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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus carnosus (strain TM300)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18GTPUniRule annotation1
Binding sitei65GTPUniRule annotation1
Metal bindingi97MagnesiumUniRule annotation1
Binding sitei97GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 8GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSCAR396513:G1G1Q-1801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Sca_1757
OrganismiStaphylococcus carnosus (strain TM300)
Taxonomic identifieri396513 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000444 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001349171 – 197Probable molybdenum cofactor guanylyltransferaseAdd BLAST197

Interactioni

Protein-protein interaction databases

STRINGi396513.Sca_1757.

Structurei

3D structure databases

ProteinModelPortaliQ9ZIM7.
SMRiQ9ZIM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082CS. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280425.
KOiK03752.
OMAiSVCYVQA.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ZIM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIILAGGQ SERFGAPKAF AEIDGKMFYE QIITVLDSMN MFNEIIISSN
60 70 80 90 100
ETLASEFKGA RVIVDDSEHK NKGPLSGIYS VMKQDFESEL FFVISVDTPL
110 120 130 140 150
ITAKAISQLY QFMVEHVIED QLDIAGFKEG NHPIPTIAFY SPNCLPIIAR
160 170 180 190
ALESDDYSMR HVYQQTASDW IDVSSVDDDT EWYKNINYPQ DLESIKK
Length:197
Mass (Da):22,277
Last modified:May 5, 2009 - v2
Checksum:i82D26BDC2F78E364
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86 – 103FESEL…PLITA → LNQNYFCDFCGYAAYYR in AAC83143 (PubMed:9675851).CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109295 Genomic DNA. Translation: AAC83143.1.
AM295250 Genomic DNA. Translation: CAL28663.1.
RefSeqiWP_015900999.1. NC_012121.1.

Genome annotation databases

KEGGisca:SCA_1757.

Similar proteinsi

Entry informationi

Entry nameiMOBA_STACT
AccessioniPrimary (citable) accession number: Q9ZIM7
Secondary accession number(s): B9DLY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 5, 2009
Last modified: February 28, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome