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Entry version 166 (11 Dec 2019)
Sequence version 1 (01 May 1999)
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Protein

Partitioning defective 3 homolog

Gene

Pard3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:18550519). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). Targets the phosphatase PTEN to cell junctions (PubMed:18082612).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Differentiation
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-420029 Tight junction interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Partitioning defective 3 homolog
Short name:
PAR-3
Short name:
PARD-3
Alternative name(s):
Atypical PKC isotype-specific-interacting protein
Short name:
ASIP
Atypical PKC-specific-binding protein
Short name:
ASBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pard3
Synonyms:Par3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Rat genome database

More...
RGDi
620374 Pard3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi458K → E: Reduces binding to membranes containing phosphoinositol lipids by half. Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-546. 1 Publication1
Mutagenesisi491K → A: Slightly reduced binding to membranes containing phosphoinositol lipids. 1 Publication1
Mutagenesisi491K → E: Strongly reduced binding to membranes containing phosphoinositol lipids. 1 Publication1
Mutagenesisi504R → A: Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-506. 1 Publication1
Mutagenesisi504R → E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-506. 1 Publication1
Mutagenesisi506K → A: Slightly reduced binding to membranes containing phosphoinositol lipids; when associated with A-504. 1 Publication1
Mutagenesisi506K → E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-504. 1 Publication1
Mutagenesisi532R → A: Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-535. 1 Publication1
Mutagenesisi532R → E: Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-535. 1 Publication1
Mutagenesisi535K → A: Reduces binding to membranes containing phosphoinositol lipids by half; when associated with A-532. 1 Publication1
Mutagenesisi535K → E: Almost abolished binding to membranes containing phosphoinositol lipids; when associated with E-532. 1 Publication1
Mutagenesisi546R → E: Abolishes binding to membranes containing phosphoinositol lipids; when associated with E-458. 1 Publication1
Mutagenesisi827S → E: Abolishes binding to PKCI. 1 Publication1
Mutagenesisi829S → A: No detectable impact on binding to PKCI. 1 Publication1
Mutagenesisi829S → E: Abolishes binding to PKCI. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001850711 – 1337Partitioning defective 3 homologAdd BLAST1337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25PhosphoserineBy similarity1
Modified residuei91PhosphothreonineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei383PhosphoserineBy similarity1
Modified residuei489PhosphotyrosineBy similarity1
Modified residuei692PhosphoserineBy similarity1
Modified residuei695PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei728PhosphoserineBy similarity1
Modified residuei809PhosphoserineBy similarity1
Modified residuei827Phosphoserine2 Publications1
Modified residuei834N6-acetyllysineBy similarity1
Modified residuei837PhosphoserineBy similarity1
Modified residuei851N6-acetyllysineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei873PhosphoserineBy similarity1
Modified residuei885N6-acetyllysineBy similarity1
Modified residuei962Phosphoserine; by AURKABy similarity1
Modified residuei971PhosphoserineBy similarity1
Modified residuei973PhosphoserineBy similarity1
Modified residuei1046PhosphoserineBy similarity1
Modified residuei1331N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination.1 Publication
Phosphorylation at Ser-827 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1127 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-962 is required for the normal establishment of neuronal polarity (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z340

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z340

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z340

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z340

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is predominantly expressed in lung, glandular stomach, prostate, ovary and uterus. Isoform 1 is also expressed in brain, with a high expression in the cortex, hippocampus and in the striatum. Isoform 2 is predominantly expressed in intestinal epithelial cells, kidney and prostate.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000032437 Expressed in 10 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Z340 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z340 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, PATJ and PARD3/PAR3.

Interacts (via PDZ 1 domain) with PARD6A, PARD6B and F11R/JAM1.

Interacts with AURKA, AURKB and SIRT2 (By similarity).

Interacts with PRKCI.

Interacts with PRKCZ (Probable).

Part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1.

Interacts with LIMK2 and CDH5.

Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Directly interacts with TIAM1 and TIAM2.

Interacts with ECT2 and FBF1 (By similarity).

Interacts (via PDZ 3 domain) with PTEN (via C-terminus).

Interacts (via coiled-coil domain) with FRMD4A (By similarity).

Found in a complex with PARD3, CYTH1 and FRMD4A (By similarity).

Interacts with SAPCD2 (By similarity).

Interacts with PRKCA (By similarity).

