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Protein

DNA polymerase III PolC-type

Gene

polC

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase III PolC-typeUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
PolIIIUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:polCUniRule annotation
Ordered Locus Names:TM_0576
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243274 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008183 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002046051 – 1367DNA polymerase III PolC-typeAdd BLAST1367

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9ZHF6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
243274.TM0576

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9ZHF6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ZHF6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9ZHF6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini358 – 513ExonucleaseAdd BLAST156

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-C family. PolC subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DE5 Bacteria
COG2176 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZHF6

KEGG Orthology (KO)

More...
KOi
K03763

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYAAYFT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00356 DNApol_PolC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR029460 DNAPol_HHH
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZHF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKIENLKWK NVSFKSLEID PDAGVVLVSV EKFSEEIEDL VRLLEKKTRF
60 70 80 90 100
RVIVNGVQKS NGDLRGKILS LLNGNVPYIK DVVFEGNRLI LKVLGDFARD
110 120 130 140 150
RIASKLRSTK KQLDELLPPG TEIMLEVVEP PEDLLKKEVP QPEKREEPKG
160 170 180 190 200
EELKIEDENH IFGQKPRKIV FTPSKIFEYN KKTSVKGKIF KIEKIEGKRT
210 220 230 240 250
VLLIYLTDGE DSLICKVFND VEKVEGKVSV GDVIVATGDL LLENGEPTLY
260 270 280 290 300
VKGITKLPEA KRMDKSPVKR VELHAHTKFS DQDAITDVNE YVKRAKEWGF
310 320 330 340 350
PAIALTDHGN VQAIPYFYDA AKEAGIKPIF GIEAYLVSDV EPVIRNLSDD
360 370 380 390 400
STFGDATFVV LDFETTGLDP QVDEIIEIGA VKIQGGQIVD EYHTLIKPSR
410 420 430 440 450
EISRKSSEIT GITQEMLENK RSIEEVLPEF LGFLEDSIIV AHNANFDYRF
460 470 480 490 500
LRLWIKKVMG LDWERPYIDT LALAKSLLKL RSYSLDSVVE KLGLGPFRHH
510 520 530 540 550
RALDDARVTA QVFLRFVEMM KKIGITKLSE MEKLKDTIDY TALKPFHCTI
560 570 580 590 600
LVQNKKGLKN LYKLVSDSYI KYFYGVPRIL KSELIENREG LLVGSACISG
610 620 630 640 650
ELGRAALEGA SDSELEEIAK FYDYIEVMPL DVIAEDEEDL DRERLKEVYR
660 670 680 690 700
KLYRIAKKLN KFVVMTGDVH FLDPEDARGR AALLAPQGNR NFENQPALYL
710 720 730 740 750
RTTEEMLEKA IEIFEDEEIA REVVIENPNR IADMIEEVQP LEKKLHPPII
760 770 780 790 800
ENADEIVRNL TMKRAYEIYG DPLPEIVQKR VEKELNAIIN HGYAVLYLIA
810 820 830 840 850
QELVQKSMSD GYVVGSRGSV GSSLVANLLG ITEVNPLPPH YRCPECKYFE
860 870 880 890 900
VVEDDRYGAG YDLPNKNCPR CGAPLRKDGH GIPFETFMGF EGDKVPDIDL
910 920 930 940 950
NFSGEYQERA HRFVEELFGK DHVYRAGTIN TIAERSAVGY VRSYEEKTGK
960 970 980 990 1000
KLRKAEMERL VSMITGVKRT TGQHPGGLMI IPKDKEVYDF TPIQYPANDR
1010 1020 1030 1040 1050
NAGVFTTHFA YETIHDDLVK IDALGHDDPT FIKMLKDLTG IDPMTIPMDD
1060 1070 1080 1090 1100
PDTLAIFSSV KPLGVDPVEL ESDVGTYGIP EFGTEFVRGM LVETRPKSFA
1110 1120 1130 1140 1150
ELVRISGLSH GTDVWLNNAR DWINLGYAKL SEVISCRDDI MNFLIHKGME
1160 1170 1180 1190 1200
PSLAFKIMEN VRKGKGITEE MESEMRRLKV PEWFIESCKR IKYLFPKAHA
1210 1220 1230 1240 1250
VAYVSMAFRI AYFKVHYPLQ FYAAYFTIKG DQFDPVLVLR GKEAIKRRLR
1260 1270 1280 1290 1300
ELKAMPAKDA QKKNEVSVLE VALEMILRGF SFLPPDIFKS DAKKFLIEGN
1310 1320 1330 1340 1350
SLRIPFNKLP GLGDSVAESI IRAREEKPFT SVEDLMKRTK VNKNHIELMK
1360
SLGVLGDLPE TEQFTLF
Length:1,367
Mass (Da):155,363
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE5916FA70591F84
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF065313 Genomic DNA Translation: AAC80438.1
AE000512 Genomic DNA Translation: AAD35661.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C72360

NCBI Reference Sequences

More...
RefSeqi
NP_228386.1, NC_000853.1
WP_004081285.1, NZ_CP011107.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD35661; AAD35661; TM_0576

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
897644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
tma:TM0576

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF065313 Genomic DNA Translation: AAC80438.1
AE000512 Genomic DNA Translation: AAD35661.1
PIRiC72360
RefSeqiNP_228386.1, NC_000853.1
WP_004081285.1, NZ_CP011107.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P1JX-ray2.50A/B347-522[»]
ProteinModelPortaliQ9ZHF6
SMRiQ9ZHF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0576

Proteomic databases

PRIDEiQ9ZHF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35661; AAD35661; TM_0576
GeneIDi897644
KEGGitma:TM0576

Phylogenomic databases

eggNOGiENOG4105DE5 Bacteria
COG2176 LUCA
InParanoidiQ9ZHF6
KOiK03763
OMAiYYAAYFT

Miscellaneous databases

EvolutionaryTraceiQ9ZHF6

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00356 DNApol_PolC, 1 hit
InterProiView protein in InterPro
IPR011708 DNA_pol3_alpha_NTPase_dom
IPR029460 DNAPol_HHH
IPR006054 DnaQ
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR004013 PHP_dom
IPR003141 Pol/His_phosphatase_N
IPR006308 PolC_gram_pos
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF07733 DNA_pol3_alpha, 1 hit
PF14579 HHH_6, 1 hit
PF02811 PHP, 1 hit
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SM00481 POLIIIAc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00573 dnaq, 1 hit
TIGR01405 polC_Gram_pos, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPO3_THEMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZHF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: December 5, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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