Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Z351 (KCNQ2_MOUSE)

Protein

Potassium voltage-gated channel subfamily KQT member 2

Gene

Kcnq2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.1 Publication

GO - Molecular functioni

  • ankyrin binding Source: MGI
  • calmodulin binding Source: MGI
  • delayed rectifier potassium channel activity Source: GO_Central
  • protein N-terminus binding Source: MGI
  • voltage-gated ion channel activity Source: MGI
  • voltage-gated potassium channel activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • potassium ion transmembrane transport Source: UniProtKB
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • transmission of nerve impulse Source: MGI
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 2Curated
Alternative name(s):
KQT-like 21 Publication
Potassium channel subunit alpha KvLQT2
Voltage-gated potassium channel subunit Kv7.2
Gene namesi
Name:Kcnq2Imported
Synonyms:Kqt21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1309503 Kcnq2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini113 – 122ExtracellularSequence analysis10
Transmembranei123 – 143Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini144 – 166CytoplasmicSequence analysisAdd BLAST23
Transmembranei167 – 187Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini188 – 197ExtracellularSequence analysis10
Transmembranei198 – 221Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST24
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini253 – 264ExtracellularSequence analysisAdd BLAST12
Intramembranei265 – 285Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini286 – 291ExtracellularSequence analysis6
Transmembranei292 – 312Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini313 – 759CytoplasmicSequence analysisAdd BLAST447

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice lacking Kcnq2 present no overt phenotype, but die a few hours after birth of pulmonary atelectasis which is not due to the status of epileptic seizures.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi345R → E: Loss of interaction with calmodulin. 1 Publication1
Mutagenesisi525K → E: Loss of interaction with calmodulin; when associated with E-526. 1 Publication1
Mutagenesisi526R → E: Loss of interaction with calmodulin; when associated with E-525. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540311 – 759Potassium voltage-gated channel subfamily KQT member 2Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52Phosphoserine; by PKABy similarity1
Modified residuei438PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei450PhosphoserineCombined sources1
Modified residuei479PhosphoserineBy similarity1
Modified residuei681PhosphoserineBy similarity1
Isoform 13 (identifier: Q9Z351-13)
Modified residuei813PhosphotyrosineCombined sources1
Isoform 12 (identifier: Q9Z351-12)
Modified residuei831PhosphotyrosineCombined sources1

Post-translational modificationi

KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region.By similarity
KCNQ2/KCNQ3 are ubiquitinated by NEDD4L. Ubiquitination leads to protein degradation. Degradation induced by NEDD4L is inhibited by USP36.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ9Z351

PTM databases

iPTMnetiQ9Z351
PhosphoSitePlusiQ9Z351

Expressioni

Tissue specificityi

Exclusively expressed in the brain. Expressed in every neuron-containing regions of the central nervous system examined, such as the cerebellum, cerebral cortex, occipital pole, substantia nigra, amygdala, caudate nucleus, hippocampus and thalamus. Also detected in the cochlea.

Developmental stagei

Detected at day 11, 15 and 17 of the embryonic development. Expression increases by a factor of 2.5 at 1 week after birth. Then the expression level remains stable until the adult stage. The mRNAs for shorter forms (isoforms 9, 10 and 11) are specifically expressed in an embryo on the 11th day after gestation.

Interactioni

Subunit structurei

Heterotetramer with KCNQ3; form the heterotetrameric M potassium channel (By similarity). Interacts with calmodulin; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:12223552). May associate with KCNE2 (By similarity). Interacts with IQCJ-SCHIP1 (PubMed:27979964).By similarity2 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi200918, 1 interactor
CORUMiQ9Z351
IntActiQ9Z351, 3 interactors

Chemistry databases

BindingDBiQ9Z351

Structurei

3D structure databases

ProteinModelPortaliQ9Z351
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni317 – 512Mediates interaction with calmodulinBy similarityAdd BLAST196

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 282Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG059014
InParanoidiQ9Z351
KOiK04927

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 2 hits
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL

Sequences (13+)i

Sequence statusi: Complete.

