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Entry version 168 (17 Jun 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Atrial natriuretic peptide-converting enzyme

Gene

Corin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.5 Publications

Miscellaneous

Corin is disrupted in C57BL/6-Kit(W-sh/W-sh) mice, a genetic inversion used as mast cell-deficient model. Phenotypes in C57BL/6-Kit(W-sh/W-sh) mice are mainly due to the absence of Kit, a receptor for mast cell development. The absence of Corin probably leads to immediate significant cardiac hypertrophy and contractile dysfunction in response to pressure overload (PubMed:21903139).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei910Charge relay systemBy similarity1
Active sitei959Charge relay systemBy similarity1
Active sitei1052Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5578768 Physiological factors

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.019

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Atrial natriuretic peptide-converting enzyme (EC:3.4.21.-)
Alternative name(s):
Corin
Low density lipoprotein receptor-related protein 4
Pro-ANP-converting enzyme
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Corin
Synonyms:Crn, Lrp4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1349451 Corin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 112CytoplasmicSequence analysisAdd BLAST112
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei113 – 133Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini134 – 1113ExtracellularSequence analysisAdd BLAST980

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice develop normally, are viable and fertile but develop hypertension. They display increased body weight associated with impaired maturation of pro-NPPA which can be restored by injection of Corin. Spontaneous and salt-sensitive hypertension exacerbated during pregnancy is also noticed. A cardiac hypertrophy is also detected together with a decline in cardiac function later in life (PubMed:15637153). Blood pressure on a high-salt diet is significantly increased: knockout mice show an impairment of urinary sodium excretion and an increase in body weight, but no elevation of plasma renin or serum aldosterone levels (PubMed:22418978). Conditional knockout mice which express Corin in heart only do not display any visible phenotype in non-pregnant mice. In contrast, pregnant conditional knockout mice develop high blood pressure and proteinuria, characteristics of pre-eclampsia. In these mice, trophoblast invasion and uterine spiral artery remodeling are markedly impaired (PubMed:22437503).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000886741 – 1113Atrial natriuretic peptide-converting enzymeAdd BLAST1113
ChainiPRO_00003917671 – 867Atrial natriuretic peptide-converting enzyme, N-terminal propeptideBy similarityAdd BLAST867
ChainiPRO_0000417987? – 867Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragmentBy similarity
ChainiPRO_0000391768868 – 1113Atrial natriuretic peptide-converting enzyme, activated protease fragmentBy similarityAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi206 ↔ 266By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi214 ↔ 259By similarity
Disulfide bondi250 ↔ 290By similarity
Disulfide bondi279 ↔ 324By similarity
Disulfide bondi283 ↔ 307By similarity
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi337 ↔ 350By similarity
Disulfide bondi345 ↔ 363By similarity
Disulfide bondi357 ↔ 372By similarity
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi374 ↔ 386By similarity
Disulfide bondi381 ↔ 399By similarity
Disulfide bondi393 ↔ 408By similarity
Disulfide bondi410 ↔ 423By similarity
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi418 ↔ 436By similarity
Disulfide bondi430 ↔ 445By similarity
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi447 ↔ 460By similarity
Disulfide bondi455 ↔ 473By similarity
Disulfide bondi467 ↔ 482By similarity
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi523 ↔ 586By similarity
Disulfide bondi531 ↔ 579By similarity
Glycosylationi537N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi570 ↔ 608By similarity
Disulfide bondi597 ↔ 638By similarity
Disulfide bondi601 ↔ 625By similarity
Glycosylationi635N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi648 ↔ 660By similarity
Disulfide bondi655 ↔ 673By similarity
Disulfide bondi667 ↔ 682By similarity
Disulfide bondi684 ↔ 698By similarity
Disulfide bondi692 ↔ 711By similarity
Disulfide bondi705 ↔ 720By similarity
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi723 ↔ 735By similarity
Disulfide bondi730 ↔ 748By similarity
Disulfide bondi742 ↔ 757By similarity
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi782 ↔ 884By similarity
Glycosylationi828N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi857 ↔ 979Interchain (between N-terminal propeptide and activated protease fragment chains)PROSITE-ProRule annotation
Disulfide bondi895 ↔ 911By similarity
Glycosylationi970N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi993 ↔ 1058By similarity
Disulfide bondi1022 ↔ 1037By similarity
Disulfide bondi1048 ↔ 1077By similarity
Glycosylationi1089N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; required for processing and activation.By similarity
Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1 (By similarity).By similarity
A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei868 – 869CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3454

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Z319

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Z319

PRoteomics IDEntifications database

More...
PRIDEi
Q9Z319

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Z319

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Z319

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in heart. Also expressed in pregnant uterus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005220 Expressed in myocardium of ventricle and 106 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Z319 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000005352

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Z319 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Z319

