UniProtKB - Q9Z7D1 (IXTPA_CHLPN)
Protein
dITP/XTP pyrophosphatase
Gene
CPn_0775
Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Functioni
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.UniRule annotation
Catalytic activityi
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 70 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 70 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 71 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 177 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- nucleoside-triphosphatase activity Source: InterPro
- nucleoside-triphosphate diphosphatase activity Source: UniProtKB-UniRule
- nucleotide binding Source: UniProtKB-KW
GO - Biological processi
- nucleotide metabolic process Source: UniProtKB-KW
- purine nucleoside triphosphate catabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase |
Biological process | Nucleotide metabolism |
Ligand | Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | CPNE115713:G1G19-782-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: dITP/XTP pyrophosphataseUniRule annotation (EC:3.6.1.66UniRule annotation)Alternative name(s): Non-canonical purine NTP pyrophosphataseUniRule annotation Non-standard purine NTP pyrophosphataseUniRule annotation Nucleoside-triphosphate diphosphataseUniRule annotation Nucleoside-triphosphate pyrophosphataseUniRule annotation Short name: NTPaseUniRule annotation |
Gene namesi | Ordered Locus Names:CPn_0775, CP_1097, CPj0775, CpB0802 |
Organismi | Chlamydia pneumoniae (Chlamydophila pneumoniae) |
Taxonomic identifieri | 83558 [NCBI] |
Taxonomic lineagei | Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000178150 | 1 – 206 | dITP/XTP pyrophosphataseAdd BLAST | 206 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 115713.CPn_0775 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 12 | Substrate bindingUniRule annotation | 6 | |
Regioni | 154 – 157 | Substrate bindingUniRule annotation | 4 | |
Regioni | 182 – 183 | Substrate bindingUniRule annotation | 2 |
Sequence similaritiesi
Belongs to the HAM1 NTPase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4108V82 Bacteria COG0127 LUCA |
HOGENOMi | HOG000293319 |
KOi | K02428 |
Family and domain databases
CDDi | cd00515 HAM1, 1 hit |
Gene3Di | 3.90.950.10, 1 hit |
HAMAPi | MF_01405 Non_canon_purine_NTPase, 1 hit |
InterProi | View protein in InterPro IPR020922 dITP/XTP_pyrophosphatase IPR002637 Ham1p-like IPR029001 ITPase-like_fam |
PANTHERi | PTHR11067 PTHR11067, 1 hit |
Pfami | View protein in Pfam PF01725 Ham1p_like, 1 hit |
SUPFAMi | SSF52972 SSF52972, 1 hit |
TIGRFAMsi | TIGR00042 TIGR00042, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Z7D1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIVIASSHG YKIRETKTFL KRLGDFDIFS LSDFPDYKLP QEQEDSITAN
60 70 80 90 100
ALTKGIHAAN HLGCWVIADD TMLRVPALNG LPGPLSANFA GVGAYDKDHR
110 120 130 140 150
KKLLDLMSSL ESLVDRSAYF ECCVVLVSPN QEIFKTYGIC EGYISHQEKG
160 170 180 190 200
SSGFGYDPIF VKYDYKQTFA ELSEDVKNQV SHRAKALQKL APHLQSLFEK
HLLTRD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | E → G in AAD18913 (PubMed:10192388).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001363 Genomic DNA Translation: AAD18913.1 AE002161 Genomic DNA Translation: AAF73731.1 BA000008 Genomic DNA Translation: BAA98983.1 AE009440 Genomic DNA Translation: AAP98732.1 |
PIRi | B72036 E86587 |
RefSeqi | NP_224970.1, NC_000922.1 WP_010892269.1, NZ_LN847221.1 |
Genome annotation databases
EnsemblBacteriai | AAD18913; AAD18913; CPn_0775 AAF73731; AAF73731; CP_1097 AAP98732; AAP98732; CpB0802 BAA98983; BAA98983; BAA98983 |
GeneIDi | 895062 |
KEGGi | cpa:CP_1097 cpj:yggV cpn:CPn0775 cpt:CpB0802 |
PATRICi | fig|115713.3.peg.852 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE001363 Genomic DNA Translation: AAD18913.1 AE002161 Genomic DNA Translation: AAF73731.1 BA000008 Genomic DNA Translation: BAA98983.1 AE009440 Genomic DNA Translation: AAP98732.1 |
PIRi | B72036 E86587 |
RefSeqi | NP_224970.1, NC_000922.1 WP_010892269.1, NZ_LN847221.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 115713.CPn_0775 |
Genome annotation databases
EnsemblBacteriai | AAD18913; AAD18913; CPn_0775 AAF73731; AAF73731; CP_1097 AAP98732; AAP98732; CpB0802 BAA98983; BAA98983; BAA98983 |
GeneIDi | 895062 |
KEGGi | cpa:CP_1097 cpj:yggV cpn:CPn0775 cpt:CpB0802 |
PATRICi | fig|115713.3.peg.852 |
Phylogenomic databases
eggNOGi | ENOG4108V82 Bacteria COG0127 LUCA |
HOGENOMi | HOG000293319 |
KOi | K02428 |
Enzyme and pathway databases
BioCyci | CPNE115713:G1G19-782-MONOMER |
Family and domain databases
CDDi | cd00515 HAM1, 1 hit |
Gene3Di | 3.90.950.10, 1 hit |
HAMAPi | MF_01405 Non_canon_purine_NTPase, 1 hit |
InterProi | View protein in InterPro IPR020922 dITP/XTP_pyrophosphatase IPR002637 Ham1p-like IPR029001 ITPase-like_fam |
PANTHERi | PTHR11067 PTHR11067, 1 hit |
Pfami | View protein in Pfam PF01725 Ham1p_like, 1 hit |
SUPFAMi | SSF52972 SSF52972, 1 hit |
TIGRFAMsi | TIGR00042 TIGR00042, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IXTPA_CHLPN | |
Accessioni | Q9Z7D1Primary (citable) accession number: Q9Z7D1 Secondary accession number(s): Q9JS41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2002 |
Last sequence update: | August 30, 2002 | |
Last modified: | May 8, 2019 | |
This is version 119 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteomeDocuments
- SIMILARITY comments
Index of protein domains and families