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Entry version 115 (11 Dec 2019)
Sequence version 1 (01 May 1999)
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Protein
Submitted name:

FK506 polyketide synthase

Gene

fkbB

Organism
Streptomyces sp. MA6548
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FK506 polyketide synthaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fkbBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces sp. MA6548Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri82632 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1130O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2715O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4355O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5938O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei7485O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1095 – 1170CarrierInterPro annotationAdd BLAST76
Domaini2680 – 2755CarrierInterPro annotationAdd BLAST76
Domaini4320 – 4395CarrierInterPro annotationAdd BLAST76
Domaini5903 – 5978CarrierInterPro annotationAdd BLAST76
Domaini7450 – 7525CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni959 – 980DisorderedSequence analysisAdd BLAST22
Regioni2127 – 2154DisorderedSequence analysisAdd BLAST28
Regioni2322 – 2344DisorderedSequence analysisAdd BLAST23
Regioni7408 – 7441DisorderedSequence analysisAdd BLAST34
Regioni7529 – 7556DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2129 – 2154PolarSequence analysisAdd BLAST26

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 5 hits
3.10.129.110, 4 hits
3.40.366.10, 4 hits
3.40.47.10, 4 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 4 hits
PF08240 ADH_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PF16197 KAsynt_C_assoc, 4 hits
PF00109 ketoacyl-synt, 4 hits
PF02801 Ketoacyl-synt_C, 4 hits
PF08659 KR, 3 hits
PF00550 PP-binding, 5 hits
PF14765 PS-DH, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 4 hits
SM00826 PKS_DH, 4 hits
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 4 hits
SM00823 PKS_PP, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 5 hits
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 8 hits
SSF52151 SSF52151, 4 hits
SSF53901 SSF53901, 4 hits
SSF55048 SSF55048, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 4 hits
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZGA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAESIRPL HELLRVNAER HGDRVAYTDS RRAVTYGRLQ LRTGRIAGHL
60 70 80 90 100
AASGVGRGDR VRLLLGNRIE TIEVYLAAAR AAAVAVPLNP DAGDAELAHF
110 120 130 140 150
LTDSGATVLV TDDLHLDQVR RVGTDATVVL AGRREPGCVA YEDLAGTEPP
160 170 180 190 200
RPPRDDLGLD EPAWMLYTSG TTGRPKGVVS AQRSGLWSAT YCDVPSWELT
210 220 230 240 250
EDDELLWPAP LFHSLGHHLC LLAVLTVGAS ARILGGFVAR DVLDALAEHP
260 270 280 290 300
CTVLVGVPTM YRYLLGAVSG EPQTRALRVA LVAGSTSPAS LTAGFEAAFG
310 320 330 340 350
VPLLDTYGCT ETTGSLTANT LTDTRVPGSC GLPVPGLSLR FVDPVTGADV
