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Protein

Cell cycle response regulator CtrA

Gene

ctrA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a regulatory phosphorelay system that controls B.abortus cell growth, division, and intracellular survival inside mammalian host cells. This signaling pathway is composed of CckA, ChpT, CtrA and CpdR. CtrA is a response regulator substrate of ChpT (By similarity). When phosphorylated, directly regulates the expression of ccrM. Is also probably involved in the transcriptional regulation of rpoD, pleC, minC and ftsE genes (PubMed:11929544).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi124 – 223OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Cell cycle response regulator CtrA
Alternative name(s):
Cell cycle transcriptional regulator A1 Publication
Gene namesi
Name:ctrA
Ordered Locus Names:BruAb1_1586
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Lethal.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi51D → E: No phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003631971 – 232Cell cycle response regulator CtrAAdd BLAST232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

Is phosphorylated by ChpT-P on Asp-51.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms an asymmetric heterotetramer with ChpT (2:2). There are at least two modes of interaction between ChpT and CtrA, only one of which is competent to catalyze His-Asp phosphoryl transfer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9ZHS1
SMRiQ9ZHS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST115

Phylogenomic databases

HOGENOMiHOG000034815
KOiK13584
OMAiDMVMSMQ

Family and domain databases

CDDicd00156 REC, 1 hit
cd00383 trans_reg_C, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR001867 OmpR/PhoB-type_DNA-bd
IPR001789 Sig_transdc_resp-reg_receiver
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00072 Response_reg, 1 hit
PF00486 Trans_reg_C, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SM00862 Trans_reg_C, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51755 OMPR_PHOB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZHS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL
60 70 80 90 100
DLNLPDMSGY EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT
110 120 130 140 150
KPFHKDELIA RIHAIVRRSK GHAQSVITTG DLVVNLDAKT VEVAGQRVHL
160 170 180 190 200
TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG GMDEPELKII DVFICKLRKK
210 220 230
LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
Length:232
Mass (Da):26,066
Last modified:May 1, 1999 - v1
Checksum:i9177C2281EC76ACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051939 mRNA Translation: AAC69920.1
AF411570 Genomic DNA Translation: AAL86376.1
AE017223 Genomic DNA Translation: AAX74911.1
PIRiAI3304
RefSeqiWP_002964699.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX74911; AAX74911; BruAb1_1586
GeneIDi29593201
KEGGibmb:BruAb1_1586

Similar proteinsi

Entry informationi

Entry nameiCTRA_BRUAB
AccessioniPrimary (citable) accession number: Q9ZHS1
Secondary accession number(s): Q57BS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names

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