This entry describes 13 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 13 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z351-1) [UniParc]FASTAAdd to basket
Also known as: MKQT2.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR 
        60         70         80         90        100
GSVLSKPRTG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF 
       110        120        130        140        150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC 
       160        170        180        190        200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL 
       210        220        230        240        250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV 
       260        270        280        290        300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 
       310        320        330        340        350
GVSFFALPAG ILGSGFALKV QEQHRPKHFE KRRNPAAGLI QSAWRFYATN 
       360        370        380        390        400
LSRTDLHSTW QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ 
       410        420        430        440        450
PEPSPSQKVS LKDRVFSSPR GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS 
       460        470        480        490        500
KVPKSWSFGD RSRTRQAFRI KGAASRQNSE EASLPGEDIV EDNKSCNCEF 
       510        520        530        540        550
VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV IEQYSAGHLD 
       560        570        580        590        600
MLSRIKSLQS RIDMIVGPPP PSTPRDKKYP TKGPTAPSRE SPQYSPRVDH 
       610        620        630        640        650
IVGRGPTITD KDRTKGPAET ELPEDPSMMG RLGKVEKQVL SMEKKLDFLV 
       660        670        680        690        700
SIYTQRMGIP PAETEAYFGA KEPEPAPPYH SPEDSRDHAD KHGCIIKIVR 
       710        720        730        740        750
STSSTGQRNY AAPPAIPPAQ CPPSTSWQQS HQRHGTSPVG DHGSLVLRLE 

RSAGMMSCH
Length:759
Mass (Da):84,450
Last modified:May 1, 1999 - v1
Checksum:iC1D12DBFF3979D3F
GO
Isoform 2 (identifier: Q9Z351-2) [UniParc]FASTAAdd to basket
Also known as: MKQT2.2

The sequence of this isoform differs from the canonical sequence as follows:
     562-596: IDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSP → QEPLPVQSGHEQGPPGQNQAWHKGHQGLGD

Show »
Length:754
Mass (Da):83,871
Checksum:iE5B9E1302AD1BA3A
GO
Isoform 3 (identifier: Q9Z351-3) [UniParc]FASTAAdd to basket
Also known as: MKQT2.3

The sequence of this isoform differs from the canonical sequence as follows:
     407-418: Missing.

Show »
Length:747
Mass (Da):83,075
Checksum:i7766068E0E4660FA
GO
Isoform 4 (identifier: Q9Z351-4) [UniParc]FASTAAdd to basket
Also known as: MKQT2.4

The sequence of this isoform differs from the canonical sequence as follows:
     562-597: Missing.

Show »
Length:723
Mass (Da):80,519
Checksum:iB1A8D7BC05B0AAD2
GO
Isoform 5 (identifier: Q9Z351-5) [UniParc]FASTAAdd to basket
Also known as: MKQT2.5

The sequence of this isoform differs from the canonical sequence as follows:
     562-570: IDMIVGPPP → SCDWRGVLA
     571-759: Missing.

Show »
Length:570
Mass (Da):63,805
Checksum:iDB5DA2952C6B6D09
GO
Isoform 6 (identifier: Q9Z351-6) [UniParc]FASTAAdd to basket
Also known as: MKQT2.6

The sequence of this isoform differs from the canonical sequence as follows:
     562-623: IDMIVGPPPP...TKGPAETELP → QEPLPVQSGH...FLLCFHTVCF
     624-759: Missing.

Note: May be due to an intron retention.
Show »
Length:623
Mass (Da):69,734
Checksum:i8D2C7F4729A2BAB8
GO
Isoform 7 (identifier: Q9Z351-7) [UniParc]FASTAAdd to basket
Also known as: MKQT2.7

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     406-463: SQKVSLKDRV...KSWSFGDRSR → RSVPPASSRP...PGTPRVTSQL
     464-759: Missing.

Note: May be due to an intron retention.
Show »
Length:473
Mass (Da):52,651
Checksum:i3AFED94FA2262127
GO
Isoform 8 (identifier: Q9Z351-8) [UniParc]FASTAAdd to basket
Also known as: MKQT2.8

The sequence of this isoform differs from the canonical sequence as follows:
     406-463: SQKVSLKDRV...KSWSFGDRSR → RSVPPASSRP...PGTPRVTSQL
     464-759: Missing.

Note: May be due to an intron retention.
Show »
Length:463
Mass (Da):51,640
Checksum:i9E6F79DFE373028A
GO
Isoform 9 (identifier: Q9Z351-9) [UniParc]FASTAAdd to basket
Also known as: MKQT2.9

The sequence of this isoform differs from the canonical sequence as follows:
     342-349: SAWRFYAT → GQVRCAGH
     350-759: Missing.

