Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102NADPBy similarity1
Binding sitei102SubstrateBy similarity1
Active sitei182Proton acceptorBy similarity1
Active sitei189Proton donorBy similarity1
Binding sitei190SubstrateBy similarity1
Binding sitei260Substrate; via amide nitrogenBy similarity1
Binding sitei287SubstrateBy similarity1
Binding sitei446Substrate; shared with dimeric partnerBy similarity1
Binding sitei452Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADPBy similarity6
Nucleotide bindingi33 – 35NADPBy similarity3
Nucleotide bindingi74 – 76NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

BioCyciBAPH198804:G1FZU-111-MONOMER
UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:BUsg_100
OrganismiBuchnera aphidicola subsp. Schizaphis graminum (strain Sg)
Taxonomic identifieri198804 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera
Proteomesi
  • UP000000416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900291 – 4736-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST473

Proteomic databases

PRIDEiQ9ZHD9

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198804.BUsg100

Structurei

3D structure databases

ProteinModelPortaliQ9ZHD9
SMRiQ9ZHD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 130Substrate bindingBy similarity3
Regioni185 – 186Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C7Q Bacteria
COG0362 LUCA
KOiK00033
OMAiNSHYPDS
OrthoDBiPOG091H01QF

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZHD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQQVGVIG MAVMGRNLAL NIESKKYTVS IFNRTQSVTE EVINNNKEKK
60 70 80 90 100
IFPYFSIKDF VNSLRKPRCI LLMVKSGQPT DETIQFILPY LNKGDILIDG
110 120 130 140 150
GNTFYKDSIR RSNDLMKCGI NFIGMGVSGG ELGALNGPSI MPGGSREAYD
160 170 180 190 200
LVSSMLKKIS AKFKNEPCVS YIGPNGAGHY VKMIHNGIEY GDMQLISESY
210 220 230 240 250
FILKNVLNMK NEELSNTFSQ WNKGELNSYL IEITKNIFLK KEKDGIHYLI
260 270 280 290 300
DSILDHAEDK GTGKWISQDA LELHEPLSLI TESVFARYLS SLKDQRLIAS
310 320 330 340 350
KILKGPILKC ISSQNKELFV EEVRRALYLG KIISYAQGFS QLKKASEKYS
360 370 380 390 400
WNLQYGKIAK IFRAGCIIRA DFLERITDAF KSNNVTNLLL TPYFSEISNK
410 420 430 440 450
YEKSLRYITS YAIKYGIPVP TFASAISYYD NYRTMSSSAN LIQAQRDYFG
460 470
AHTYRRTDKK GYFHTNWLTK KEL
Length:473
Mass (Da):53,805
Last modified:August 30, 2002 - v2
Checksum:iA11842A037E1E984
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158K → N in AAC97362 (PubMed:9767718).Curated1
Sequence conflicti324 – 326RRA → TKS in AAC97362 (PubMed:9767718).Curated3
Sequence conflicti348K → I in AAC97362 (PubMed:9767718).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067228 Genomic DNA Translation: AAC97362.1
AE013218 Genomic DNA Translation: AAM67670.1
RefSeqiWP_011053636.1, NC_004061.1

Genome annotation databases

EnsemblBacteriaiAAM67670; AAM67670; BUsg_100
KEGGibas:BUsg_100

Similar proteinsi

Entry informationi

Entry namei6PGD_BUCAP
AccessioniPrimary (citable) accession number: Q9ZHD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 30, 2002
Last modified: February 28, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Buchnera aphidicola (subsp. Schizaphis graminum)
    Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health