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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74SubstrateUniRule annotation1
Metal bindingi223ManganeseUniRule annotation1
Metal bindingi243Manganese; via tele nitrogenUniRule annotation1
Binding sitei265SubstrateUniRule annotation1
Active sitei267UniRule annotation1
Metal bindingi290ManganeseUniRule annotation1
Binding sitei381GTPUniRule annotation1
Binding sitei412GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi266 – 271GTPUniRule annotation6
Nucleotide bindingi506 – 509GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:CPn_0851, CP_1018, CpB0880
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001035981 – 600Phosphoenolpyruvate carboxykinase [GTP]Add BLAST600

Proteomic databases

PRIDEiQ9Z755

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi182082.CpB0880

Structurei

3D structure databases

ProteinModelPortaliQ9Z755
SMRiQ9Z755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni214 – 216Substrate bindingUniRule annotation3
Regioni379 – 381Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
HOGENOMiHOG000191700
KOiK01596
OMAiCWLALTD
OrthoDBiPOG091H0B4F

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWSTNIKHE GLKSWIDEVA KLTTPKDIRL CDGSDTEYDE LCTLMESTGT
60 70 80 90 100
MIRLNPEFHP NCFLVRSSAD DVARVEQFTF ICTSTEAEAG PTNNWRDPQE
110 120 130 140 150
MRRELHQLFR GCMQGRTLYI VPFCMGPLDS PFSIVGVELT DSPYVVCSMK
160 170 180 190 200
IMTRMGDDVL RSLGTSGKFL KCLHSVGKPL SPGEADVSWP CNPKSMRIVH
210 220 230 240 250
FQDDSSVMSF GSGYGGNALL GKKCVALRLA SYMAKSQGWL AEHMLIIGIT
260 270 280 290 300
NPEGKKKYFS ASFPSACGKT NLAMLMPKLP GWKIECIGDD IAWIRPGRDG
310 320 330 340 350
RLYAVNPEYG FFGVAPGTSE RTNPNALATC RSNSIFTNVA LTADGDVWWE
360 370 380 390 400
GLTEQPPEPL TDWLGKPWKP GGSPAAHPNS RFTAPLRQCP SLDPEWNSPQ
410 420 430 440 450
GVPLDAIIFG GRRSETIPLV YEALSWEHGV TIGAGMSSTT TAAIVGQLGK
460 470 480 490 500
LRHDPFAMLP FCGYNMAYYF QHWLSFAENR SLKLPKIFGV NWFRKNNQGE
510 520 530 540 550
FLWPGFSENL RVLEWIFQRT DGLEDIAERT PIGYLPNIQK FNLNGLNLDL
560 570 580 590 600
QTVQELFSVD AEGWLAEVEN IGEYLKIFGS DCPQQITDEL LRIKSELKEK
Length:600
Mass (Da):66,992
Last modified:May 1, 1999 - v1
Checksum:i79590DC1A0A9932A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD18989.1
AE002161 Genomic DNA Translation: AAF73723.1
BA000008 Genomic DNA Translation: BAA99059.1
AE009440 Genomic DNA Translation: AAP98809.1
PIRiA86597
E72027
RefSeqiNP_225046.1, NC_000922.1
WP_010883486.1, NZ_LN847257.1

Genome annotation databases

EnsemblBacteriaiAAD18989; AAD18989; CPn_0851
AAF73723; AAF73723; CP_1018
AAP98809; AAP98809; CpB0880
BAA99059; BAA99059; BAA99059
GeneIDi895150
KEGGicpa:CP_1018
cpj:pckA
cpn:CPn0851
cpt:CpB0880
PATRICifig|115713.3.peg.931

Similar proteinsi

Entry informationi

Entry nameiPCKG_CHLPN
AccessioniPrimary (citable) accession number: Q9Z755
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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