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini201 – 327FZ 1PROSITE-ProRule annotationAdd BLAST127
Domaini336 – 372LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini373 – 408LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST36
Domaini409 – 445LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini446 – 483LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini518 – 641FZ 2PROSITE-ProRule annotationAdd BLAST124
Domaini647 – 682LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST36
Domaini683 – 721LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini722 – 757LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST36
Domaini758 – 853SRCRPROSITE-ProRule annotationAdd BLAST96
Domaini869 – 1102Peptidase S1PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3577 Eukaryota
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Z319

KEGG Orthology (KO)

More...
KOi
K09614

Database of Orthologous Groups

More...
OrthoDBi
1314811at2759

TreeFam database of animal gene trees

More...
TreeFami
TF351678

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07445 CRD_corin_1, 1 hit
cd07888 CRD_corin_2, 1 hit
cd00112 LDLa, 7 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 2 hits
4.10.400.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017052 Corin
IPR041762 Corin_CRD_1
IPR041763 Corin_CRD_2
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 6 hits
PF15494 SRCR_2, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036376 Corin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 7 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 7 hits
SSF63501 SSF63501, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z319-1) [UniParc]FASTAAdd to basket
Also known as: E1a, mE1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGRVSFSVRV SSVRRARCSC PGRCYLSCRV PPTTALRALN GLGCAGVPGE
60 70 80 90 100
TAGGAVGPGP LGTRGFLSGS KFQAPGSWKD CFGAPPAPDV LRADRSVGEG
110 120 130 140 150
CPQKLVTANL LRFLLLVLIP CICALIVLLA ILLSFVGTLK RVYFKSNDSE
160 170 180 190 200
PLVTDGEARV PGVIPVNTVY YENTGAPSLP PSQSTPAWTP RAPSPEDQSH
210 220 230 240 250
RNTSTCMNIT HSQCQILPYH STLAPLLPIV KNMDMEKFLK FFTYLHRLSC
260 270 280 290 300
YQHILLFGCS LAFPECVVDG DDRHGLLPCR SFCEAAKEGC ESVLGMVNSS
310 320 330 340 350
WPDSLRCSQF RDHTETNSSV RKSCFSLQQE HGKQSLCGGG ESFLCTSGLC
360 370 380 390 400
VPKKLQCNGY NDCDDWSDEA HCNCSKDLFH CGTGKCLHYS LLCDGYDDCG
410 420 430 440 450
DLSDEQNCDC NLTKEHRCGD GRCIAAEWVC DGDHDCVDKS DEVNCSCHSQ
460 470 480 490 500
GLVECRSGQC IPSTFQCDGD EDCKDGSDEE NCSDSQTPCP EGEQGCLGSS
510 520 530 540 550
CVESCAGSSL CDSDSSLSNC SQCEPITLEL CMNLPYNHTH YPNYLGHRTQ
560 570 580 590 600
KEASISWESS LFPALVQTNC YKYLMFFACT ILVPKCDVNT GQRIPPCRLL
610 620 630 640 650
CEHSKERCES VLGIVGLQWP EDTDCNQFPE ESSDNQTCLL PNEDVEECSP
660 670 680 690 700
SHFKCRSGRC VLGSRRCDGQ ADCDDDSDEE NCGCKERALW ECPFNKQCLK
710 720 730 740 750
HTLICDGFPD CPDSMDEKNC SFCQDNELEC ANHECVPRDL WCDGWVDCSD
760 770 780 790 800
SSDEWGCVTL SKNGNSSSLL TVHKSAKEHH VCADGWRETL SQLACKQMGL
810 820 830 840 850
GEPSVTKLIP GQEGQQWLRL YPNWENLNGS TLQELLVYRH SCPSRSEISL
860 870 880 890 900
LCSKQDCGRR PAARMNKRIL GGRTSRPGRW PWQCSLQSEP SGHICGCVLI
910 920 930 940 950
AKKWVLTVAH CFEGREDADV WKVVFGINNL DHPSGFMQTR FVKTILLHPR
960 970 980 990 1000
YSRAVVDYDI SVVELSDDIN ETSYVRPVCL PSPEEYLEPD TYCYITGWGH
1010 1020 1030 1040 1050
MGNKMPFKLQ EGEVRIIPLE QCQSYFDMKT ITNRMICAGY ESGTVDSCMG
1060 1070 1080 1090 1100
DSGGPLVCER PGGQWTLFGL TSWGSVCFSK VLGPGVYSNV SYFVGWIERQ
1110
IYIQTFLQKK SQG
Length:1,113
Mass (Da):123,006
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D002204779F8EA
GO
Isoform 2 (identifier: Q9Z319-2) [UniParc]FASTAAdd to basket
Also known as: E1, mE1

