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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhB

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Thiamine pyrophosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-265-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:RP262
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622271 – 326Pyruvate dehydrogenase E1 component subunit betaAdd BLAST326

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi272947.RP262

Structurei

3D structure databases

ProteinModelPortaliQ9ZDR3
SMRiQ9ZDR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CPP Bacteria
COG0022 LUCA
HOGENOMiHOG000281450
KOiK00162
OMAiSRMRHHC

Family and domain databases

Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR027110 PDHB
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005475 Transketolase-like_Pyr-bd
IPR033248 Transketolase_C
PANTHERiPTHR11624:SF94 PTHR11624:SF94, 1 hit
PfamiView protein in Pfam
PF02779 Transket_pyr, 1 hit
PF02780 Transketolase_C, 1 hit
SMARTiView protein in SMART
SM00861 Transket_pyr, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
SSF52922 SSF52922, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZDR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQITVREALR DAMQEEMLRD EKVFVIGEEV AEYQGAYKVT QGLLEQFGSK
60 70 80 90 100
RVIDTPITEY GFAGLAVGAA FAGLRPIVEF MTFNFAMQAF DHIVNSAAKT
110 120 130 140 150
HYMSGGQVKC PIVFRGPNGA ASRVAAQHSQ NYTACYSHIP GLKVVAPYSA
160 170 180 190 200
EDHKGLMLTA IRDDNPVIFL ENEILYGHSF DVPDIIEPIP FSKAKILKEG
210 220 230 240 250
SNVTIVTFSI QVKLALDVVN ILQNDNIDCE LIDLRTIKPL DTDSIIESVK
260 270 280 290 300
KTNRLVIVEE GWFFAGVGAS IASIVMKEAF DYLDAPIEIV SGKDVPLPYA
310 320
VNLEKLAMPS ANDLIEAVKK VCYYSI
Length:326
Mass (Da):35,917
Last modified:May 1, 1999 - v1
Checksum:i12A50A7ABBB28A46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ235271 Genomic DNA Translation: CAA14724.1
PIRiB71681
RefSeqiNP_220647.1, NC_000963.1
WP_004596097.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14724; CAA14724; CAA14724
GeneIDi883167
KEGGirpr:RP262
PATRICifig|272947.5.peg.269

Similar proteinsi

Entry informationi

Entry nameiODPB_RICPR
AccessioniPrimary (citable) accession number: Q9ZDR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names

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