Sart1

Functionⁱ

Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression.1 Publication

GO - Biological processⁱ

maturation of 5S rRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA cis splicing, via spliceosome
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mRNA splicing, via spliceosome Source: MGI
positive regulation of cytotoxic T cell differentiation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	mRNA processing, mRNA splicing

Biological process

mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U4/U6.U5 tri-snRNP-associated protein 1 Alternative name(s): Hypoxia-associated factor Squamous cell carcinoma antigen recognized by T-cells 1 Short name: SART-1 Short name: mSART-1
Gene namesⁱ	Name:Sart1 Synonyms:Haf
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:1309453 Sart1

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000223309	1 – 806	U4/U6.U5 tri-snRNP-associated protein 1Add BLAST		806

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	125	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	133	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	141	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	141	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	147	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	188	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	189	PhosphothreonineCombined sources	1
Cross-linkⁱ	277	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	321	PhosphoserineBy similarity	1
Cross-linkⁱ	329	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	336	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	348	PhosphoserineBy similarity	1
Cross-linkⁱ	400	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	414	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	430	PhosphothreonineBy similarity	1
Modified residueⁱ	480	PhosphoserineCombined sources	1
Modified residueⁱ	492	PhosphoserineBy similarity	1
Modified residueⁱ	527	PhosphoserineBy similarity	1
Cross-linkⁱ	554	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	597	PhosphoserineBy similarity	1
Modified residueⁱ	602	PhosphoserineBy similarity	1
Modified residueⁱ	604	PhosphoserineBy similarity	1
Modified residueⁱ	627	PhosphoserineBy similarity	1
Cross-linkⁱ	654	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	663	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	690	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	701	PhosphothreonineBy similarity	1
Cross-linkⁱ	705	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	715	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	729	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	755	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	764	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	767	PhosphoserineBy similarity	1
Modified residueⁱ	770	PhosphothreonineBy similarity	1
Cross-linkⁱ	781	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	786	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	795	PhosphoserineBy similarity	1
Cross-linkⁱ	797	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Sumoylated with SUMO2.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9Z315
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Z315
PaxDbⁱ	Q9Z315
PeptideAtlas More...PeptideAtlasⁱ	Q9Z315
PRIDEⁱ	Q9Z315

PTM databases

iPTMnetⁱ	Q9Z315
PhosphoSitePlusⁱ	Q9Z315

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Shows a high expression in fetal liver and a low expression in adult liver.1 Publication

Developmental stageⁱ

Expressed at maximal level at E12. Declines progressively until birth.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000039148 Expressed in 304 organ(s), highest expression level in ear
Genevisibleⁱ	Q9Z315 MM

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	203075, 25 interactors
IntActⁱ	Q9Z315, 26 interactors
Molecular INTeraction database More...MINTⁱ	Q9Z315
STRINGⁱ	10090.ENSMUSP00000047397

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Z315
SMRⁱ	Q9Z315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	157 – 231	Sequence analysisAdd BLAST		75
Coiled coilⁱ	494 – 540	Sequence analysisAdd BLAST		47

Sequence similaritiesⁱ

Belongs to the SNU66/SART1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2217 Eukaryota ENOG410XSTT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000007071
HOGENOMⁱ	HOG000046291
HOVERGENⁱ	HBG052942
InParanoidⁱ	Q9Z315
KEGG Orthology (KO) More...KOⁱ	K11984
OMAⁱ	ARWENKQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04IE
PhylomeDBⁱ	Q9Z315
TreeFamⁱ	TF318828

Family and domain databases

InterProⁱ	View protein in InterPro IPR005011 SNU66/SART1
PANTHERⁱ	PTHR14152 PTHR14152, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03343 SART-1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Z315-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSSKKHRGE KEAAGTTAAA GTGGTTEQPP RHREHKKHKH RSSGGGSSGG 
        60         70         80         90        100
ERRKRSRERG SERGSGRRGA EAEARSGAHG RERSQAEPSE RRVKREKRDD 
       110        120        130        140        150
GYEAAASSKA SSGDASSLSI EETNKLRAKL GLKPLEVNAV KKEAGTKEEP 
       160        170        180        190        200
VAADVINPMA LRQREELREK LAAAKEKRLL NQKLGKIKTL GEDDPWLDDT 
       210        220        230        240        250
AAWIERSRQL QKEKDLAEKR AKLLEEMDQE FGVSTLVEEE FEQRRQDLYS 
       260        270        280        290        300
ARDLQGLTVE HAIDSFREGE TVVLTLKDKG VLQDGEDVLV NVNMVDKERA 
       310        320        330        340        350
DKNVELRKKK PDYLPYAEDE SVDDLAQQKP RSILAKYDEE LEGERPHSFR 
       360        370        380        390        400
LEQGGMADGL RERELEEIRT KLRLQAQSLS SVGPRLASEY LSPEEMVTFK 
       410        420        430        440        450
KTKRRVKKIR KKEKEVIMRA DDLLPLGDQT QDGDFGSRLR GRGRRRVPEV 
       460        470        480        490        500
EEEALEDEEK DPVAQPPPSD DTRVENMDIS DEEDGGALPP GSPEGLEEDE 
       510        520        530        540        550
AELELQKQLE KGRRLRQLQQ LQQLRDSGEK VLEIVKKLES RQRGWEEEED 
       560        570        580        590        600
PERKGTIVFN ATSEFCRTLG EIPTYGLAGN REEQEELMDF ERDEERSANG 
       610        620        630        640        650
GSESDGEENI GWSTVNLDEE KQHQDFSASS TTILDEEPIV NRGLAAALLL 
       660        670        680        690        700
CQNKGLLETT VQKVARVKAP NKSLPSAVYC IEDKMAIDDK YSRREEYRGF 
       710        720        730        740        750
TQDFKEKDGY KPDVKIEYVD ETGRKLTPKE AFRQLSHRFH GKGSGKMKTE 
       760        770        780        790        800
RRMKKLDEEA LLKKMSSSDT PLGTVALLQE KQKAQKTPYI VLSGSGKSMN 

