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Entry version 125 (02 Dec 2020)
Sequence version 1 (01 May 1999)
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Protein

Multifunctional fusion protein

Gene

secF

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationUniRule annotationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Protein translocase subunit SecDUniRule annotation
Protein-export membrane protein SecFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:secFUniRule annotation
Synonyms:secDUniRule annotation
Ordered Locus Names:SCO6160Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri100226 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001973 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei296 – 316HelicalUniRule annotationAdd BLAST21
Transmembranei323 – 343HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 368HelicalUniRule annotationAdd BLAST20
Transmembranei389 – 415HelicalUniRule annotationAdd BLAST27
Transmembranei427 – 450HelicalUniRule annotationAdd BLAST24
Transmembranei488 – 508HelicalUniRule annotationAdd BLAST21
Transmembranei601 – 618HelicalUniRule annotationAdd BLAST18
Transmembranei623 – 646HelicalUniRule annotationAdd BLAST24
Transmembranei652 – 673HelicalUniRule annotationAdd BLAST22
Transmembranei704 – 722HelicalUniRule annotationAdd BLAST19
Transmembranei728 – 752HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotationARBA annotation, Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

UniRule annotation

Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
100226.SCO6160

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SecD/SecF family. SecD subfamily.UniRule annotation
Belongs to the SecD/SecF family. SecF subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0341, Bacteria
COG0342, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007894_3_0_11

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9ZBS8

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTVNTGM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9ZBS8

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac

The PANTHER Classification System

More...
PANTHERi
PTHR30081, PTHR30081, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07549, Sec_GG, 2 hits
PF02355, SecD_SecF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01755, SECFTRNLCASE

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00916, 2A0604s01, 1 hit
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9ZBS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRSRPPSRS RSRTRSRSLN VRALVALAVM AGAVAIALTM PVRLGLDLRG
60 70 80 90 100
GTQIVLETKS TETTKADREA TDRTVEVLRG RIDALGVAEP TIVRSGENRV
110 120 130 140 150
VVELPGVQDP KKAADVLGRT AQLTVHSVLG AAEKPADATE GRTETAEDGE
160 170 180 190 200
RVLPDESGQS LRLKAATLTG QDVKGADARF DQQNGAGWTV TVDFKDSGSD
210 220 230 240 250
RWAQVTGEAA CNPAGDPTRR VAIVLDDKII SSPQVDPSVS CGAGITGGST
260 270 280 290 300
QITGSFDDAE ARELALLIKG GALPVPVETI EQRTIGATLG DEAIDAGAWA
310 320 330 340 350
AVIGTALTAL FIIVVYRLMG ALATVALLCY GLISYAALAA VGATLTLPGL
360 370 380 390 400
AGFVLAIGMA VDANVLVFER AREEQAARTR PSTRSALTAG FRSAFSAIAD
410 420 430 440 450
SNITTLIAAA LLFFLASGPV KGFGVTLGIG VLASMVSALV ITRVLAEFAA
460 470 480 490 500
SRPAVFRRPR ITGISSTGPV RDALLRRDPF LMRRPRRWLA ASLIVLVVAG
510 520 530 540 550
SGILVRGLNF GIEFTGGRLI EYSTATQVDP DRARDALADA GFPRAVVQSS
560 570 580 590 600
GDGDLTVRTE ELTDTEAATV TKAVAELGGE TEKVRDELIG PSLGEELRRD
610 620 630 640 650
ALIALGLALA AQLAYLAVRF RLLFGTAAVG ALAHDVVILV GVFAWLGKPI
660 670 680 690 700
DGVFLAALLT VIGYSVNDSV VLFDRIRELL GKERKAPFDR LTNDAILQTL
710 720 730 740 750
PRTVNTGMGA VLILASLAIL ADDSLTDFAL ALLIGVGVGT YSSVFTASPL
760 770 780 790
AIELHNRDTG SRPGRRRGGR TRATGKSEKP GKQVPTSRTE RQEVR
Length:795
Mass (Da):83,542
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38403390078C5BF5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL939126 Genomic DNA Translation: CAA22394.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T34673

NCBI Reference Sequences

More...
RefSeqi
NP_630265.1, NC_003888.3
WP_011030698.1, NZ_VNID01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAA22394; CAA22394; CAA22394

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1101601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sco:SCO6160

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|100226.15.peg.6268

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939126 Genomic DNA Translation: CAA22394.1
PIRiT34673
RefSeqiNP_630265.1, NC_003888.3
WP_011030698.1, NZ_VNID01000009.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi100226.SCO6160

Genome annotation databases

EnsemblBacteriaiCAA22394; CAA22394; CAA22394
GeneIDi1101601
KEGGisco:SCO6160
PATRICifig|100226.15.peg.6268

Phylogenomic databases

eggNOGiCOG0341, Bacteria
COG0342, Bacteria
HOGENOMiCLU_007894_3_0_11
InParanoidiQ9ZBS8
OMAiRTVNTGM
PhylomeDBiQ9ZBS8

Family and domain databases

HAMAPiMF_01463_B, SecD_B, 1 hit
MF_01464_B, SecF_B, 1 hit
InterProiView protein in InterPro
IPR005791, SecD
IPR022813, SecD/SecF_arch_bac
IPR022645, SecD/SecF_bac
IPR022646, SecD/SecF_CS
IPR005665, SecF_bac
PANTHERiPTHR30081, PTHR30081, 2 hits
PfamiView protein in Pfam
PF07549, Sec_GG, 2 hits
PF02355, SecD_SecF, 2 hits
PRINTSiPR01755, SECFTRNLCASE
TIGRFAMsiTIGR00916, 2A0604s01, 1 hit
TIGR00966, 3a0501s07, 1 hit
TIGR01129, secD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9ZBS8_STRCO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9ZBS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: December 2, 2020
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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