360 370 380 390 400
RRGDEGELWA SGPSLMLGYH AQTEATAQVL ADGWYRTGDL ARQAETGHVT
410 420 430 440 450
ITGRVKELII RGGENIHPRE IESVAQEVPG VRDAAAAGRP HPVLGEIPVL
460 470 480 490 500
YVVPEGPVVP ADAILAECRR QLAYFKVPDE ILHVTTVPRT ASGKVRRGEL
510 520 530 540 550
AGLPARLVGT GSGEAALCEL VWERRELPDT VSQVQAVVTR RAVGIGPAEV
560 570 580 590 600
PDADQALRWD EALVRQAAEP GSFVLVDTDT DTDTDANNGD EADELVAAAA
610 620 630 640 650
ALGEPQVALR SGVAYVPRLV RADTTPLPAS QWALRPPASG TLRDLAVAPS
660 670 680 690 700
DAPPRPLAAG EVRVDVRAAG LNFRDVLIAL GTYPGDGAMG GEAAGIVTEV
710 720 730 740 750
GPGVDDLVPG AHVFGLVQDA FRRSVVADRR LVARIPRGWS FPVAASVPIV
760 770 780 790 800
FATAWYGLVD AGQVRPGQKV LIHAATGGVG SAARQIARHM GADVYATASP
810 820 830 840 850
AKQHLLLADG FDADHVANSR TTAFADAFPP VDVVLNSLTG EFLDASVELL
860 870 880 890 900
APGGRFIEMG KTDIRHDVQQ PFDLSDVDPA RLREILELLL ELFDRDELRP
910 920 930 940 950
LPVRPWDIRR ARDAFGWMSQ ARNTGKTVLT VPRPLGPDAP VLVTGEGADA
960 970 980 990 1000
VAGLLRDETG RTHVSSSAAE AERAEEGEEG VNASTLAHVL LGDPAGADAY
1010 1020 1030 1040 1050
ARSRASEGLP IVTVHGLPGI EQAALTGELI EAAIEGGGSY VVTRVGSAGA
1060 1070 1080 1090 1100
RAEAMAGATP PILSGLAGPT GRAEPGAAGP EWGSRLAAAD ADRENVLLDL
1110 1120 1130 1140 1150
VRDSVATVLG LPGAERCAPD RTFRENGLDS LTTVEFANTV AARTGLRVPA
1160 1170 1180 1190 1200
STAFDHPTPR SFAAHLAGSV AAPAAKAALG SGEPVAIVGM ACRLPGGVTS
1210 1220 1230 1240 1250
PEGLWRLVAS GTDAITEFPV DRGWDVDELV DPDPDAVGRS TTRHGGFLTE
1260 1270 1280 1290 1300
ATGFDAAFFG ISPNEALAMD PQQRLVLETS WEAFEHAGIV PDTLRESDTG
1310 1320 1330 1340 1350
VFMGAFHQGY GAGRDLGGLG VTATQTSVLS GRLSYFYGLQ GPAVTVDTAC
1360 1370 1380 1390 1400
SSSLVALHQA AQALRSGECS LALAGGVTVM ATPGSFVEFS RQRGLSPDGR
1410 1420 1430 1440 1450
CKAFADAADG TGFAEGVGVL VVERQSDAER NGHTVLAVVR GSAVNQDGAS
1460 1470 1480 1490 1500
NGLSAPNGVA QQRVIRQALA NAGLSGADVD AVEAHGTGTV LGDPIEAQAV
1510 1520 1530 1540 1550
LASYGQEREV PLLLGSVKSN VGHTQAAAGV AGVIKMVMAM RHGLLPKTLH
1560 1570 1580 1590 1600
VDEPSSHVDW SAGAVEVVTE TRPWPESGGA RRAGVSSFGV SGTNAHVILE
1610 1620 1630 1640 1650
GVAESSVRDG GSSGLVPLPV SARTESSLAL QVERLGEYVR GGADAAAVAD
1660 1670 1680 1690 1700
GLVRGRAVFD RRAVLLGESA VAGVAVEGAR TVFVFPGQGS QWVGMGRELM
1710 1720 1730 1740 1750
GASEVFAARM RECAAVLEPH TGWDLLDVLG EAVVVDRVEV LQPASWAVAV
1760 1770 1780 1790 1800
SLAALWQAHG VVPDAVVGHS QGEIAAACVA GALSLEDAAR VVALRSQAIA
1810 1820 1830 1840 1850
ARLAGRGAMA SIAVPASAVE TVEGVWIAAR NGPESTVVAG DPAAVERVLA
1860 1870 1880 1890 1900
RYEAEGVRVR RIAVDYASHT PHVEAIEAQL ADALEGITSS TPSVPWWSTV
1910 1920 1930 1940 1950
DSGWVTEPFG DAYWYRNLRQ PVAMDTAVSE LDGSLFIECS AHPVLLPALD
1960 1970 1980 1990 2000
QERTVASLRT DDGGWDRFLA ALAQAWTQGA DVDWTTLIEP APHRVLDLPT
2010 2020 2030 2040 2050
YPFDHKRYWL QPAPVTGAGI GHPFLSSAAV LPGSDGVLLT GKLSLATHPW
2060 2070 2080 2090 2100
LADHTVQEVV LLPGTAFLEL VVRAGDEVGC DTIDELVIET PHSLPASGAV
2110 2120 2130 2140 2150
DLTVTVDQPD DTGHRPVSVH ARPAGTDTWT RHATGTLGRT EDTAPDTNSF
2160 2170 2180 2190 2200
PQWPPTGAQP ASLDEFYERL AGAGYTYGPA FQGLRAAWRA GDTVYAEVAL
2210 2220 2230 2240 2250
