UniProtKB - Q9ZLT0 (MURI_HELPJ)
Protein
Glutamate racemase
Gene
murI
Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Functioni
Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation1 Publication
Catalytic activityi
- EC:5.1.1.3UniRule annotation3 Publications
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation1 PublicationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 70 | Proton donor/acceptorUniRule annotationBy similarity | 1 | |
Active sitei | 181 | Proton donor/acceptorUniRule annotationBy similarity | 1 |
GO - Molecular functioni
- glutamate racemase activity Source: UniProtKB-UniRule
- identical protein binding Source: IntAct
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniRule
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Isomerase |
Biological process | Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Enzyme and pathway databases
BioCyci | HPYL85963:G1G1A-540-MONOMER |
BRENDAi | 5.1.1.3, 2604 |
UniPathwayi | UPA00219 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:murIUniRule annotation Synonyms:glr Ordered Locus Names:jhp_0496 |
Organismi | Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) |
Taxonomic identifieri | 85963 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL5185 |
DrugBanki | DB08698, 1-[(3S)-5-PHENYL-3-THIOPHEN-2-YL-3H-1,4-BENZODIAZEPIN-2-YL]AZETIDIN-3-OL |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095477 | 1 – 255 | Glutamate racemaseAdd BLAST | 255 |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsBinary interactionsi
Q9ZLT0
With | #Exp. | IntAct |
---|---|---|
itself | 4 | EBI-15642574,EBI-15642574 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
DIPi | DIP-60299N |
STRINGi | 85963.jhp_0496 |
Chemistry databases
BindingDBi | Q9ZLT0 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9ZLT0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9ZLT0 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 8 | Substrate bindingUniRule annotationCombined sources3 Publications | 2 | |
Regioni | 39 – 40 | Substrate bindingUniRule annotationCombined sources3 Publications | 2 | |
Regioni | 71 – 72 | Substrate bindingUniRule annotationCombined sources3 Publications | 2 | |
Regioni | 182 – 183 | Substrate bindingUniRule annotationCombined sources3 Publications | 2 |
Sequence similaritiesi
Belongs to the aspartate/glutamate racemases family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0796, Bacteria |
OMAi | LDFFKPH |
Family and domain databases
HAMAPi | MF_00258, Glu_racemase, 1 hit |
InterProi | View protein in InterPro IPR015942, Asp/Glu/hydantoin_racemase IPR001920, Asp/Glu_race IPR018187, Asp/Glu_racemase_AS_1 IPR033134, Asp/Glu_racemase_AS_2 IPR004391, Glu_race |
PANTHERi | PTHR21198:SF2, PTHR21198:SF2, 1 hit |
Pfami | View protein in Pfam PF01177, Asp_Glu_race, 1 hit |
SUPFAMi | SSF53681, SSF53681, 2 hits |
TIGRFAMsi | TIGR00067, glut_race, 1 hit |
PROSITEi | View protein in PROSITE PS00923, ASP_GLU_RACEMASE_1, 1 hit PS00924, ASP_GLU_RACEMASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9ZLT0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIGVFDSGV GGFSVLKSLL KARLFDEIIY YGDSARVPYG TKDPTTIKQF
60 70 80 90 100
GLEALDFFKP HEIELLIVAC NTASALALEE MQKYSKIPIV GVIEPSILAI
110 120 130 140 150
KRQVEDKNAP ILVLGTKATI QSNAYDNALK QQGYLNISHL ATSLFVPLIE
160 170 180 190 200
ESILEGELLE TCMHYYFTPL EILPEVIILG CTHFPLIAQK IEGYFMGHFA
210 220 230 240 250
LPTPPLLIHS GDAIVEYLQQ KYALKNNACT FPKVEFHASG DVIWLERQAK
EWLKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001439 Genomic DNA Translation: AAD06074.1 |
PIRi | C71924 |
RefSeqi | WP_000690367.1, NZ_CP011330.1 |
Genome annotation databases
EnsemblBacteriai | AAD06074; AAD06074; jhp_0496 |
KEGGi | hpj:jhp_0496 |
PATRICi | fig|85963.30.peg.500 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001439 Genomic DNA Translation: AAD06074.1 |
PIRi | C71924 |
RefSeqi | WP_000690367.1, NZ_CP011330.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JFX | X-ray | 2.30 | A/B | 1-255 | [»] | |
2JFY | X-ray | 1.90 | A/B | 1-255 | [»] | |
2JFZ | X-ray | 1.86 | A/B | 1-255 | [»] | |
2W4I | X-ray | 1.87 | A/B/E/F | 1-255 | [»] | |
4B1F | X-ray | 2.05 | A/B | 1-255 | [»] | |
SMRi | Q9ZLT0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-60299N |
STRINGi | 85963.jhp_0496 |
Chemistry databases
BindingDBi | Q9ZLT0 |
ChEMBLi | CHEMBL5185 |
DrugBanki | DB08698, 1-[(3S)-5-PHENYL-3-THIOPHEN-2-YL-3H-1,4-BENZODIAZEPIN-2-YL]AZETIDIN-3-OL |
Genome annotation databases
EnsemblBacteriai | AAD06074; AAD06074; jhp_0496 |
KEGGi | hpj:jhp_0496 |
PATRICi | fig|85963.30.peg.500 |
Phylogenomic databases
eggNOGi | COG0796, Bacteria |
OMAi | LDFFKPH |
Enzyme and pathway databases
UniPathwayi | UPA00219 |
BioCyci | HPYL85963:G1G1A-540-MONOMER |
BRENDAi | 5.1.1.3, 2604 |
Miscellaneous databases
EvolutionaryTracei | Q9ZLT0 |
Family and domain databases
HAMAPi | MF_00258, Glu_racemase, 1 hit |
InterProi | View protein in InterPro IPR015942, Asp/Glu/hydantoin_racemase IPR001920, Asp/Glu_race IPR018187, Asp/Glu_racemase_AS_1 IPR033134, Asp/Glu_racemase_AS_2 IPR004391, Glu_race |
PANTHERi | PTHR21198:SF2, PTHR21198:SF2, 1 hit |
Pfami | View protein in Pfam PF01177, Asp_Glu_race, 1 hit |
SUPFAMi | SSF53681, SSF53681, 2 hits |
TIGRFAMsi | TIGR00067, glut_race, 1 hit |
PROSITEi | View protein in PROSITE PS00923, ASP_GLU_RACEMASE_1, 1 hit PS00924, ASP_GLU_RACEMASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MURI_HELPJ | |
Accessioni | Q9ZLT0Primary (citable) accession number: Q9ZLT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families