Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumBy similarity1
Metal bindingi70MagnesiumBy similarity1
Metal bindingi145MagnesiumBy similarity1
Metal bindingi148MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:CPn_0621, CP_0126, CpB0647
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830881 – 168Crossover junction endodeoxyribonuclease RuvCAdd BLAST168

Proteomic databases

PRIDEiQ9Z7T3

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0647

Structurei

3D structure databases

ProteinModelPortaliQ9Z7T3
SMRiQ9Z7T3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.Curated

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012181
KOiK01159
OMAiGLTRCGI
OrthoDBiPOG091H0202

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z7T3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELIIGVDP GTIVAGYAII AVEQRYQLRP YSYGAIRLSS DMPLPMRYKT
60 70 80 90 100
LFEQLSGVLD DTQPNAMVLE TQFVNKNPQS TMKLAMARGI VLLAAAQRDI
110 120 130 140 150
LIFEYAPNVA KKAVVGKGHA SKRQVQVMVS KILNVPEVLH PSNEDIADAF
160
ALAICHTHVA RSPLCGVR
Length:168
Mass (Da):18,404
Last modified:May 1, 1999 - v1
Checksum:i3845FAC6DC0AFD1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18760.1
AE002161 Genomic DNA Translation: AAF38009.1
BA000008 Genomic DNA Translation: BAA98828.1
AE009440 Genomic DNA Translation: AAP98576.1
PIRiA72057
B86568
RefSeqiNP_224817.1, NC_000922.1
WP_010883259.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18760; AAD18760; CPn_0621
AAF38009; AAF38009; CP_0126
AAP98576; AAP98576; CpB0647
BAA98828; BAA98828; BAA98828
GeneIDi895409
KEGGicpa:CP_0126
cpj:ruvC
cpn:CPn0621
cpt:CpB0647
PATRICifig|115713.3.peg.691

Similar proteinsi

Entry informationi

Entry nameiRUVC_CHLPN
AccessioniPrimary (citable) accession number: Q9Z7T3
Secondary accession number(s): Q9JQH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again