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Entry version 87 (02 Jun 2021)
Sequence version 2 (27 Jul 2011)
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Protein

Type IV pilus biogenesis and competence protein PilQ

Gene

pilQ

Organism
Neisseria meningitidis serogroup B / serotype 15 (strain H44/76)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCompetence, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
NMEN909420:NMBH4476_RS09750-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.22.2.2, the outer bacterial membrane secretin (secretin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type IV pilus biogenesis and competence protein PilQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pilQ
Ordered Locus Names:NMBH4476_1758
ORF Names:NMH_1547
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidis serogroup B / serotype 15 (strain H44/76)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri909420 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000032707 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001311825 – 777Type IV pilus biogenesis and competence protein PilQAdd BLAST753

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homododecamer. Tetramer of trimer (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q9ZHF3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9ZHF3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni135 – 156DisorderedSequence analysisAdd BLAST22
Regioni197 – 236DisorderedSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006756_0_1_4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNVPWDQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021731, AMIN_dom
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11741, AMIN, 1 hit
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit
PF07660, STN, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00811, BCTERIALGSPD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00965, STN, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02515, IV_pilus_PilQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00875, T2SP_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ZHF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTKLTKIIS GLFVATAAFQ TASAGNITDI KVSSLPNKQK IVKVSFDKEI
60 70 80 90 100
VNPTGFVTSS PARIALDFEQ TGISMDQQVL EYADPLLSKI SAAQNSSRAR
110 120 130 140 150
LVLNLNKPGQ YNTEVRGNKV WIFINESDDT VSAPARPAVK AAPAAPAKQQ
160 170 180 190 200
AAAPSTKSAV SVSEPFTPAK QQAAAPFTES VVSVSAPFSP AKQQAAASAK
210 220 230 240 250
QQAAAPAKQQ AAAPAKQQAA APAKQQAAAP AKQTNIDFRK DGKNAGIIEL
260 270 280 290 300
AALGFAGQPD ISQQHDHIIV TLKNHTLPTT LQRSLDVADF KTPVQKVTLK
310 320 330 340 350
RLNNDTQLII TTAGNWELVN KSAAPGYFTF QVLPKKQNLE SGGVNNAPKT
360 370 380 390 400
FTGRKISLDF QDVEIRTILQ ILAKESGMNI VASDSVNGKM TLSLKDVPWD
410 420 430 440 450
QALDLVMQAR NLDMRQQGNI VNIAPRDELL AKDKALLQAE KDIADLGALY
460 470 480 490 500
SQNFQLKYKN VEEFRSILRL DNADTTGNRN TLISGRGSVL IDPATNTLIV
510 520 530 540 550
TDTRSVIEKF RKLIDELDVP AQQVMIEARI VEAADGFSRD LGVKFGATGK
560 570 580 590 600
KKLKNDTSAF GWGVNSGFGG DDKWGAETKI NLPITAAANS ISLVRAISSG
610 620 630 640 650
ALNLELSASE SLSKTKTLAN PRVLTQNRKE AKIESGYEIP FTVTSIANGG
660 670 680 690 700
SSTNTELKKA VLGLTVTPNI TPDGQIIMTV KINKDSPAQC ASGNQTILCI
710 720 730 740 750
STKNLNTQAM VENGGTLIVG GIYEEDNGNT LTKVPLLGDI PVIGNLFKTR
760 770
GKKTDRRELL IFITPRIMGT AGNSLRY
Length:777
Mass (Da):83,239
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB14F906477DBA6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti214P → S in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti280T → A in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti387N → S in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti423I → M in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti427 – 469DELLA…RSILR → RAACQRQSLLTTGKRHCRSG RAVFPKLPIEIQKCGRIPQH PA in AAC96097 (PubMed:9701807).CuratedAdd BLAST43
Sequence conflicti483I → V in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti550K → R in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti556D → E in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti571D → G in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti575 – 598GAETK…VRAIS → EAKPKSTCRLPCRKQHFAGA RDF in AAC96097 (PubMed:9701807).CuratedAdd BLAST24
Sequence conflicti615T → P in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti646 – 648IAN → RSG in AAC96097 (PubMed:9701807).Curated3
Sequence conflicti688A → R in AAC96097 (PubMed:9701807).Curated1
Sequence conflicti738 – 777GDIPV…NSLRY → ATSPLSATSLKHGEKNRPPR TADFQLPPREL in AAC96097 (PubMed:9701807).CuratedAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF066056 Genomic DNA Translation: AAC96097.1
AEQZ01000037 Genomic DNA Translation: EFV63384.1
CP002420 Genomic DNA Translation: ADY96329.1

NCBI Reference Sequences

More...
RefSeqi
WP_009348000.1, NZ_AEQZ01000037.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
EFV63384; EFV63384; NMH_1547

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nmh:NMBH4476_1758

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|909420.3.peg.2335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF066056 Genomic DNA Translation: AAC96097.1
AEQZ01000037 Genomic DNA Translation: EFV63384.1
CP002420 Genomic DNA Translation: ADY96329.1
RefSeqiWP_009348000.1, NZ_AEQZ01000037.1

3D structure databases

BMRBiQ9ZHF3
SMRiQ9ZHF3
ModBaseiSearch...

Protein family/group databases

TCDBi1.B.22.2.2, the outer bacterial membrane secretin (secretin) family

Genome annotation databases

EnsemblBacteriaiEFV63384; EFV63384; NMH_1547
KEGGinmh:NMBH4476_1758
PATRICifig|909420.3.peg.2335

Phylogenomic databases

HOGENOMiCLU_006756_0_1_4
OMAiQNVPWDQ

Enzyme and pathway databases

BioCyciNMEN909420:NMBH4476_RS09750-MONOMER

Family and domain databases

Gene3Di3.30.1370.120, 1 hit
InterProiView protein in InterPro
IPR021731, AMIN_dom
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS
PfamiView protein in Pfam
PF11741, AMIN, 1 hit
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit
PF07660, STN, 1 hit
PRINTSiPR00811, BCTERIALGSPD
SMARTiView protein in SMART
SM00965, STN, 1 hit
TIGRFAMsiTIGR02515, IV_pilus_PilQ, 1 hit
PROSITEiView protein in PROSITE
PS00875, T2SP_D, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPILQ_NEIMH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZHF3
Secondary accession number(s): E6MYG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 87 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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