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UniProtKB - Q9ZLT1 (CAGA_HELPJ)

Entry version 91 (02 Dec 2020)
Sequence version 1 (01 May 1999)
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Protein

Cytotoxicity-associated immunodominant antigen

Gene

cagA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be necessary for the transcription, folding, export, or function of the cytotoxin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		HPYL85963:G1G1A-537-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytotoxicity-associated immunodominant antigen
Alternative name(s):
120 kDa protein
CAG pathogenicity island protein 26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cagA
Synonyms:cag26, cai
Ordered Locus Names:jhp_0495
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri85963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000804 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892781 – 1167Cytotoxicity-associated immunodominant antigenAdd BLAST1167

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9ZLT1, 1 interactor

STRING: functional protein association networks

More...STRINGi		85963.jhp_0495

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9ZLT1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 249Poly-Thr4
Compositional biasi882 – 889Poly-Asn8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1842, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		PNYKFNQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005169, CagA
IPR004355, IVSec_CagA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03507, CagA, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01553, TYPE4SSCAGA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZLT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNEAINQQP QTEAAFNPQQ FINNLQVAFI KVDNVVASFD PNQKPIVDKN 
        60         70         80         90        100
DRDNRQAFEK ISQLREEFAN KAIKNPTKKN QYFSSFISKS NDLIDKDNLI 
       110        120        130        140        150
DTGSSIKSFQ KFGTQRYQIF MNWVSHQNDP SKINTQKIRG FMENIIQPPI 
       160        170        180        190        200
SDDKEKAEFL RSAKQAFAGI IIGNQIRSDQ KFMGVFDESL KERQEAEKNG 
       210        220        230        240        250
EPNGDPTGGD WLDIFLSFVF NKKQSSDLKE TLNQEPVPHV QPDVATTTTD 
       260        270        280        290        300
IQSLPPEARD LLDERGNFSK FTLGDMNMLD VEGVADIDPN YKFNQLLIHN 
       310        320        330        340        350
NALSSVLMGS HNGIEPEKVS LLYGNNGGPE ARHDWNATVG YKNQRGDNVA 
       360        370        380        390        400
TLINVHMKNG SGLVIAGGEK GINNPSFYLY KEDQLTGSQR ALSQEEIQNK 
       410        420        430        440        450
VDFMEFLAQN NAKLDNLSKK EKEKFQNEIE DFQKDSKAYL DALGNDHIAF 
       460        470        480        490        500
VSKKDKKHLA LVAEFGNGEL SYTLKDYGKK ADKALDREAK TTLQGSLKHD 
       510        520        530        540        550
GVMFVDYSNF KYTNASKSPD KGVGATNGVS HLEAGFSKVA VFNLPNLNNL 
       560        570        580        590        600
AITSVVRQDL EDKLIAKGLS PQEANKLVKD FLSSNKELVG KALNFNKAVA 
       610        620        630        640        650
EAKNTGNYDE VKQAQKDLEK SLKKRERLEK DVAKNLESKS GNKNKMEAKS 
       660        670        680        690        700
QANSQKDEIF ALINKEANRD ARAIAYAQNL KGIKRELSDK LENINKDLKD 
       710        720        730        740        750
FSKSFDEFKN GKNKDFSKAE ETLKALKGSV KDLGINPEWI SKVENLNAAL 
       760        770        780        790        800
NEFKNGKNKD FSKVTQAKSD LENSIKDVII NQKITDKVDN LNQAVSVAKA 
       810        820        830        840        850
TGDFSGVEQA LADLKNFSKE QLAQQAQKNE DFNTGKNSAL YQSVKNGVNG 
       860        870        880        890        900
TLVGNGLSKA EATTLSKNFS DIKKELNAKL GNFNNNNNNG LENSTEPIYT 
       910        920        930        940        950
QVAKKVKAKI DRLDQIASGL GDVGQAASFL LKRHDKVDDL SKVGLSANHE 
       960        970        980        990       1000
PIYATIDDLG GPFPLKRHDK VDDLSKVGLS REQKLTQKID NLNQAVSEAK 
      1010       1020       1030       1040       1050
ASHFDNLDQM IDKLKDSTKK NVVNLYVESA KKVPTSLSAK LDNYATNSHT 
      1060       1070       1080       1090       1100
RINSNVKNGT INEKATGMLT QKNSEWLKLV NDKIVAHNVG SAPLSAYDKI 
      1110       1120       1130       1140       1150
GFNQKNMKDY SDSFKFSTRL SNAVKDIKSG FVQFLTNIFS MGSYSLMKAS 
      1160 
VEHGVKNTNT KGGFQKS
Length:1,167
Mass (Da):129,730
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD5E86B81CEBD0F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06073.1

Protein sequence database of the Protein Information Resource

More...PIRi		B71924

NCBI Reference Sequences

More...RefSeqi		WP_000180410.1, NC_000921.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAD06073; AAD06073; jhp_0495

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hpj:jhp_0495

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06073.1
PIRiB71924
RefSeqiWP_000180410.1, NC_000921.1

3D structure databases

SMRiQ9ZLT1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9ZLT1, 1 interactor
STRINGi85963.jhp_0495

Genome annotation databases

EnsemblBacteriaiAAD06073; AAD06073; jhp_0495
KEGGihpj:jhp_0495

Phylogenomic databases

eggNOGiCOG1842, Bacteria
OMAiPNYKFNQ

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-537-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR005169, CagA
IPR004355, IVSec_CagA
PfamiView protein in Pfam
PF03507, CagA, 2 hits
PRINTSiPR01553, TYPE4SSCAGA

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAGA_HELPJ
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZLT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: December 2, 2020
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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