DGAADVDRFG VHPALLDAAL HAGRLDAGDE LELPFSWTGV RLHATGAAAV
2260 2270 2280 2290 2300
RVAHSRGPAG VAVQVADLDG RPVVSVDALV LRPRSVAPSG PNLLGLEWLP
2310 2320 2330 2340 2350
VAEAHYDGAD ELPEGYTLIT ATHPDDPDDD PTNPHNTPTR THTQTTRVLT
2360 2370 2380 2390 2400
ALQHHLTTTN HTLIVHTTTD PPGAAVTGLT RTAQNEHPGR IHLIETHHPH
2410 2420 2430 2440 2450
TPLPLTQLTT LHQPHLRLTN NTLHTPHLTP ITTHHNTTTT TPNTPPLNPN
2460 2470 2480 2490 2500
HAILITGGSG TLAGILARHL NHPLTYLLSR TPPPPTTPRT HIPCDLTDPT
2510 2520 2530 2540 2550
QITQALTHIP QPLTGIFHTA ATHDDATLTN LTPQHLTTTL QPKADAAWHL
2560 2570 2580 2590 2600
HHHTQNQPLT HFVLYSSAAA TLGSPGQANY AAANAFLDAL ATHRHTQGQP
2610 2620 2630 2640 2650
ATTIAWGMWH TTTTLTSQLT DTERQQVRDG FRPLTEAEGN HFLDASLATD
2660 2670 2680 2690 2700
APFVVAAIPA EPARRRVERR TARTGEDSGR DLLAVVCVAT AAVLGHADAS
2710 2720 2730 2740 2750
EIGAATAFKD LGIDSLSGIR LRNSLAEATG VRLSATAVFD HPTPDALAAR
2760 2770 2780 2790 2800
LAEELRGDDD SQGAAAAAAA PGTVPTVAAA GDEPLAIVAM ACRMPGGVDT
2810 2820 2830 2840 2850
PEDLWSLVES GGDAITEFPT DRGWDLAALY DPDPDAIGKV SVRHGGFLSG
2860 2870 2880 2890 2900
AADFDAEFFG ISPREALAMD PQQRLVLEVS WEAFERAGIL PASVRGSDAG
2910 2920 2930 2940 2950
VFMGAFTQGY GAGVDLGGFG ATGTPTSVLS GRLSYYFGLE GPSVTVDTAC
2960 2970 2980 2990 3000
SSSLVALHQA ARSLRSGECS LALVGGVTVM ATTTGFVEFS RQRGLAPDGR
3010 3020 3030 3040 3050
AKAFADTADG TSFAEGAGVL IVERLSDATR LGHPVLAVVR GSAVNSDGAS
3060 3070 3080 3090 3100
NGLSAPNGPA QQRVIERALD DAGLAPGDID AVEAHGTGTR LGDPIEAQAL
3110 3120 3130 3140 3150
EAAYGLDRLH PLLIGSLKSN FGHTQAAAGV AGVIKMVLAM RHGVLPRTLH
3160 3170 3180 3190 3200
VDEPSRHVDW GGDVRLLRRN EPWPVTGRVR RAGVSSFGIS GANAHVVLEA
3210 3220 3230 3240 3250
GPPAAPAPLP AADPVPEDVV WPVSARTPDG VRDVAGRLTA LTAPAAAIGH
3260 3270 3280 3290 3300
SLATTRTAMR HRAVVPARDA EAFARGEEVP GVVRGTADVT DTRAVFVFPG
3310 3320 3330 3340 3350
QGSQWDGMGA ELLATEPVFA RRLGECAEAL APYTGWDLLD VIARRPGAPE
3360 3370 3380 3390 3400
LDRVDVVQPA SFAMMVALAE LWRAHGVAPA AVVGHSQGEV AAACVAGVLT
3410 3420 3430 3440 3450
LDDAAKVVAL RSRLVATERA GHGGMVSVPP ADFDAAAWAG RLEVAAVNGP
3460 3470 3480 3490 3500
ASIVVAGAAD AVEELLAATP HARRIAVDYA SHTAHVESIR GALLDALADL
3510 3520 3530 3540 3550
TPGAPEIPFF STVDEAWLDR PADAAYWYDN VRCPVRFGAA AARLAELGHR
3560 3570 3580 3590 3600
VFVEASPHPV LTTALADTLA GHPNTAVTGT LRRGDGGARR FTRSLAELWV
3610 3620 3630 3640 3650
RGVPVSWPFG ELRGVPLPTY PFRRDRYWVD AEPAGTSGHP LLGSLVERAD
3660 3670 3680 3690 3700
GEGAFATALF SVRRQPWLAD HEVDGRIIVP GSALVELLAE AGARLGTPTI
3710 3720 3730 3740 3750
AELTIVAPVV VDEERDTEIQ LTVATEVSGR RAVRLHSRTG AGPWTVGATG
3760 3770 3780 3790 3800
ALSADTRDPE PVEWPPADAE PVDLTGFYDT LPISYGPAFR AMTAMWAGQG
3810 3820 3830 3840 3850
RAYASVRLGE QLTDARYGLH PVLLDAAVHA LGTLFADPER RRLAFSWSGV
3860 3870 3880 3890 3900
RIHARAATTQ RVLLERADGD TIRILATDEH GAPVLDVDGL TVRAAEPGTE
3910 3920 3930 3940 3950
ALFEVAWVSV PASPVPGWTH LADVPEGDVL EGDAGEGDVG ESDPPPVVVL
3960 3970 3980 3990 4000
AVEPGDPDSS PGVRARELGR DLLATVRTWL AAPRWAESRI VVVTRTGDPA
4010 4020 4030 4040 4050
QEALGGLVRT AGTEHPGRVG RIEADEITPA TVEAGLAAGD ESHVRVTDGT
