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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Chlamydia pneumoniae (Chlamydophila pneumoniae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:CPn_0900, CP_0966, CpB0932
OrganismiChlamydia pneumoniae (Chlamydophila pneumoniae)
Taxonomic identifieri83558 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000583 Componenti: Chromosome
  • UP000000801 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei91 – 111HelicalUniRule annotationAdd BLAST21
Transmembranei129 – 149HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei197 – 217HelicalUniRule annotationAdd BLAST21
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei327 – 347HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001088061 – 349Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST349

Interactioni

Protein-protein interaction databases

STRINGi182082.CpB0932

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPLIPMFLK QSLFFSLALT GMTTLVLTVS LGVPVMKWLK RKNYRDYIHK
60 70 80 90 100
EYCEKLEMLH KDKAEVPTGG GVLLFISLIA SLLVWLPWGK FSTWFFIILL
110 120 130 140 150
TCYAGLGWYD DRIKIKRKQG HGLKAKHKFM VQIAIAAFTL IALPYIYGST
160 170 180 190 200
EPLWTLKIPF MEGMLSLPFW LGKVFCLGLA LVAIIGTSNA VNLTDGLDGL
210 220 230 240 250
AAGTMSFAAL GFIFVALRSS TIPIAQDVAY VLAALVGACI GFLWYNGFPA
260 270 280 290 300
QLFMGDTGSL LLGGLLGSCA VMLRAECILV VIGGVFVAEA GSVILQVLSC
310 320 330 340
RLRKKRLFLC SPLHHHYEYQ GLPETKIVMR FWIFSFVCAG LGIAAVLWR
Length:349
Mass (Da):38,590
Last modified:January 11, 2001 - v2
Checksum:i6CAA9283C594A88B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30S → A in strain: CWL029 and TW-183. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001363 Genomic DNA Translation: AAD19038.1
AE002161 Genomic DNA Translation: AAF38746.1
BA000008 Genomic DNA Translation: BAA99108.1
AE009440 Genomic DNA Translation: AAP98861.1
PIRiA81519
B86603
G72021
RefSeqiNP_225095.1, NC_000922.1
WP_010892232.1, NZ_LN846995.1

Genome annotation databases

EnsemblBacteriaiAAD19038; AAD19038; CPn_0900
AAF38746; AAF38746; CP_0966
AAP98861; AAP98861; CpB0932
BAA99108; BAA99108; BAA99108
GeneIDi895314
KEGGicpa:CP_0966
cpj:mraY
cpn:CPn0900
cpt:CpB0932
PATRICifig|115713.3.peg.981

Similar proteinsi

Entry informationi

Entry nameiMRAY_CHLPN
AccessioniPrimary (citable) accession number: Q9Z706
Secondary accession number(s): Q9JS12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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