ANTITK

Length:806

Mass (Da):90,885

Last modified:May 1, 1999 - v1

Checksum:ⁱ1417E85C71BF380C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	70	A → T in AAD20645 (PubMed:10887110).Curated	1
Sequence conflictⁱ	70	A → T in AAH28823 (PubMed:15489334).Curated	1
Sequence conflictⁱ	70	A → T in AAH51394 (PubMed:15489334).Curated	1
Sequence conflictⁱ	566	C → Y in AAD20645 (PubMed:10887110).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB014721 mRNA Translation: BAA36583.1 AF129931 mRNA Translation: AAD20645.1 BC028823 mRNA Translation: AAH28823.1 BC051394 mRNA Translation: AAH51394.1 AF105334 Genomic DNA Translation: AAD38450.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29460.1
NCBI Reference Sequences More...RefSeqⁱ	NP_058578.3, NM_016882.3
UniGeneⁱ	Mm.34562

Genome annotation databases

Ensemblⁱ	ENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148
GeneIDⁱ	20227
KEGGⁱ	mmu:20227
UCSC genome browser More...UCSCⁱ	uc008gcu.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z315	U4/U6.U5 tri-snRNP-associated protein 1		RAT		806	UniRef90_Q9Z315
U4/U6.U5 tri-snRNP-associated protein 1		wild yak		823
Squamous cell carcinoma antigen recognized by T-cells 1-like protein (Fragment)		BOVIN		199
Uncharacterized protein		NEOLE		815
Uncharacterized protein		MYOLU		806
+37

Protein	Similar proteins		Species	Score	Length	Source
Q9Z315	U4/U6.U5 tri-snRNP-associated protein 1	)	HUMAN		800	UniRef50_O43290
U4/U6.U5 tri-snRNP-associated protein 1		RAT		806
Uncharacterized protein		AOTNA		876
U4/U6.U5 tri-snRNP-associated protein 1 isoform X1		ODORO		806
U4/U6.U5 tri-snRNP-associated protein 1		CASCN		806
+262

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB014721 mRNA Translation: BAA36583.1 AF129931 mRNA Translation: AAD20645.1 BC028823 mRNA Translation: AAH28823.1 BC051394 mRNA Translation: AAH51394.1 AF105334 Genomic DNA Translation: AAD38450.1
CCDSⁱ	CCDS29460.1
RefSeqⁱ	NP_058578.3, NM_016882.3
UniGeneⁱ	Mm.34562

3D structure databases

ProteinModelPortalⁱ	Q9Z315
SMRⁱ	Q9Z315
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	203075, 25 interactors
IntActⁱ	Q9Z315, 26 interactors
MINTⁱ	Q9Z315
STRINGⁱ	10090.ENSMUSP00000047397

PTM databases

iPTMnetⁱ	Q9Z315
PhosphoSitePlusⁱ	Q9Z315

Proteomic databases

EPDⁱ	Q9Z315
MaxQBⁱ	Q9Z315
PaxDbⁱ	Q9Z315
PeptideAtlasⁱ	Q9Z315
PRIDEⁱ	Q9Z315

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000044207; ENSMUSP00000047397; ENSMUSG00000039148
GeneIDⁱ	20227
KEGGⁱ	mmu:20227
UCSCⁱ	uc008gcu.1 mouse

Organism-specific databases

CTDⁱ	9092
MGIⁱ	MGI:1309453 Sart1

Phylogenomic databases

eggNOGⁱ	KOG2217 Eukaryota ENOG410XSTT LUCA
GeneTreeⁱ	ENSGT00390000007071
HOGENOMⁱ	HOG000046291
HOVERGENⁱ	HBG052942
InParanoidⁱ	Q9Z315
KOⁱ	K11984
OMAⁱ	ARWENKQ
OrthoDBⁱ	EOG091G04IE
PhylomeDBⁱ	Q9Z315
TreeFamⁱ	TF318828

Enzyme and pathway databases

Reactomeⁱ	R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9Z315
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039148 Expressed in 304 organ(s), highest expression level in ear
Genevisibleⁱ	Q9Z315 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR005011 SNU66/SART1
PANTHERⁱ	PTHR14152 PTHR14152, 1 hit
Pfamⁱ	View protein in Pfam PF03343 SART-1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNUT1_MOUSE
Accessionⁱ	Q9Z315Primary (citable) accession number: Q9Z315 Secondary accession number(s): Q8K155, Q9R1I9, Q9R270
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	May 1, 1999
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z315 (SNUT1_MOUSE)

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U4/U6.U5 tri-snRNP-associated protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Golgi apparatus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