4060 4070 4080 4090 4100
VRAARLRRVT ASTGASPLSG GTVLVTGGTG GLGRLLVDHL LTAHEAAEVV
4110 4120 4130 4140 4150
VASRGGRPDG APADDRVRYV AADVTDRDEL AALVDGVAER LCAVVHMAGI
4160 4170 4180 4190 4200
VDDAVVATMR PQQWDAVLRV KADVAWQLHE LTRDLELAAF VLYSSISATF
4210 4220 4230 4240 4250
GGAGQANYAT GNAFLDALAR HRRDQGLPAV SLAWGLWDEA DGMGGRLAAT
4260 4270 4280 4290 4300
DLTRIARGGM IPMTAEQGLE LFDAALHSDR AALVPVRLDL AAVAASDQVP
4310 4320 4330 4340 4350
PILRDLVPNA RRAAAPTAAR DMLELVRTSA ALVLGHRDAH AVEPTRAFKE
4360 4370 4380 4390 4400
VGFDSLTGVE LRNRLADATG LTLPATLVFD HPTAQALAAH LDELAGARTA
4410 4420 4430 4440 4450
TRRRTPAPAR RHDEPLAIVG MACRLPGGVA SPDDLWRLLE SGGDGITAFP
4460 4470 4480 4490 4500
ADRGWDVDAL YDPDPEHSGT STVRHGGFLT GAGDFDAGFF GISPREALAM
4510 4520 4530 4540 4550
DPQQRVVLET SWEALEHAGI DPHTLRGTET GVFMGGYFYG YGSGADRGDF
4560 4570 4580 4590 4600
GATSTQTSVL SGRLSYFYCL EGPAVTVDTA CSSSLVALHQ AGQSLRTGEC
4610 4620 4630 4640 4650
SLALVGGVTV MASPSGFVDF SQQRGLAPDG RCKAFAEAAD GTAFAEGSGV
4660 4670 4680 4690 4700
LVVERLSDAE RHGHRVLAVV RGSAVNQDGA SNGLSAPNGP SQERVIRQAL
4710 4720 4730 4740 4750
ANAGLQPSDV DAIEAHGTGT RLGDPIEATA LLATYGQDRA TPLLLGSLKS
4760 4770 4780 4790 4800
NIGHTQAAAG VAGIIKMVLA MRHGTLPPTL HVDTPSSHVD WSAGTVELLT
4810 4820 4830 4840 4850
DARTWPETGR PHRAAVSSFG VSGTNAHVII ESHPRPTPAP DTGSSTHPVP
4860 4870 4880 4890 4900
LLISARTPEA LDEHTTRVRA FLDAEGEDER AVASALLTRT AFTHRAALIG
4910 4920 4930 4940 4950
TDLITGTAEP DRRLVWLFSG QGSQRPGMGD ELAAAYDVFA RTRRDVLDAL
4960 4970 4980 4990 5000
QVPAGLDVHD TGYAQPAVFA LQVALSAQLD AWGVRPDVLV GHSIGELAAA
5010 5020 5030 5040 5050
YVAGVWSLDD ATELVSARAR LMQALPPGGA MAAVSASERD ALPLLCEGVE
5060 5070 5080 5090 5100
IAAVNGPASI VLSGDEDAVL DVAARLGRFT RLRTSHAFHS ARMEPMLDEF
5110 5120 5130 5140 5150
RDVAERLTYH EPKLPMAAGA DCATPEYWVR QVRDTVRFAE QVAAYDGAAL
5160 5170 5180 5190 5200
LEIGPDRNLA RLVDGIPVLH GEDEARSAMT ALARLHTGGV AVDWPEVIGA
5210 5220 5230 5240 5250
APTDLPHLPT YPFERTRYWL GSRAAGDAAP AGQLPVAHPV LTAAVMVPGT
5260 5270 5280 5290 5300
GDLVLTGRVE ATDPLATRVR HPGAARAVLL DLRSRRATKR AAAPWRRSPW
5310 5320 5330 5340 5350
TPRSALPQSG GLALSVTVAA PGEDGRRAVA VHARPGTGEW TEHATGILAR
5360 5370 5380 5390 5400
VARVASAVPE TPSPWPPATA RPFDVGELAD RLARAGHTDG PALPRPRAAW
5410 5420 5430 5440 5450
ADDDAVHAEV ALADEQHADA ERYGLHPALL GAALALAGEG ADLPSAFDDV
5460 5470 5480 5490 5500
RVHATGATTV RVAVTATGIH LADETGSPVA TVGAVRRRPL TVEGAVPGLL
5510 5520 5530 5540 5550
RPDLAEIAEL PPTTATTGGL DDPVVPDVVI LPAHGTGGGP LGETRDLGAR
5560 5570 5580 5590 5600
VLAALRSFLT DDRYADAVLA VHTGPGLAPA AAAGLVRTAQ AEHPRRIVVV
5610 5620 5630 5640 5650
DAEPDTAAPL LAAAAGLGEP QVVLREGRAY ARRLTPAVPS GDAPELDPDG
5660 5670 5680 5690 5700
TVLITGGSGT LAGIVARHLV GHYGVRRLLM LSRGGTASDV PGAEVTAVAC
5710 5720 5730 5740 5750
DIADRDELAS ALAGIDPAHP LTAVVHTAAV IDDGVLTALT PERLDTVLRP
5760 5770 5780 5790 5800
KADGAWHLHE LTKDQDLAAL CSTPRPPECS ATRDRATTPR RTLLDELAEQ
5810 5820 5830 5840 5850
RRAGGLPALS VAWGLWEPES GLTAGAGDRM RRDGVTALST ERGLALLDAA
5860 5870 5880 5890 5900
