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Entry version 87 (31 Jul 2019)
Sequence version 1 (01 May 1999)
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Protein
Submitted name:

Cag island protein

Gene

14

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
HPYL85963:G1G1A-515-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cag island proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:14Imported
Synonyms:orf13Imported
Ordered Locus Names:jhp_0476Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000804 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei229 – 254HelicalSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
85963.jhp_0476

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 157DisorderedSequence analysisAdd BLAST157
Regioni169 – 219DisorderedSequence analysisAdd BLAST51
Regioni1496 – 1522DisorderedSequence analysisAdd BLAST27
Regioni1543 – 1571DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili350 – 370Sequence analysisAdd BLAST21
Coiled coili430 – 450Sequence analysisAdd BLAST21
Coiled coili506 – 526Sequence analysisAdd BLAST21
Coiled coili575 – 595Sequence analysisAdd BLAST21
Coiled coili752 – 772Sequence analysisAdd BLAST21
Coiled coili828 – 855Sequence analysisAdd BLAST28
Coiled coili904 – 931Sequence analysisAdd BLAST28
Coiled coili1011 – 1038Sequence analysisAdd BLAST28
Coiled coili1195 – 1222Sequence analysisAdd BLAST28
Coiled coili1335 – 1355Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 67PolyampholyteSequence analysisAdd BLAST41
Compositional biasi68 – 85PolarSequence analysisAdd BLAST18
Compositional biasi88 – 114PolyampholyteSequence analysisAdd BLAST27
Compositional biasi115 – 136AcidicSequence analysisAdd BLAST22
Compositional biasi1543 – 1568PolyampholyteSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CMA Bacteria
COG2948 LUCA

KEGG Orthology (KO)

