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Entry version 109 (26 Feb 2020)
Sequence version 1 (01 May 1999)
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Protein

4-hydroxybenzoate decarboxylase subunit C

Gene

CPn_0328

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible decarboxylation of 4-hydroxybenzoate.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The enzyme activity is enhanced by Mg2+, Fe2+, Mn2+ and Ca2+. No stimulation is observed with Cu2+ and Zn2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.21 mM for 4-hydroxybenzoate (at pH 7.5 and at 30 degrees Celsius)1 Publication
  1. Vmax=11.9 nmol/min/mg enzyme (at pH 7.5 and at 30 degrees Celsius)1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

Temperature dependencei

Optimum temperature is 30 degrees Celsius. It loses above 50% decarboxylase activity at 40 degrees Celsius for 5 minutes, and above 25% enzyme activity remains after incubation at 50 degrees Celius for 5 minutes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Lyase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CPNE115713:G1G19-329-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Z8L0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
4-hydroxybenzoate decarboxylase subunit C (EC:4.1.1.61)
Short name:
4-hydroxybenzoate DC
Short name:
HBDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:CPn_0328, CP_0429, CPj0328, CpB0338
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83558 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000583 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001573721 – 5844-hydroxybenzoate decarboxylase subunit CAdd BLAST584

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z8L0

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the decarboxylase complex composed of the subunits B and C (Potential). The subunit D usually found in other organisms seems to be absent.

Curated

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
115713.CPn_0328

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z8L0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UbiD family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4107RRM Bacteria
COG0043 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023348_4_1_0

KEGG Orthology (KO)

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KOi
K16239

Database of Orthologous Groups

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OrthoDBi
1012819at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022390 HBDC
IPR002830 UbiD

The PANTHER Classification System

More...
PANTHERi
PTHR30108 PTHR30108, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01977 UbiD, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03701 mena_SCO4490, 1 hit
TIGR00148 TIGR00148, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Z8L0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLRRHISL FRSQKQLIDV FAPVSPNLEL AEIHRRVIED QGPALLFHNV
60 70 80 90 100
IGSSFPVLTN LFGTKHRVDQ LFSQAPDNLI ARVAHLISST PKLSSLWKSR
110 120 130 140 150
DLLKRISSLG LKKARFRRFP FVSMSSVNLD HLPLLTSWPE DGGAFLTLPL
160 170 180 190 200
VYTESPTLTT PNLGMYRVQR FNQNTMGLHF QIQKGGGMHL YEAEQKKQNL
210 220 230 240 250
PVSVFLSGNP FLTLSAIAPL PENVSELLFA TFLQGAKLLY KKTNDHPHPL
260 270 280 290 300
LYDAEFILVG ESPAGKRRPE GPFGDHFGYY SLQHDFPEFH CHKIYHRKDA
310 320 330 340 350
IYPATVVGKP YQEDFYIGNK LQEYLSPLFP LVMPGVRRLK SYGESGFHAL
360 370 380 390 400
TAAVVKERYW RESLTTALRI LGEGQLSLTK FLMVTDQEVP LDRFSVVLET
410 420 430 440 450
ILERLQPDRD LIIFSETAND TLDYTGPSLN KGSKGIFMGI GKAIRDLPHG
460 470 480 490 500
YQGGKIHGVQ DIAPFCRGCL VLETSLEDRC IKSLLHHPDL KSWPLIILAD
510 520 530 540 550
NLRETIQSEK DFLWRTFTRC APANDLHALH SHFATHRPNY NFPFVIDALM
560 570 580
KPSYPKEVEV DPSTKQKVSE RWHAYFPNKE TFYI
Length:584
Mass (Da):66,507
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87F394EEE47748F5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18477.1
AE002161 Genomic DNA Translation: AAF38271.1
BA000008 Genomic DNA Translation: BAA98538.1
AE009440 Genomic DNA Translation: AAP98271.1

Protein sequence database of the Protein Information Resource

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PIRi
A72092
H86531

NCBI Reference Sequences

More...
RefSeqi
NP_224533.1, NC_000922.1
WP_010882976.1, NZ_LN847257.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAD18477; AAD18477; CPn_0328
AAF38271; AAF38271; CP_0429
AAP98271; AAP98271; CpB0338
BAA98538; BAA98538; BAA98538

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
894714

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cpa:CP_0429
cpj:CPj0328
cpn:CPn0328
cpt:CpB0338

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|115713.3.peg.364

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18477.1
AE002161 Genomic DNA Translation: AAF38271.1
BA000008 Genomic DNA Translation: BAA98538.1
AE009440 Genomic DNA Translation: AAP98271.1
PIRiA72092
H86531
RefSeqiNP_224533.1, NC_000922.1
WP_010882976.1, NZ_LN847257.1

3D structure databases

SMRiQ9Z8L0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi115713.CPn_0328

Proteomic databases

PRIDEiQ9Z8L0

Genome annotation databases

EnsemblBacteriaiAAD18477; AAD18477; CPn_0328
AAF38271; AAF38271; CP_0429
AAP98271; AAP98271; CpB0338
BAA98538; BAA98538; BAA98538
GeneIDi894714
KEGGicpa:CP_0429
cpj:CPj0328
cpn:CPn0328
cpt:CpB0338
PATRICifig|115713.3.peg.364

Phylogenomic databases

eggNOGiENOG4107RRM Bacteria
COG0043 LUCA
HOGENOMiCLU_023348_4_1_0
KOiK16239
OrthoDBi1012819at2

Enzyme and pathway databases

BioCyciCPNE115713:G1G19-329-MONOMER
SABIO-RKiQ9Z8L0

Family and domain databases

InterProiView protein in InterPro
IPR022390 HBDC
IPR002830 UbiD
PANTHERiPTHR30108 PTHR30108, 1 hit
PfamiView protein in Pfam
PF01977 UbiD, 1 hit
TIGRFAMsiTIGR03701 mena_SCO4490, 1 hit
TIGR00148 TIGR00148, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBSDC_CHLPN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z8L0
Secondary accession number(s): Q9JQJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: February 26, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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