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Protein

Glutaconyl-CoA decarboxylase subunit gamma

Gene

gcdC

Organism
Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Biotin carrier subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).

Catalytic activityi

4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2.

Cofactori

Pathwayi: L-glutamate degradation via hydroxyglutarate pathway

This protein is involved in step 5 of the subpathway that synthesizes crotonoyl-CoA from L-glutamate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Glutaconate CoA-transferase subunit B (gctB), Glutaconate CoA-transferase subunit A (gctA)
  4. (R)-2-hydroxyglutaryl-CoA dehydratase, subunit beta (hgdB), (R)-2-hydroxyglutaryl-CoA dehydratase activating ATPase (hgdC), (R)-2-hydroxyglutaryl-CoA dehydratase, subunit alpha (hgdA)
  5. Glutaconyl-CoA decarboxylase subunit delta (gcdD), Glutaconyl-CoA decarboxylase subunit gamma (gcdC), Glutaconyl-CoA decarboxylase subunit alpha (gcdA), Glutaconyl-CoA decarboxylase subunit beta (gcdB)
This subpathway is part of the pathway L-glutamate degradation via hydroxyglutarate pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes crotonoyl-CoA from L-glutamate, the pathway L-glutamate degradation via hydroxyglutarate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processIon transport, Sodium transport, Transport
LigandBiotin, Sodium

Enzyme and pathway databases

BioCyciAFER591001:G1GH7-1898-MONOMER
MetaCyc:MONOMER-1056
SABIO-RKiQ9ZAA7
UniPathwayi
UPA00533;UER00688

Protein family/group databases

TCDBi3.B.1.1.3 the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaconyl-CoA decarboxylase subunit gamma (EC:4.1.1.70)
Alternative name(s):
Biotin carrier
Gene namesi
Name:gcdC
Ordered Locus Names:Acfer_1835
OrganismiAcidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
Taxonomic identifieri591001 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesAcidaminococcalesAcidaminococcaceaeAcidaminococcus
Proteomesi
  • UP000001902 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001468391 – 145Glutaconyl-CoA decarboxylase subunit gammaAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Interactioni

Subunit structurei

Heterooctamer consisting of two alpha, two beta, two gamma and two delta subunits.

Protein-protein interaction databases

STRINGi591001.Acfer_1835

Structurei

3D structure databases

ProteinModelPortaliQ9ZAA7
SMRiQ9ZAA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 145Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 75Ala-richAdd BLAST53

Phylogenomic databases

eggNOGiENOG4105PV1 Bacteria
COG0511 LUCA
HOGENOMiHOG000008877
KOiK01615
OMAiDQVTENQ
OrthoDBiPOG091H05PV

Family and domain databases

InterProiView protein in InterPro
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ZAA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKFNVNVNG TVYTVEVEEV GGAVTAAPAA PAAPAAAPAA APVAAAPAAA
60 70 80 90 100
PAPAPAAAPA AAPAPAAKPA AAAPAGSVTV SAPMPGKILS VNVKPGDKVE
110 120 130 140
AGDVLLILEA MKMQNEIMAP EDGTVSEVRV NAGDTVATGD VMVIL
Length:145
Mass (Da):13,908
Last modified:May 1, 1999 - v1
Checksum:i4546006D4F2F4C6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030576 Genomic DNA Translation: AAC69172.1
CP001859 Genomic DNA Translation: ADB48189.1
RefSeqiWP_012939172.1, NC_013740.1

Genome annotation databases

EnsemblBacteriaiADB48189; ADB48189; Acfer_1835
KEGGiafn:Acfer_1835

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030576 Genomic DNA Translation: AAC69172.1
CP001859 Genomic DNA Translation: ADB48189.1
RefSeqiWP_012939172.1, NC_013740.1

3D structure databases

ProteinModelPortaliQ9ZAA7
SMRiQ9ZAA7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi591001.Acfer_1835

Protein family/group databases

TCDBi3.B.1.1.3 the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB48189; ADB48189; Acfer_1835
KEGGiafn:Acfer_1835

Phylogenomic databases

eggNOGiENOG4105PV1 Bacteria
COG0511 LUCA
HOGENOMiHOG000008877
KOiK01615
OMAiDQVTENQ
OrthoDBiPOG091H05PV

Enzyme and pathway databases

UniPathwayi
UPA00533;UER00688

BioCyciAFER591001:G1GH7-1898-MONOMER
MetaCyc:MONOMER-1056
SABIO-RKiQ9ZAA7

Family and domain databases

InterProiView protein in InterPro
IPR001882 Biotin_BS
IPR000089 Biotin_lipoyl
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF00364 Biotin_lipoyl, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
PROSITEiView protein in PROSITE
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCDC_ACIFV
AccessioniPrimary (citable) accession number: Q9ZAA7
Secondary accession number(s): D2RM87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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