More...
KOi
K12092

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKDCVSR

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.128.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14585 CagY_I, 3 hits
PF07337 CagY_M, 27 hits
PF03743 TrbI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZLV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEENDKLET SKKAQQDSPQ DLSNEEATEA NHFEDLLKES TESSDNHLDN
60 70 80 90 100
PTETKTHFDE DKLEETQTQM DSGGNETSES SNGSLADKLF KKARKLVDDK
110 120 130 140 150
RPFTQQKSLD EETQKLNEED DQENNEHQEE TQTDLIDDET SEKTQQDSPQ
160 170 180 190 200
DLSNEEATEA NHFEDLLKES TESSDNHLDN PTESSDNHLD NPTETKTQET
210 220 230 240 250
KTHFDEDKPE EITDDSNDQE IIKGSKKKYI IGGIVVAVLI VIILFSRSIF
260 270 280 290 300
HYFVPLEDKS SRFSKDRNLY VNDEIQIRQE YNRLLKERNE KGNMIDKNLF
310 320 330 340 350
FNDDPNRTLY NYLNIAEIED KNPLRAFYEC ISNGGNYEEC LKLIKDKKLQ
360 370 380 390 400
DQMKKTLEAY NDCIKNAKTE EERIKCLDLI KDENLKKSLL NQQKVQVALD
410 420 430 440 450
CLKNAKTDEE RKECLKLIND PEIREKFRKE LELQKELQEY KDCIKNAKTE
460 470 480 490 500
AEKNECLKGL SKEAIERLKQ QALDCLKNAK TDEERKECLK NIPQDLQKEL
510 520 530 540 550
LADMSVKAYK DCVSRARNEK EKQECEKLLT PEAKKLLENQ ALDCLKNAKT
560 570 580 590 600
DEERKECLKN LPKDLQSDIL AKESLKAYKD CASQAKTEAE KKECEKLLTP
610 620 630 640 650
EAKKLLEEEA KESVKAYLDC VSQAKTEAEK KECEKLLTPE AKKKLEEAKK
660 670 680 690 700
SVRAYLDCVS KAKNEAERKE CEKLLTPEAK KLLENQALDC LKNAKTDEER
710 720 730 740 750
KECLKDLPKD LQKKVLAKES VRVYLDCVSK AKNEAERKEC EKLLTPEARK
760 770 780 790 800
LLEEAKKSVK AYKDCVLRAR NEKEKQECEK LLTPEARKLL EESKKSVKAY
810 820 830 840 850
LDCVSKAKNE AERKECEKLL TPEARKLLEE AKESVKAYKD CVSRARNEKE
860 870 880 890 900
KQECEKLLTP EARKLLEESK KSVKAYLDCV SKAKNEAERK ECEKLLTPEA
910 920 930 940 950
RKLLEEAKES VKAYKDCVSR ARNEKEKQEC EKLLTPEAKK LLENQALDCL
960 970 980 990 1000
KNAKTEAEKK RCVKDLPKDL QKKVLAKESV RVYLDCVSKA KNEAERKECE
1010 1020 1030 1040 1050
KLLTPEARKL LEEAKESVKA YKDCVSRARN EKEKQECEKL LTPEARKLLE
1060 1070 1080 1090 1100
QEVKKSVKAY LDCVSRARNE KEKQECEKLL TPEARKLLEN QALDCLKNAK
1110 1120 1130 1140 1150
TEAEKKRCVK DLPKDLQKKV LAKESVKAYL DCVSRARNEK EKKECEKLLT
1160 1170 1180 1190 1200
PEARKLLEES KKSVKAYLDC VSKAKNEAEK KECEKLLTPE ARKLLEEAKE
1210 1220 1230 1240 1250
SVKAYKDCVS RARNEKEKQE CEKLLTPEAR KLLEQEVKKS VKAYLDCVSR
1260 1270 1280 1290 1300
ARNEKEKQEC EKLLTPEARK FLEKQRQQKD KAIKDCLKNA DPNDRAAIMK
1310 1320 1330 1340 1350
CLDGLSDEEK LKYLQEAREK AVLDCLKTAR TDEEKRKCQN LYSDLIQEIQ
1360 1370 1380 1390 1400
NKKAQNKQNQ LSKTERLHQA SECLDNLDDP TDQEAIEQCL EGLSDSERAL
1410 1420 1430 1440 1450
ILGIKRQADE VDRIYSDLRS RKTFDNMAAK GYPLLPMDFK NGGDIATINA
1460 1470 1480 1490 1500
TNVDADKIAS DNPIYASIEP DITKQYETEK TIKDKSLEAK LAKALGGDKK
1510 1520 1530 1540 1550
DDDKEKGKKP TAETKAESNK IDKDVAETAK NISEIALKNK KEKSGDFVDE
1560 1570 1580 1590 1600
NGNPIDDKKK EEKQDETSPV KQAFIGKSDP TFVLAQYTPI EITLTSKVDA
1610 1620 1630 1640 1650
TLTGIVSGVV AKDVWNMNGT MILLDKGTKV YGNYQSVKGG TPIMTRLMIV
1660 1670 1680 1690 1700
FTKAITPDGV IIPLANAQAA GMLGEAGVDG YVNNHFMKRI GFAVIASVVN
1710 1720 1730 1740 1750
SFLQTAPIIA LDKLIGLGKG RSERTPEFNY ALGQAINGSM QSSAQMSNQI
1760 1770 1780 1790 1800
LGQLMNIPPS FYKNEGDSIK ILTMDDIDFS GVYDVKITNK SVVDEIIKQS
1810
TKTLSREHEE ITTSPKGGN
Length:1,819
Mass (Da):207,507
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE76762B5A7FA371D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06047.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A71928

NCBI Reference Sequences

More...
RefSeqi
WP_001001431.1, NC_000921.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD06047; AAD06047; jhp_0476

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hpj:jhp_0476

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06047.1
PIRiA71928
RefSeqiWP_001001431.1, NC_000921.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi85963.jhp_0476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06047; AAD06047; jhp_0476
KEGGihpj:jhp_0476

Phylogenomic databases

eggNOGiENOG4105CMA Bacteria
COG2948 LUCA
KOiK12092
OMAiYKDCVSR

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-515-MONOMER

Family and domain databases

Gene3Di2.40.128.260, 1 hit
InterProiView protein in InterPro
IPR029285 CagY_I
IPR010853 CagY_M
IPR005498 T4SS_VirB10/TraB/TrbI
IPR042217 T4SS_VirB10/TrbI
PfamiView protein in Pfam
PF14585 CagY_I, 3 hits
PF07337 CagY_M, 27 hits
PF03743 TrbI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ZLV0_HELPJ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZLV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 31, 2019
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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