Note: May be due to an intron retention.
Show »
Length:349
Mass (Da):38,652
Checksum:i034B50C777C54EC3
GO
Isoform 10 (identifier: Q9Z351-10) [UniParc]FASTAAdd to basket
Also known as: MKQT2.10

The sequence of this isoform differs from the canonical sequence as follows:
     342-347: SAWRFY → VSLSPC
     348-759: Missing.

Note: May be due to an intron retention.
Show »
Length:347
Mass (Da):38,430
Checksum:i93BEA660ADB9FA73
GO
Isoform 11 (identifier: Q9Z351-11) [UniParc]FASTAAdd to basket
Also known as: MKQT2.11

The sequence of this isoform differs from the canonical sequence as follows:
     310-338: GILGSGFALKVQEQHRPKHFEKRRNPAAG → VSPAHLPTLEMLGVLEAPHKAWPWPTCEL
     339-759: Missing.

Note: May be due to an intron retention.
Show »
Length:338
Mass (Da):37,483
Checksum:i82520B7C1C01FA2F
GO
Isoform 12 (identifier: Q9Z351-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     406-406: S → SKGRPCRGCLCGCCPGHSS
     562-597: Missing.
     747-759: LRLERSAGMMSCH → RIPPPPAHER...GDVAWAGPRK

Show »
Length:870
Mass (Da):95,720
Checksum:i59C6E7B4216708AA
GO
Isoform 13 (identifier: Q9Z351-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     372-372: Y → YSSQTQTYGAS
     571-606: Missing.
     747-759: LRLERSAGMMSCH → RIPPPPAHER...GDVAWAGPRK

Show »
Length:852
Mass (Da):93,906
Checksum:iBB27ADF9FA5BEE5D
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBV9B7ZBV9_MOUSE
Potassium voltage-gated channel sub...
Kcnq2 mCG_23080
870Annotation score:
B7ZBW1B7ZBW1_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
852Annotation score:
B7ZBV5B7ZBV5_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
570Annotation score:
B7ZBW2B7ZBW2_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
839Annotation score:
B7ZBV6B7ZBV6_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
754Annotation score:
B7ZBV7B7ZBV7_MOUSE
Potassium voltage-gated channel sub...
Kcnq2 mCG_23080
723Annotation score:
B7ZBV3B7ZBV3_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
726Annotation score:
B7ZBV4B7ZBV4_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
759Annotation score:
B7ZBV8B7ZBV8_MOUSE
Potassium voltage-gated channel sub...
Kcnq2 mCG_23080
747Annotation score:
A0A0G2JFQ2A0A0G2JFQ2_MOUSE
Potassium voltage-gated channel sub...
Kcnq2
842Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125A → P in BAA37161 (PubMed:9666519).Curated1
Sequence conflicti326P → Q in BAA37160 (PubMed:9666519).Curated1
Sequence conflicti326P → Q in BAA37165 (PubMed:9666519).Curated1
Sequence conflicti326P → Q in AAM09696 (PubMed:12223552).Curated1
Sequence conflicti600H → Q in AAM09696 (PubMed:12223552).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000991310 – 338GILGS…NPAAG → VSPAHLPTLEMLGVLEAPHK AWPWPTCEL in isoform 11. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_000992339 – 759Missing in isoform 11. 1 PublicationAdd BLAST421
Alternative sequenceiVSP_000993342 – 349SAWRFYAT → GQVRCAGH in isoform 9. 1 Publication8
Alternative sequenceiVSP_000995342 – 347SAWRFY → VSLSPC in isoform 10. 1 Publication6
Alternative sequenceiVSP_000996348 – 759Missing in isoform 10. 1 PublicationAdd BLAST412
Alternative sequenceiVSP_000994350 – 759Missing in isoform 9. 1 PublicationAdd BLAST410
Alternative sequenceiVSP_000997372Y → YSSQTQTYGAS in isoform 7, isoform 12 and isoform 13. 3 Publications1
Alternative sequenceiVSP_000998406 – 463SQKVS…GDRSR → RSVPPASSRPGVCCTHLALL SLCIHHVSWGRATMGPCVCF YVQQVTVCPGTPRVTSQL in isoform 7 and isoform 8. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_012365406S → SKGRPCRGCLCGCCPGHSS in isoform 12. 1 Publication1
Alternative sequenceiVSP_001000407 – 418Missing in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_000999464 – 759Missing in isoform 7 and isoform 8. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_001005562 – 623IDMIV…ETELP → QEPLPVQSGHEQGPPGQNQA WHKGHQGLGDRCAEQGQYQL WRSLPTLLASCCFLLCFHTV CF in isoform 6. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_001002562 – 597Missing in isoform 4 and isoform 12. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_001001562 – 596IDMIV…PQYSP → QEPLPVQSGHEQGPPGQNQA WHKGHQGLGD in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_001003562 – 570IDMIVGPPP → SCDWRGVLA in isoform 5. 1 Publication9
Alternative sequenceiVSP_001004571 – 759Missing in isoform 5. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_022637571 – 606Missing in isoform 13. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_001006624 – 759Missing in isoform 6. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_012366747 – 759LRLER…MMSCH → RIPPPPAHERSLSAYGGGNR ASTEFLRLEGTPACRPSEAA LRDSDTSISIPSVDHEELER SFSGFSISQSKENLDALGSC YAAVAPCAKVRPYIAEGESD TDSDLCTPCGPPPRSATGEG PFGDVAWAGPRK in isoform 12 and isoform 13. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000494 mRNA Translation: BAA37156.1
AB000495 mRNA Translation: BAA37157.1
AB000496 mRNA Translation: BAA37158.1
AB000497 mRNA Translation: BAA37159.1
AB000498 mRNA Translation: BAA37160.1
AB000499 mRNA Translation: BAA37161.1
AB000500 mRNA Translation: BAA37162.1
AB000501 mRNA Translation: BAA37163.1
AB000502 mRNA Translation: BAA37164.1
AB000503 mRNA Translation: BAA37165.1
AB000504 mRNA Translation: BAA37166.1
AF490773 mRNA Translation: AAM09696.1
AK139411 mRNA Translation: BAE24000.1
CCDSiCCDS17193.1 [Q9Z351-1]
CCDS17194.1 [Q9Z351-2]
CCDS17195.1 [Q9Z351-3]
CCDS17196.1 [Q9Z351-4]
CCDS17197.1 [Q9Z351-5]
CCDS17198.1 [Q9Z351-12]
RefSeqiNP_001006675.1, NM_001006674.2
NP_001289817.1, NM_001302888.1
NP_034741.2, NM_010611.3
UniGeneiMm.40615
Mm.440175

