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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei6SubstrateBy similarity1
Metal bindingi29Divalent metal cationBy similarity1
Active sitei31Proton acceptorBy similarity1
Metal bindingi31Divalent metal cationBy similarity1
Metal bindingi62Divalent metal cationBy similarity1
Binding sitei62SubstrateBy similarity1
Active sitei171Proton donorBy similarity1
Metal bindingi171Divalent metal cationBy similarity1
Binding sitei173Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandCobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciHPYL85963:G1G1A-1546-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:jhp_1439
OrganismiHelicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
Taxonomic identifieri85963 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000804 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001715731 – 217Ribulose-phosphate 3-epimeraseAdd BLAST217

Interactioni

Protein-protein interaction databases

STRINGi85963.jhp1439

Structurei

3D structure databases

ProteinModelPortaliQ9ZJ75
SMRiQ9ZJ75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 141Substrate bindingBy similarity4
Regioni193 – 194Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV Bacteria
COG0036 LUCA
KOiK01783
OMAiNCETMLE
OrthoDBiPOG091H01TC

Family and domain databases

CDDicd00429 RPE, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR026019 Ribul_P_3_epim
IPR000056 Ribul_P_3_epim-like
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR11749 PTHR11749, 1 hit
PfamiView protein in Pfam
PF00834 Ribul_P_3_epim, 1 hit
PIRSFiPIRSF001461 RPE, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01163 rpe, 1 hit
PROSITEiView protein in PROSITE
PS01085 RIBUL_P_3_EPIMER_1, 1 hit
PS01086 RIBUL_P_3_EPIMER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZJ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAPSLLSA DFMHLAKEIE SVSNADFLHV DVMDGHYVPN LTMGPVILEN
60 70 80 90 100
VTQMSQVPLD VHLMVENASF FVELFAPLNP QIISIHAENE KHPHRVLQLI
110 120 130 140 150
KSSGITPGIV LNPHTHEESI KYLLESVGLV LLMSVNPGFG GQKFLDLVLE
160 170 180 190 200
KCLKVKELIK RYNPSCLLEV DGGVNDKNIF ELQQAGVDVV VSGSYIFESK
210
DRKLAIEGLQ NVRQPLA
Length:217
Mass (Da):24,031
Last modified:May 1, 1999 - v1
Checksum:i7363839BACF4A989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001439 Genomic DNA Translation: AAD07015.1
PIRiG71807
RefSeqiWP_000861417.1, NZ_CP011330.1

Genome annotation databases

EnsemblBacteriaiAAD07015; AAD07015; jhp_1439
KEGGihpj:jhp_1439
PATRICifig|85963.30.peg.1105

Similar proteinsi

Entry informationi

Entry nameiRPE_HELPJ
AccessioniPrimary (citable) accession number: Q9ZJ75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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