LRSPEAALVA ADPGGLGSSA LLRAPHRGPR RRAAGASALA DRIAGLSAAD
5910 5920 5930 5940 5950
AEKAALAVVR ECAAAVLGHE GPARIEATAT FKELGVDSLT AVRLRNAFTE
5960 5970 5980 5990 6000
ATDVRLPATA VFDFPTPQAV AAKLTAALTG RVPARARATK AVGGHDEPLA
6010 6020 6030 6040 6050
IVGMACRLPG GVASPDDLWR LLESGGDGIT AFPADRGWDV DALYDPDPEH
6060 6070 6080 6090 6100
SGTSTVRHGG FLTGAGDFDA GFFGISPREA LAMDPQQRVV LETSWEALEQ
6110 6120 6130 6140 6150
AGIVPGTLRG SDTGVFMGAF SDGYGLGTDL GGFGATGTQT SVLSGRLSYF
6160 6170 6180 6190 6200
YGLEGPAVTV DTACSSSLVA LHQAGQSLRT GECSLALVGG VTVMASPGGF
6210 6220 6230 6240 6250
VEFSQQRGLA PDGRCKAFAE AADGTAFAEG SGVLVVERLS DAERHGHRVL
6260 6270 6280 6290 6300
AVVRGSAVNQ DGASNGLSAP NGPSQERVIR QALANAGLQP SDVDAIEAHG
6310 6320 6330 6340 6350
TGTRLGDPIE ATALLATYGQ HRTTPLLLGS LKSNIGHTQA AAGVAGIIKM
6360 6370 6380 6390 6400
VLAMRHGTLP PTLHVDTPSS HVDWTTGDVE LLTQPRPWPQ TNRPHRAGIS
6410 6420 6430 6440 6450
FGVSGTNAHV IIEAHVAAEP PALNSPGPDS PVAEPGASLF ATERTPLPVS
6460 6470 6480 6490 6500
ARTSEAVDGQ VQRLREHLAA HPRDDPRAVA AALLATRTDF PHRAVLLGDD
6510 6520 6530 6540 6550
VVTGTALTAP RTVFVFPGQG SQWLGMGREL MAESPVFAAR MRQCADALAE
6560 6570 6580 6590 6600
HTGRDLIAML DDPAVKSRVD VVHPVCWAVM VSLAAVWEAA GVRPDAVVGH
6610 6620 6630 6640 6650
SQGEIAAACV AGAISLEDGA RLVALRSALL VRELAGRGAM GSIAFAAAAR
6660 6670 6680 6690 6700
IDGVWVAGRN GTATTIVSGR PDAVETLIAD YEARGVWVTR LVVDCPTHTP
6710 6720 6730 6740 6750
FVDPLYDELQ RIVAATTSRA PEIPWFSTAD ERWIDAPLDD EYWFRNMRNP
6760 6770 6780 6790 6800
VGFAAAVAAA REPGDTVFIE VSAHPVLLPA INGTTVGTLR RGGGADRVLD
6810 6820 6830 6840 6850
SLAKAHTVGV AVDWSTVVAA TGAADDAASV TAHDTGTAHD LPTYAFHHER
6860 6870 6880 6890 6900
YWIEPATGTD ASGLGLDAVD HPLLAASVAL PDSDEVLLTG RLSLATHPWL
6910 6920 6930 6940 6950
AGHTVDGEVL LPGPVFVELA GRGADEARCD LLDELVIETP LALPATGAVQ
6960 6970 6980 6990 7000
VRVTVAAADD AGRRAVRIHA RAHGGRTWTR HASGIAAIAT TESATADGPW
7010 7020 7030 7040 7050
PPARAERIDI ADFYRRLDEA RTSSAPSSGM SAAWSHGDTL FAEVALDGTL
7060 7070 7080 7090 7100
ARDAARYTLH PALLVTALQA GSLAAGSEDA GVRLPFAFTG VRVHSSGATK
7110 7120 7130 7140 7150
ARVTFAAGDG GARVHIADEL GQPVAEIGSF VTRPLAEADR GGDVRLYRRT
7160 7170 7180 7190 7200
WTGVRAPAAP GTTAVRYADL GDGATSDATS PDAASPDVVL MRASDPAEVR
7210 7220 7230 7240 7250
AALDDPRTAD ATLVVSAEAG SVAGAVAALL DAAEPGRLVL VQTADTVTPR
7260 7270 7280 7290 7300
RAAALARLDE PHLRLTGGRL EAPRLVPAPT TTTAAPYGDV VLLDGGSEEL
7310 7320 7330 7340 7350
ARRLGEHGAE VIHHKPGKLP ETPVSAVVHA HGAADSPWEL HRLTRDLPLT
7360 7370 7380 7390 7400
AFVLLVPPGE AAGPWEALAE LRRTEGLPAV AFTATEDRQT DLLDVACATG
7410 7420 7430 7440 7450
EAVVVATAPP RRGDPSPLWR PVQRPARRSA SDGGSLLERL PDLSPKDQEQ
7460 7470 7480 7490 7500
VLLDVVRDTA ATLLGHADAR AVTATTAFKD LGVDSLTALG LRDRLAEALG
7510 7520 7530 7540 7550
IPLPATLVFD YPAAGALSRH LLTLLAPDGN GTPVGGEPPA QVSVGAPATD
7560 7570
SEVASPDDEL IDDMDADALI AHVLKG
Length:7,576
Mass (Da):790,138
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49765AB9EE66DD96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF082100 Genomic DNA Translation: AAC68815.1

