Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf), Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd), 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102NADPBy similarity1
Binding sitei102SubstrateBy similarity1
Active sitei182Proton acceptorBy similarity1
Active sitei189Proton donorBy similarity1
Binding sitei190SubstrateBy similarity1
Binding sitei259Substrate; via amide nitrogenBy similarity1
Binding sitei286SubstrateBy similarity1
Binding sitei446Substrate; shared with dimeric partnerBy similarity1
Binding sitei452Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADPBy similarity6
Nucleotide bindingi32 – 34NADPBy similarity3
Nucleotide bindingi74 – 76NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:CPn_0360, CP_0398, CpB0369
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900321 – 4796-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST479

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi182082.CpB0369

Structurei

3D structure databases

ProteinModelPortaliQ9Z8I3
SMRiQ9Z8I3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 130Substrate bindingBy similarity3
Regioni185 – 186Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C7Q Bacteria
COG0362 LUCA
HOGENOMiHOG000255147
KOiK00033
OMAiNSHYPDS
OrthoDBiPOG091H01QF

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z8I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTNIGLIGL AVMGKNLVLN MIDHGFSVSV YNRTPEKTRD FLKEYPNHRE
60 70 80 90 100
LVGFESLEDF VNSLERPRKI MLMIQAGKPV DQSIHALLPF LEPGDVIIDG
110 120 130 140 150
GNSYFKDSER RCKELQEKGI LFLGVGISGG EEGARHGPSI MPGGNPEAWP
160 170 180 190 200
LVAPIFQSIA AKVQGRPCCS WVGTGGAGHY VKAVHNGIEY GDIQLICEAY
210 220 230 240 250
GILRDFLKLS ATAVATILKE WNTLELESYL IRIASEVLAL KDPEGIPVID
260 270 280 290 300
TILDVVGQKG TGKWTAIDAL NSGVPLSLII GAVLARFLSS WKEIREQAAR
310 320 330 340 350
NYPGTPLIFE MPHDPSVFIQ DVFHALYASK IISYAQGFML LGEASKEYNW
360 370 380 390 400
GLDLGEIALM WRGGCIIQSA FLDVIHKGFA ANPENTSLIF QEYFRGALRH
410 420 430 440 450
AEMGWRRTVV TAIGAGLPIP CLAAAITFYD GYRTASSSMS LAQGLRDYFG
460 470
AHTYERNDRP RGEFYHTDWV HTKTTERVK
Length:479
Mass (Da):52,939
Last modified:May 1, 1999 - v1
Checksum:i0FD301D3378E11F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18504.1
AE002161 Genomic DNA Translation: AAF38243.1
BA000008 Genomic DNA Translation: BAA98568.1
AE009440 Genomic DNA Translation: AAP98300.1
PIRiC72088
F86535
RefSeqiNP_224560.1, NC_000922.1
WP_010883003.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18504; AAD18504; CPn_0360
AAF38243; AAF38243; CP_0398
AAP98300; AAP98300; CpB0369
BAA98568; BAA98568; BAA98568
GeneIDi895135
KEGGicpa:CP_0398
cpj:gnd
cpn:CPn0360
cpt:CpB0369
PATRICifig|115713.3.peg.398

Similar proteinsi

Entry informationi

Entry namei6PGD_CHLPN
AccessioniPrimary (citable) accession number: Q9Z8I3
Secondary accession number(s): Q9JQC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health