By similarityCurated4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-349441,EBI-349441

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
249693, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Z340

Database of interacting proteins

More...
DIPi
DIP-33271N

Protein interaction database and analysis system

More...
IntActi
Q9Z340, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9Z340

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000048964

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Z340

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Z340

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini271 – 359PDZ 1PROSITE-ProRule annotationAdd BLAST89
Domaini461 – 546PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini590 – 677PDZ 3PROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni712 – 936Interaction with PRKCI and PRKCZ1 PublicationAdd BLAST225
Regioni935 – 1337Interaction with FRMD4ABy similarityAdd BLAST403

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1050 – 1082Sequence analysisAdd BLAST33
Coiled coili1149 – 1172Sequence analysisAdd BLAST24
Coiled coili1199 – 1222Sequence analysisAdd BLAST24
Coiled coili1278 – 1299Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi984 – 1042Lys-richAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains a conserved N-terminal oligomerization domain (NTD) that is involved in oligomerization and is essential for proper subapical membrane localization.
The second PDZ domain mediates interaction with membranes containing phosphoinositol lipids.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAR3 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3528 Eukaryota
ENOG4110362 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232109

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z340

KEGG Orthology (KO)

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KOi
K04237

Identification of Orthologs from Complete Genome Data

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OMAi
CNASSAN

Database of Orthologous Groups

More...
OrthoDBi
908238at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Z340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z340-1) [UniParc]FASTAAdd to basket
Also known as: 180 kDa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVTVCFGRT RVVVPCGDGR MKVFSLIQQA VTRYRKAVAK DPNYWIQVHR
60 70 80 90 100
LEHGDGGILD LDDILCDVAD DKDRLVAVFD EQDPHHGGDG TSASSTGTQS
110 120 130 140 150
PEIFGSELGT NNVSAFRPYQ TTSEIEVTPS VLRANMPLHV RRSSDPALTG
160 170 180 190 200
LSTSVSDNNF SSEEPSRKNP TRWSTTAGFL KQNTTGSPKT CDRKKDENYR
210 220 230 240 250
SLPRDPSSWS NQFQRDNARS SLSASHPMVD RWLEKQEQDE EGTEEDSSRV
260 270 280 290 300
EPVGHADTGL ENMPNFSLDD MVKLVQVPND GGPLGIHVVP FSARGGRTLG
310 320 330 340 350
LLVKRLEKGG KAEQENLFHE NDCIVRINDG DLRNRRFEQA QHMFRQAMRA
360 370 380 390 400
RVIWFHVVPA ANKEQYEQLS QREMNNYSPG RFSPDSHCVA NRSVANNAPQ
410 420 430 440 450
ALPRAPRLSQ PPEQLDAHPR LPHSAHASTK PPTAPALAPP NVLSTSVGSV
460 470 480 490 500
YNTKRVGKRL NIQLKKGTEG LGFSITSRDV TIGGSAPIYV KNILPRGAAI
510 520 530 540 550
QDGRLKAGDR LIEVNGVDLA GKSQEEVVSL LRSTKMEGTV SLLVFRQEEA
560 570 580 590 600
FHPREMNAEP SQMQSPKETK AEDEDIVLTP DGTREFLTFE VPLNDSGSAG
610 620 630 640 650
LGVSVKGNRS KENHADLGIF VKSIINGGAA SKDGRLRVND QLIAVNGESL
660 670 680 690 700
LGKANQEAME TLRRSMSTEG NKRGMIQLIV ARRISRCNEL RSPGSPAAPE
710 720 730 740 750
LPIETELDDR ERRISHSLYS GIEGLDESPT RNAALSRIMG ESGKCQLSPT
760 770 780 790 800
VNMPHDDTVM IEDDRLPVLP PHLSDQSSSS SHDDVGFIMT EAGTWAKATI
810 820 830 840 850
SDSADCSLSP DVDPVLAFQR EGFGRQSMSE KRTKQFSNAS QLDFVKTRKS
860 870 880 890 900
KSMDLGIADE TKLNTVDDQR AGSPNRDVGP SLGLKKSSSL ESLQTAVAEV
910 920 930 940 950
TLNGNIPFHR PRPRIIRGRG CNESFRAAID KSYDKPMVDD DDEGMETLEE
960 970 980 990 1000
DTEESSRSGR ESVSTSSDQP SYSLERQMNG DPEKRDKAEK KKDKAGKDKK
1010 1020 1030 1040 1050
KDREKEKDKL KAKKGMLKGL GDMFRFGKHR KDDKMEKMGR IKIQDSFTSE
1060 1070 1080 1090 1100
EDRVRMKEEQ ERIQAKTREF RERQARERDY AEIQDFHRTF GCDDELLYGG
1110 1120 1130 1140 1150
MSSYDGCLAL NARPQSPREG HLMDTLYAQV KKPRSSKPGD SNRSTPSNHD
1160 1170 1180 1190 1200
RIQRLRQEFQ QAKQDEDVED RRRTYSFEQS WSSSRPASQS GRHSVSVEVQ
1210 1220 1230 1240 1250
VQRQRQEERE SFQQAQRQYS SLPRQSRKNA SSVSQDSWEQ NYAPGEGFQS
1260 1270 1280 1290 1300
AKENPRYSSY QGSRNGYLGG HGFNARVMLE TQELLRQEQR RKEQQLKKQP
1310 1320 1330
PADGVRGPFR QDVPPSPSQV ARLNRLQTPE KGRPFYS
Length:1,337
Mass (Da):149,448
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC980C5106B52F9C
GO
Isoform 2 (identifier: Q9Z340-2) [UniParc]FASTAAdd to basket
Also known as: 150 kDa

