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Protein

Serine/threonine-protein kinase SBK1

Gene

Sbk1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in signal-transduction pathways related to the control of brain development.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82ATPPROSITE-ProRule annotation1
Active sitei174Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SBK1 (EC:2.7.11.1)
Alternative name(s):
SH3-binding kinase 1
Gene namesi
Name:Sbk1
Synonyms:Sbk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628713 Sbk1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi73K → M: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002384531 – 417Serine/threonine-protein kinase SBK1Add BLAST417

Proteomic databases

PaxDbiQ9Z335
PRIDEiQ9Z335

PTM databases

PhosphoSitePlusiQ9Z335

Expressioni

Tissue specificityi

Mainly expressed in brain, with small amounts in heart, liver, kidney and heart.1 Publication

Developmental stagei

Detected in developing brain with a peak at E18.

Gene expression databases

BgeeiENSRNOG00000019082 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiQ9Z335 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025808

Structurei

3D structure databases

ProteinModelPortaliQ9Z335
SMRiQ9Z335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 318Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 393Pro-richAdd BLAST62

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1345 Eukaryota
ENOG41112JR LUCA
GeneTreeiENSGT00680000099954
HOGENOMiHOG000063666
HOVERGENiHBG108481
InParanoidiQ9Z335
KOiK08858
OMAiLTCCGPG
OrthoDBiEOG091G0QNH
PhylomeDBiQ9Z335
TreeFamiTF326736

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR016234 Ser/Thr_kinase_Sbk1
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF000566 Ser/Thr_PK_Sbk1, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z335-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGCPEPEP LHSLPCCGPG AAPVPGAGVP LLTEDMQALT LRTLAASDVT
60 70 80 90 100
KHYELVRELG KGTYGKVDLV AYKGTGTKMA LKFVNKSKTK LKNFLREVSI
110 120 130 140 150
TNSLSSSPFI IKVFDVVFET EECYVFAQEY APAGDLFDII PPQVGLPEDT
160 170 180 190 200
VKRCVQQLGL ALDFMHSRQL VHRDIKPENV LLFDRECRRV KLADFGMTRR
210 220 230 240 250
VGCRVKRVSG TIPYTAPEVC QAGRADGFAV DTGVDVWAFG VLIFCVLTGN
260 270 280 290 300
FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP
310 320 330 340 350
ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRLPGP LRLEAPGPLK
360 370 380 390 400
RTVLTESGSG SRPSPPSVGP VVPVPVPVPV PVPEAGLAPP APPGRTDGRA
410
DKSKGQVVLA TAIEICV
Length:417
Mass (Da):45,676
Last modified:May 1, 1999 - v1
Checksum:iC4D36608EE6EE208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010154 mRNA Translation: BAA36362.1
BC131843 mRNA Translation: AAI31844.1
RefSeqiNP_671476.1, NM_147135.2
XP_008757084.1, XM_008758862.2
XP_008757086.1, XM_008758864.2
XP_008758076.1, XM_008759854.2
XP_017444131.1, XM_017588642.1
UniGeneiRn.35152

Genome annotation databases

EnsembliENSRNOT00000025808; ENSRNOP00000025808; ENSRNOG00000019082
ENSRNOT00000082228; ENSRNOP00000073472; ENSRNOG00000057696
GeneIDi103690016
113907
KEGGirno:103690016
rno:113907
UCSCiRGD:628713 rat

Similar proteinsi

Entry informationi

Entry nameiSBK1_RAT
AccessioniPrimary (citable) accession number: Q9Z335
Secondary accession number(s): A2RRT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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