Genome annotation databases

GeneIDi16536
KEGGimmu:16536
UCSCiuc008olg.2 mouse [Q9Z351-11]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000494 mRNA Translation: BAA37156.1
AB000495 mRNA Translation: BAA37157.1
AB000496 mRNA Translation: BAA37158.1
AB000497 mRNA Translation: BAA37159.1
AB000498 mRNA Translation: BAA37160.1
AB000499 mRNA Translation: BAA37161.1
AB000500 mRNA Translation: BAA37162.1
AB000501 mRNA Translation: BAA37163.1
AB000502 mRNA Translation: BAA37164.1
AB000503 mRNA Translation: BAA37165.1
AB000504 mRNA Translation: BAA37166.1
AF490773 mRNA Translation: AAM09696.1
AK139411 mRNA Translation: BAE24000.1
CCDSiCCDS17193.1 [Q9Z351-1]
CCDS17194.1 [Q9Z351-2]
CCDS17195.1 [Q9Z351-3]
CCDS17196.1 [Q9Z351-4]
CCDS17197.1 [Q9Z351-5]
CCDS17198.1 [Q9Z351-12]
RefSeqiNP_001006675.1, NM_001006674.2
NP_001289817.1, NM_001302888.1
NP_034741.2, NM_010611.3
UniGeneiMm.40615
Mm.440175

3D structure databases

ProteinModelPortaliQ9Z351
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200918, 1 interactor
CORUMiQ9Z351
IntActiQ9Z351, 3 interactors

Chemistry databases

BindingDBiQ9Z351
ChEMBLiCHEMBL2985

PTM databases

iPTMnetiQ9Z351
PhosphoSitePlusiQ9Z351

Proteomic databases

PRIDEiQ9Z351

Protocols and materials databases

DNASUi16536
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16536
KEGGimmu:16536
UCSCiuc008olg.2 mouse [Q9Z351-11]

Organism-specific databases

CTDi3785
MGIiMGI:1309503 Kcnq2

Phylogenomic databases

HOVERGENiHBG059014
InParanoidiQ9Z351
KOiK04927

Miscellaneous databases

PROiPR:Q9Z351
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 2 hits
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL
ProtoNetiSearch...

Entry informationi

Entry nameiKCNQ2_MOUSE
AccessioniPrimary (citable) accession number: Q9Z351
Secondary accession number(s): Q3UTI0
, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again