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UniProtKB - Q9Z9U1 (DHSO_ALKHC)
Protein
Sorbitol dehydrogenase
Gene
gutB
Organism
Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans)
Status
Functioni
Polyol dehydrogenase that catalyzes the NAD+-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol), xylitol and L-iditol as substrates, leading to the C2-oxidized products D-fructose, D-xylulose and L-sorbose, respectively.
By similarityCatalytic activityi
Cofactori
Zn2+By similarityNote: Binds 1 Zn2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 39 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 60 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 61 | Zinc; catalyticBy similarity | 1 | |
Binding sitei | 146 | SubstrateBy similarity | 1 | |
Binding sitei | 174 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 200 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 262 – 264 | NADBy similarity | 3 |
GO - Molecular functioni
- D-xylulose reductase activity Source: UniProtKB-EC
- L-iditol 2-dehydrogenase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
BioCyci | BHAL272558:G1G3A-220-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Sorbitol dehydrogenaseBy similarity (EC:1.1.1.-By similarity)Short name: SDHBy similarity Alternative name(s): |
Gene namesi | Name:gutB Ordered Locus Names:BH0189 |
Organismi | Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) (Bacillus halodurans) |
Taxonomic identifieri | 272558 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Alkalihalobacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160824 | 1 – 343 | Sorbitol dehydrogenaseAdd BLAST | 343 |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 272558.10172801 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | COG1063, Bacteria |
HOGENOMi | CLU_026673_11_0_9 |
OMAi | GVFHNTP |
OrthoDBi | 972769at2 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z9U1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKALVKTQHG TGHFAVQEKP EPTPGKHQVK IKVKYTGVCG SDIHTYEGHY
60 70 80 90 100
PVAAPVTLGH EFSGEIVELG EGVTGFNVGD RVTSETTYSI CGKCSYCTSG
110 120 130 140 150
DYNLCSHRKG LGNQQDGSFA KYVIARQESL HHLPAGVDDR SAAMTEPLAC
160 170 180 190 200
THHAIAKTSI NKGDLVVVTG PGPIGLLAAQ VAKSHGGTVI ITGLSNDQVR
210 220 230 240 250
LKKAKEVGID YAIDTQEVDI KELVSELTDG YGADVVLECS GAVPAAKQGI
260 270 280 290 300
DLLRKKGQYA QVGLFAQPEI QFNFEKIIQK EISVVGSRSQ KPADWEPALS
310 320 330 340
LLNEKKVNAK TLVTHEYTIS EWDKAYHAIK SGEAIKVLLT PID
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011837 Genomic DNA Translation: BAA75341.1 BA000004 Genomic DNA Translation: BAB03908.1 |
PIRi | E83673 |
RefSeqi | WP_010896371.1, NC_002570.2 |
Genome annotation databases
EnsemblBacteriai | BAB03908; BAB03908; BAB03908 |
KEGGi | bha:BH0189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB011837 Genomic DNA Translation: BAA75341.1 BA000004 Genomic DNA Translation: BAB03908.1 |
PIRi | E83673 |
RefSeqi | WP_010896371.1, NC_002570.2 |
3D structure databases
AlphaFoldDBi | Q9Z9U1 |
SMRi | Q9Z9U1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272558.10172801 |
Genome annotation databases
EnsemblBacteriai | BAB03908; BAB03908; BAB03908 |
KEGGi | bha:BH0189 |
Phylogenomic databases
eggNOGi | COG1063, Bacteria |
HOGENOMi | CLU_026673_11_0_9 |
OMAi | GVFHNTP |
OrthoDBi | 972769at2 |
Enzyme and pathway databases
BioCyci | BHAL272558:G1G3A-220-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHSO_ALKHC | |
Accessioni | Q9Z9U1Primary (citable) accession number: Q9Z9U1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | May 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families