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Protein

Cadmium, zinc and cobalt-transporting ATPase

Gene

cadA

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell.

Catalytic activityi

ATP + H2O + Cd2+(In) = ADP + phosphate + Cd2+(Out).
ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Cadmium or zinc or cobaltPROSITE-ProRule annotation1
Metal bindingi14Cadmium or zinc or cobaltPROSITE-ProRule annotation1
Active sitei3884-aspartylphosphate intermediateBy similarity1
Metal bindingi583MagnesiumPROSITE-ProRule annotation1
Metal bindingi587MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Cadmium, Cobalt, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-776-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium, zinc and cobalt-transporting ATPase (EC:3.6.3.3, EC:3.6.3.5)
Gene namesi
Name:cadA
Ordered Locus Names:jhp_0727
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicBy similarityAdd BLAST72
Transmembranei73 – 92Helical; Name=1By similarityAdd BLAST20
Topological domaini93 – 102ExtracellularBy similarity10
Transmembranei103 – 124Helical; Name=2By similarityAdd BLAST22
Topological domaini125 – 131CytoplasmicBy similarity7
Transmembranei132 – 151Helical; Name=3By similarityAdd BLAST20
Topological domaini152 – 154ExtracellularBy similarity3
Transmembranei155 – 174Helical; Name=4By similarityAdd BLAST20
Topological domaini175 – 308CytoplasmicBy similarityAdd BLAST134
Transmembranei309 – 327Helical; Name=5By similarityAdd BLAST19
Topological domaini328 – 332ExtracellularBy similarity5
Transmembranei333 – 350Helical; Name=6By similarityAdd BLAST18
Topological domaini351 – 635CytoplasmicBy similarityAdd BLAST285
Transmembranei636 – 657Helical; Name=7By similarityAdd BLAST22
Topological domaini658 – 665ExtracellularBy similarity8
Transmembranei666 – 681Helical; Name=8By similarityAdd BLAST16
Topological domaini682 – 686CytoplasmicBy similarity5

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000461771 – 686Cadmium, zinc and cobalt-transporting ATPaseAdd BLAST686

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp0727

Structurei

3D structure databases

ProteinModelPortaliQ9ZL53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 63HMAPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
KOiK01534
OMAiAQVVIMN
OrthoDBiPOG091H00YH

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZL53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEYHIHNLD CPDCAAKLER DLNKLDYVKK AQINFSTSKL FLDTSDFEKV
60 70 80 90 100
KAFIKQNEPH LSLSFKEAAE KPLSFTPLIA TIAVFLGAIL ILHLEPSPFI
110 120 130 140 150
EKAVFVVLAL VYLISGKDVI LGAFRGLRKG QFFDENALML IATIAAFCVG
160 170 180 190 200
AYEESVSIMV FYSAGEFLQI LAIARSKKSL KALVDVAPNL AYLKKGDTLV
210 220 230 240 250
SVAPEDLRIN DIVVVKVGEK VPVDGVVIKG ESLLDERALS GESMPVNVSE
260 270 280 290 300
RSKVLGGSLN LKAVLEIQVE KLYKDSSIAK VVDLVQQATN EKSETEKFIT
310 320 330 340 350
KFSRYYTPSV LFIALMIAVL PPLFSMGSFD EWIYRGLVAL MVSCPCALVI
360 370 380 390 400
SVPLGYFGGV GAASRKGILM KGVHVLEVLT QTKSIAFDKT GTLTKGVFKV
410 420 430 440 450
VDIVPQNGHS KEEVLHYASC SQLLSTHPIA LSIQKACEEM LKDDKHQHDI
460 470 480 490 500
KNYEELSGMG VKAQCHTDLI IAGNEKMLDQ FHIAHSPSPE NGTIVHVAFN
510 520 530 540 550
QTYIGYIVIS DEIKDDAIEC LRDLKAQGIE NFCILSGDRK SATESIARTL
560 570 580 590 600
GCEYHASLLP EEKTSVFKTF KERYKAPAIF VGDGINDAPT LASADVGIGM
610 620 630 640 650
GKGSELSKQS ADIVITNDSL SSLVKVLAIA KKTKSIIWQN ILFALGIKAV
660 670 680
FIVLGLMGVA SLWEAVFGDV GVTLLALANS MRTMRA
Length:686
Mass (Da):74,837
Last modified:May 1, 1999 - v1
Checksum:i01E39A3B057476E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06308.1
PIRiE71895
RefSeqiWP_001158764.1, NC_000921.1

Genome annotation databases

EnsemblBacteriaiAAD06308; AAD06308; jhp_0727
KEGGihpj:jhp_0727

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD06308.1
PIRiE71895
RefSeqiWP_001158764.1, NC_000921.1

3D structure databases

ProteinModelPortaliQ9ZL53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi85963.jhp0727

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD06308; AAD06308; jhp_0727
KEGGihpj:jhp_0727

Phylogenomic databases

eggNOGiENOG4105C59 Bacteria
COG2217 LUCA
KOiK01534
OMAiAQVVIMN
OrthoDBiPOG091H00YH

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-776-MONOMER

Family and domain databases

CDDicd00371 HMA, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
IPR027256 P-typ_ATPase_IB
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00403 HMA, 1 hit
PRINTSiPR00941 CDATPASE
SUPFAMiSSF55008 SSF55008, 1 hit
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01525 ATPase-IB_hvy, 1 hit
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHMCT_HELPJ
AccessioniPrimary (citable) accession number: Q9ZL53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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