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MGRVSFSVRV...DCFGAPPAPD → MFTKRPPALAPEEYSRRADAPKR

Show »
Length:1,047
Mass (Da):116,697
Checksum:i2C434D652014A34D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLB2H3BLB2_MOUSE
Atrial natriuretic peptide-converti...
Corin
1,007Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLR7H3BLR7_MOUSE
Atrial natriuretic peptide-converti...
Corin
972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKS9H3BKS9_MOUSE
Atrial natriuretic peptide-converti...
Corin
980Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti402L → P in BAA34371 (PubMed:9756624).Curated1
Sequence conflicti456R → T in BAA34371 (PubMed:9756624).Curated1
Sequence conflicti497L → F in BAA34371 (PubMed:9756624).Curated1
Sequence conflicti535P → L in BAA34371 (PubMed:9756624).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0439531 – 89MGRVS…PPAPD → MFTKRPPALAPEEYSRRADA PKR in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB013874 mRNA Translation: BAA34371.1
AC129608 Genomic DNA No translation available.
AC161529 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37819.1
BC093485 mRNA Translation: AAH93485.1
BC138339 mRNA Translation: AAI38340.1
BC138340 mRNA Translation: AAI38341.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19330.1 [Q9Z319-1]
CCDS51513.1 [Q9Z319-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0315

NCBI Reference Sequences

More...
RefSeqi
NP_001116228.1, NM_001122756.1 [Q9Z319-2]
NP_058565.2, NM_016869.3 [Q9Z319-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000005352; ENSMUSP00000005352; ENSMUSG00000005220 [Q9Z319-1]
ENSMUST00000167460; ENSMUSP00000127389; ENSMUSG00000005220 [Q9Z319-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:53419

UCSC genome browser

More...
UCSCi
uc008xrj.2 mouse [Q9Z319-1]
uc008xrk.2 mouse [Q9Z319-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013874 mRNA Translation: BAA34371.1
AC129608 Genomic DNA No translation available.
AC161529 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37819.1
BC093485 mRNA Translation: AAH93485.1
BC138339 mRNA Translation: AAI38340.1
BC138340 mRNA Translation: AAI38341.1
CCDSiCCDS19330.1 [Q9Z319-1]
CCDS51513.1 [Q9Z319-2]
PIRiJE0315
RefSeqiNP_001116228.1, NM_001122756.1 [Q9Z319-2]
NP_058565.2, NM_016869.3 [Q9Z319-1]

3D structure databases

SMRiQ9Z319
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005352

Protein family/group databases

MEROPSiS01.019

PTM databases

iPTMnetiQ9Z319
PhosphoSitePlusiQ9Z319

Proteomic databases

CPTACinon-CPTAC-3454
jPOSTiQ9Z319
PaxDbiQ9Z319
PRIDEiQ9Z319

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23775 328 antibodies

Genome annotation databases

EnsembliENSMUST00000005352; ENSMUSP00000005352; ENSMUSG00000005220 [Q9Z319-1]
ENSMUST00000167460; ENSMUSP00000127389; ENSMUSG00000005220 [Q9Z319-2]
GeneIDi53419
KEGGimmu:53419
UCSCiuc008xrj.2 mouse [Q9Z319-1]
uc008xrk.2 mouse [Q9Z319-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10699
MGIiMGI:1349451 Corin

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
KOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000157103
InParanoidiQ9Z319
KOiK09614
OrthoDBi1314811at2759
TreeFamiTF351678

Enzyme and pathway databases

ReactomeiR-MMU-5578768 Physiological factors

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
53419 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Corin mouse

Protein Ontology

More...
PROi
PR:Q9Z319
RNActiQ9Z319 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005220 Expressed in myocardium of ventricle and 106 other tissues
GenevisibleiQ9Z319 MM

Family and domain databases

CDDicd07445 CRD_corin_1, 1 hit
cd07888 CRD_corin_2, 1 hit
cd00112 LDLa, 7 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di1.10.2000.10, 2 hits
4.10.400.10, 7 hits
InterProiView protein in InterPro
IPR017052 Corin
IPR041762 Corin_CRD_1
IPR041763 Corin_CRD_2
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01392 Fz, 2 hits
PF00057 Ldl_recept_a, 6 hits
PF15494 SRCR_2, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF036376 Corin, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00063 FRI, 2 hits
SM00192 LDLa, 7 hits
SM00202 SR, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 1 hit
SSF57424 SSF57424, 7 hits
SSF63501 SSF63501, 2 hits
PROSITEiView protein in PROSITE
PS50038 FZ, 2 hits
PS01209 LDLRA_1, 6 hits
PS50068 LDLRA_2, 7 hits
PS00420 SRCR_1, 1 hit
PS50287 SRCR_2, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCORIN_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Z319
Secondary accession number(s): B2RRC6, Q566K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: June 17, 2020
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
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