI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZLV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEENDKLET SKKAQQDSPQ DLSNEEATEA NHFEDLLKES TESSDNHLDN 
        60         70         80         90        100
PTETKTHFDE DKLEETQTQM DSGGNETSES SNGSLADKLF KKARKLVDDK 
       110        120        130        140        150
RPFTQQKSLD EETQKLNEED DQENNEHQEE TQTDLIDDET SEKTQQDSPQ 
       160        170        180        190        200
DLSNEEATEA NHFEDLLKES TESSDNHLDN PTESSDNHLD NPTETKTQET 
       210        220        230        240        250
KTHFDEDKPE EITDDSNDQE IIKGSKKKYI IGGIVVAVLI VIILFSRSIF 
       260        270        280        290        300
HYFVPLEDKS SRFSKDRNLY VNDEIQIRQE YNRLLKERNE KGNMIDKNLF 
       310        320        330        340        350
FNDDPNRTLY NYLNIAEIED KNPLRAFYEC ISNGGNYEEC LKLIKDKKLQ 
       360        370        380        390        400
DQMKKTLEAY NDCIKNAKTE EERIKCLDLI KDENLKKSLL NQQKVQVALD 
       410        420        430        440        450
CLKNAKTDEE RKECLKLIND PEIREKFRKE LELQKELQEY KDCIKNAKTE 
       460        470        480        490        500
AEKNECLKGL SKEAIERLKQ QALDCLKNAK TDEERKECLK NIPQDLQKEL 
       510        520        530        540        550
LADMSVKAYK DCVSRARNEK EKQECEKLLT PEAKKLLENQ ALDCLKNAKT 
       560        570        580        590        600
DEERKECLKN LPKDLQSDIL AKESLKAYKD CASQAKTEAE KKECEKLLTP 
       610        620        630        640        650
EAKKLLEEEA KESVKAYLDC VSQAKTEAEK KECEKLLTPE AKKKLEEAKK 
       660        670        680        690        700
SVRAYLDCVS KAKNEAERKE CEKLLTPEAK KLLENQALDC LKNAKTDEER 
       710        720        730        740        750
KECLKDLPKD LQKKVLAKES VRVYLDCVSK AKNEAERKEC EKLLTPEARK 
       760        770        780        790        800
LLEEAKKSVK AYKDCVLRAR NEKEKQECEK LLTPEARKLL EESKKSVKAY 
       810        820        830        840        850
LDCVSKAKNE AERKECEKLL TPEARKLLEE AKESVKAYKD CVSRARNEKE 
       860        870        880        890        900
KQECEKLLTP EARKLLEESK KSVKAYLDCV SKAKNEAERK ECEKLLTPEA 
       910        920        930        940        950
RKLLEEAKES VKAYKDCVSR ARNEKEKQEC EKLLTPEAKK LLENQALDCL 
       960        970        980        990       1000
KNAKTEAEKK RCVKDLPKDL QKKVLAKESV RVYLDCVSKA KNEAERKECE 
      1010       1020       1030       1040       1050
KLLTPEARKL LEEAKESVKA YKDCVSRARN EKEKQECEKL LTPEARKLLE 
      1060       1070       1080       1090       1100
QEVKKSVKAY LDCVSRARNE KEKQECEKLL TPEARKLLEN QALDCLKNAK 
      1110       1120       1130       1140       1150
TEAEKKRCVK DLPKDLQKKV LAKESVKAYL DCVSRARNEK EKKECEKLLT 
      1160       1170       1180       1190       1200
PEARKLLEES KKSVKAYLDC VSKAKNEAEK KECEKLLTPE ARKLLEEAKE 
      1210       1220       1230       1240       1250
SVKAYKDCVS RARNEKEKQE CEKLLTPEAR KLLEQEVKKS VKAYLDCVSR 
      1260       1270       1280       1290       1300
ARNEKEKQEC EKLLTPEARK FLEKQRQQKD KAIKDCLKNA DPNDRAAIMK 
      1310       1320       1330       1340       1350
CLDGLSDEEK LKYLQEAREK AVLDCLKTAR TDEEKRKCQN LYSDLIQEIQ 
      1360       1370       1380       1390       1400
NKKAQNKQNQ LSKTERLHQA SECLDNLDDP TDQEAIEQCL EGLSDSERAL 
      1410       1420       1430       1440       1450
ILGIKRQADE VDRIYSDLRS RKTFDNMAAK GYPLLPMDFK NGGDIATINA 
      1460       1470       1480       1490       1500
TNVDADKIAS DNPIYASIEP DITKQYETEK TIKDKSLEAK LAKALGGDKK 
      1510       1520       1530       1540       1550
DDDKEKGKKP TAETKAESNK IDKDVAETAK NISEIALKNK KEKSGDFVDE 
      1560       1570       1580       1590       1600
NGNPIDDKKK EEKQDETSPV KQAFIGKSDP TFVLAQYTPI EITLTSKVDA 
      1610       1620       1630       1640       1650
TLTGIVSGVV AKDVWNMNGT MILLDKGTKV YGNYQSVKGG TPIMTRLMIV 
      1660       1670       1680       1690       1700
FTKAITPDGV IIPLANAQAA GMLGEAGVDG YVNNHFMKRI GFAVIASVVN 
      1710       1720       1730       1740       1750
SFLQTAPIIA LDKLIGLGKG RSERTPEFNY ALGQAINGSM QSSAQMSNQI 
      1760       1770       1780       1790       1800
LGQLMNIPPS FYKNEGDSIK ILTMDDIDFS GVYDVKITNK SVVDEIIKQS 
      1810 
TKTLSREHEE ITTSPKGGN
Length:1,819
Mass (Da):207,507
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE76762B5A7FA371D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06047.1

Protein sequence database of the Protein Information Resource

More...PIRi		A71928

NCBI Reference Sequences

More...RefSeqi		WP_001001431.1, NC_000921.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAD06047; AAD06047; jhp_0476

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hpj:jhp_0476

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06047.1
PIRiA71928
RefSeqiWP_001001431.1, NC_000921.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi85963.jhp_0476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06047; AAD06047; jhp_0476
KEGGihpj:jhp_0476

Phylogenomic databases

eggNOGiENOG4105CMA Bacteria
COG2948 LUCA
KOiK12092
OMAiYKDCVSR

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-515-MONOMER

Family and domain databases

Gene3Di2.40.128.260, 1 hit
InterProiView protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI
PfamiView protein in Pfam
PF14585 CagY_I, 3 hits
PF07337 CagY_M, 27 hits
PF03743 TrbI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ZLV0_HELPJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZLV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 31, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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