Protein sequence database of the Protein Information Resource

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PIRi
T17428

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ag:AAC68815

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082100 Genomic DNA Translation: AAC68815.1
PIRiT17428

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGiag:AAC68815

Phylogenomic databases

KOiK16375

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.10.129.110, 4 hits
3.40.366.10, 4 hits
3.40.47.10, 4 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR013154 ADH_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR011032 GroES-like_sf
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR042104 PKS_dehydratase_sf
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 4 hits
PF08240 ADH_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PF16197 KAsynt_C_assoc, 4 hits
PF00109 ketoacyl-synt, 4 hits
PF02801 Ketoacyl-synt_C, 4 hits
PF08659 KR, 3 hits
PF00550 PP-binding, 5 hits
PF14765 PS-DH, 4 hits
SMARTiView protein in SMART
SM00827 PKS_AT, 4 hits
SM00826 PKS_DH, 4 hits
SM00829 PKS_ER, 1 hit
SM00825 PKS_KS, 4 hits
SM00823 PKS_PP, 5 hits
SUPFAMiSSF47336 SSF47336, 5 hits
SSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 8 hits
SSF52151 SSF52151, 4 hits
SSF53901 SSF53901, 4 hits
SSF55048 SSF55048, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 4 hits
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ZGA4_9ACTN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZGA4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: December 11, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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