The sequence of this isoform differs from the canonical sequence as follows:
     1034-1337: Missing.

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Length:1,033
Mass (Da):113,906
Checksum:i0E010FC4F6E2B2C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K9M8A0A0G2K9M8_RAT
Partitioning defective 3 homolog
Pard3
1,335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0074751034 – 1337Missing in isoform 2. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB005549 mRNA Translation: BAA34216.1

Protein sequence database of the Protein Information Resource

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PIRi
T13948

NCBI Reference Sequences

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RefSeqi
NP_112514.1, NM_031235.1 [Q9Z340-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSRNOT00000042623; ENSRNOP00000048964; ENSRNOG00000032437 [Q9Z340-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81918

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:81918

UCSC genome browser

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UCSCi
RGD:620374 rat [Q9Z340-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005549 mRNA Translation: BAA34216.1
PIRiT13948
RefSeqiNP_112514.1, NM_031235.1 [Q9Z340-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1ZNMR-A582-685[»]
2K20NMR-A582-685[»]
2NS5NMR-A2-83[»]
2OGPNMR-A454-550[»]
3ZEEelectron microscopy6.10A2-82[»]
4DC2X-ray2.40Z813-840[»]
4I6PX-ray2.90A/B2-83[»]
SMRiQ9Z340
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi249693, 3 interactors
CORUMiQ9Z340
DIPiDIP-33271N
IntActiQ9Z340, 2 interactors
MINTiQ9Z340
STRINGi10116.ENSRNOP00000048964

PTM databases

iPTMnetiQ9Z340
PhosphoSitePlusiQ9Z340

Proteomic databases

PaxDbiQ9Z340
PRIDEiQ9Z340

Genome annotation databases

EnsembliENSRNOT00000042623; ENSRNOP00000048964; ENSRNOG00000032437 [Q9Z340-1]
GeneIDi81918
KEGGirno:81918
UCSCiRGD:620374 rat [Q9Z340-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56288
RGDi620374 Pard3

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00950000183214
HOGENOMiHOG000232109
InParanoidiQ9Z340
KOiK04237
OMAiCNASSAN
OrthoDBi908238at2759
PhylomeDBiQ9Z340

Enzyme and pathway databases

ReactomeiR-RNO-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-RNO-420029 Tight junction interactions

Miscellaneous databases

EvolutionaryTraceiQ9Z340

Protein Ontology

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PROi
PR:Q9Z340

Gene expression databases

BgeeiENSRNOG00000032437 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiQ9Z340 baseline and differential
GenevisibleiQ9Z340 RN

Family and domain databases

InterProiView protein in InterPro
IPR021922 Par3/HAL_N
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF12053 Par3_HAL_N_term, 1 hit
PF00595 PDZ, 3 hits
SMARTiView protein in SMART
SM00228 PDZ, 3 hits
SUPFAMiSSF50156 SSF50156, 3 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPARD3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z340
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 1, 1999
Last modified: December 11, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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