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Protein

U4/U6.U5 tri-snRNP-associated protein 1

Gene

Sart1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression.1 Publication

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 tri-snRNP-associated protein 1
Alternative name(s):
Hypoxia-associated factor
Squamous cell carcinoma antigen recognized by T-cells 1
Short name:
SART-1
Short name:
mSART-1
Gene namesi
Name:Sart1
Synonyms:Haf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1309453 Sart1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002233091 – 806U4/U6.U5 tri-snRNP-associated protein 1Add BLAST806

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei189PhosphothreonineCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei321PhosphoserineBy similarity1
Cross-linki329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei348PhosphoserineBy similarity1
Cross-linki400Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki414Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei430PhosphothreonineBy similarity1
Modified residuei480PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei527PhosphoserineBy similarity1
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei597PhosphoserineBy similarity1
Modified residuei602PhosphoserineBy similarity1
Modified residuei604PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Cross-linki654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki663Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki690Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei701PhosphothreonineBy similarity1
Cross-linki705Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki715Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki729Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki755Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki764Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei767PhosphoserineBy similarity1
Modified residuei770PhosphothreonineBy similarity1
Cross-linki781Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki786Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei795PhosphoserineBy similarity1
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Sumoylated with SUMO2.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z315
MaxQBiQ9Z315
PaxDbiQ9Z315
PeptideAtlasiQ9Z315
PRIDEiQ9Z315

PTM databases

iPTMnetiQ9Z315
PhosphoSitePlusiQ9Z315

Expressioni

Tissue specificityi

Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver.1 Publication

Developmental stagei

Expressed at maximal level at E12. Declines progressively until birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000039148 Expressed in 304 organ(s), highest expression level in ear
GenevisibleiQ9Z315 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203075, 25 interactors
IntActiQ9Z315, 26 interactors
MINTiQ9Z315
STRINGi10090.ENSMUSP00000047397

Structurei

3D structure databases

ProteinModelPortaliQ9Z315
SMRiQ9Z315
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili157 – 231Sequence analysisAdd BLAST75
Coiled coili494 – 540Sequence analysisAdd BLAST47

Sequence similaritiesi

Belongs to the SNU66/SART1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2217 Eukaryota
ENOG410XSTT LUCA
GeneTreeiENSGT00390000007071
HOGENOMiHOG000046291
HOVERGENiHBG052942
InParanoidiQ9Z315
KOiK11984
OMAiARWENKQ
OrthoDBiEOG091G04IE
PhylomeDBiQ9Z315
TreeFamiTF318828

Family and domain databases

InterProiView protein in InterPro
IPR005011 SNU66/SART1
PANTHERiPTHR14152 PTHR14152, 1 hit
PfamiView protein in Pfam
PF03343 SART-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG
60 70 80 90 100
ERRKRSRERG SERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDD
110 120 130 140 150
GYEAAASSKA SSGDASSLSI EETNKLRAKL GLKPLEVNAV KKEAGTKEEP
160 170 180 190 200
VAADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT
210 220 230 240 250
AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FEQRRQDLYS
260 270 280 290 300
ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQDGEDVLV NVNMVDKERA
310 320 330 340 350
DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR
360 370 380 390 400
LEQGGMADGL RERELEEIRT KLRLQAQSLS SVGPRLASEY LSPEEMVTFK
410 420 430 440 450
KTKRRVKKIR KKEKEVIMRA DDLLPLGDQT QDGDFGSRLR GRGRRRVPEV
460 470 480 490 500
EEEALEDEEK DPVAQPPPSD DTRVENMDIS DEEDGGALPP GSPEGLEEDE
510 520 530 540 550
AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES RQRGWEEEED
560 570 580 590 600
PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG
610 620 630 640 650
GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL
660 670 680 690 700
CQNKGLLETT VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF
710 720 730 740 750
TQDFKEKDGY KPDVKIEYVD ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE
760 770 780 790 800
RRMKKLDEEA LLKKMSSSDT PLGTVALLQE KQKAQKTPYI VLSGSGKSMN

ANTITK
Length:806
Mass (Da):90,885
Last modified:May 1, 1999 - v1
Checksum:i1417E85C71BF380C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70A → T in AAD20645 (PubMed:10887110).Curated1
Sequence conflicti70A → T in AAH28823 (PubMed:15489334).Curated1
Sequence conflicti70A → T in AAH51394 (PubMed:15489334).Curated1
Sequence conflicti566C → Y in AAD20645 (PubMed:10887110).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014721 mRNA Translation: BAA36583.1
AF129931 mRNA Translation: AAD20645.1
BC028823 mRNA Translation: AAH28823.1
BC051394 mRNA Translation: AAH51394.1
AF105334 Genomic DNA Translation: AAD38450.1
CCDSiCCDS29460.1
RefSeqiNP_058578.3, NM_016882.3
UniGeneiMm.34562

Genome annotation databases

EnsembliENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148
GeneIDi20227
KEGGimmu:20227
UCSCiuc008gcu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014721 mRNA Translation: BAA36583.1
AF129931 mRNA Translation: AAD20645.1
BC028823 mRNA Translation: AAH28823.1
BC051394 mRNA Translation: AAH51394.1
AF105334 Genomic DNA Translation: AAD38450.1
CCDSiCCDS29460.1
RefSeqiNP_058578.3, NM_016882.3
UniGeneiMm.34562

3D structure databases

ProteinModelPortaliQ9Z315
SMRiQ9Z315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203075, 25 interactors
IntActiQ9Z315, 26 interactors
MINTiQ9Z315
STRINGi10090.ENSMUSP00000047397

PTM databases

iPTMnetiQ9Z315
PhosphoSitePlusiQ9Z315

Proteomic databases

EPDiQ9Z315
MaxQBiQ9Z315
PaxDbiQ9Z315
PeptideAtlasiQ9Z315
PRIDEiQ9Z315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148
GeneIDi20227
KEGGimmu:20227
UCSCiuc008gcu.1 mouse

Organism-specific databases

CTDi9092
MGIiMGI:1309453 Sart1

Phylogenomic databases

eggNOGiKOG2217 Eukaryota
ENOG410XSTT LUCA
GeneTreeiENSGT00390000007071
HOGENOMiHOG000046291
HOVERGENiHBG052942
InParanoidiQ9Z315
KOiK11984
OMAiARWENKQ
OrthoDBiEOG091G04IE
PhylomeDBiQ9Z315
TreeFamiTF318828

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q9Z315
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039148 Expressed in 304 organ(s), highest expression level in ear
GenevisibleiQ9Z315 MM

Family and domain databases

InterProiView protein in InterPro
IPR005011 SNU66/SART1
PANTHERiPTHR14152 PTHR14152, 1 hit
PfamiView protein in Pfam
PF03343 SART-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNUT1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z315
Secondary accession number(s): Q8K155, Q9R1I9, Q9R270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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