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Protein

7-dehydrocholesterol reductase

Gene

Dhcr7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei354NADPBy similarity1
Binding sitei358NADPBy similarity1
Binding sitei391NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei396NADPBy similarity1
Binding sitei443NADPBy similarity1
Binding sitei458NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi403 – 404NADPBy similarity2
Nucleotide bindingi447 – 451NADPBy similarity5

GO - Molecular functioni

  • 7-dehydrocholesterol reductase activity Source: RGD
  • NADP binding Source: UniProtKB
  • sterol delta7 reductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.3.1.21 5301
ReactomeiR-RNO-6807047 Cholesterol biosynthesis via desmosterol
R-RNO-6807062 Cholesterol biosynthesis via lathosterol
UniPathwayiUPA00063

Names & Taxonomyi

Protein namesi
Recommended name:
7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:Dhcr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621769 Dhcr7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4965

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075041 – 4717-dehydrocholesterol reductaseAdd BLAST471

Proteomic databases

PaxDbiQ9Z2Z8
PRIDEiQ9Z2Z8

PTM databases

SwissPalmiQ9Z2Z8

Expressioni

Gene expression databases

BgeeiENSRNOG00000020776
GenevisibleiQ9Z2Z8 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028194

Chemistry databases

BindingDBiQ9Z2Z8

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1435 Eukaryota
ENOG410XP67 LUCA
GeneTreeiENSGT00390000000417
HOGENOMiHOG000193296
HOVERGENiHBG007825
InParanoidiQ9Z2Z8
KOiK00213
OMAiTNHQKDL
PhylomeDBiQ9Z2Z8
TreeFamiTF101180

Family and domain databases

InterProiView protein in InterPro
IPR001171 Ergosterol_biosynth_ERG4_ERG24
IPR018083 Sterol_reductase_CS
PfamiView protein in Pfam
PF01222 ERG4_ERG24, 1 hit
PROSITEiView protein in PROSITE
PS01017 STEROL_REDUCT_1, 1 hit
PS01018 STEROL_REDUCT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Z2Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKSQHNAS KAKNHNVKAE SQGQWGRAWE VDWFSLVSVI FLLLFAPFIV
60 70 80 90 100
YYFIMACDQY SCSLTAPILD VATGRASLAD IWAKTPPVTA KAAQLYALWV
110 120 130 140 150
SFQVLLYSWL PDFCHRFLPG YVGGVQEGAI TPAGIVNKYE VNGLQAWLIT
160 170 180 190 200
HFLWFVNAYL LSWFSPTIIF DNWIPLLWCA NILGYAVSTF AMIKGYLFPT
210 220 230 240 250
SAEDCKFTGN FFYNYMMGIE FNPRIGKWFD FKLFFNGRPG IVAWTLINLS
260 270 280 290 300
FAAKQQELYG HVTNSMILVN VLQAIYVLDF FWNETWYLKT IDICHDHFGW
310 320 330 340 350
YLGWGDCVWL PYLYTLQGLY LVYHPVQLST PNALGVLLLG LVGYYIFRMT
360 370 380 390 400
NHQKDLFRRT DGHCLIWGKK PKAIECSYTS ADGLKHRSKL LVSGFWGVAR
410 420 430 440 450
HFNYTGDLMG SLAYCLACGG GHLLPYFYII YMTILLTHRC LRDEHRCANK
460 470
YGRDWERYVA AVPYRLLPGI F
Length:471
Mass (Da):54,155
Last modified:May 1, 1999 - v1
Checksum:iEBF0CBC4F4222FDB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016800 mRNA Translation: BAA34306.1
AF071500 mRNA Translation: AAD31383.1
AF272393 mRNA Translation: AAM45144.1
AF279892 Genomic DNA Translation: AAK69490.1
BC081688 mRNA Translation: AAH81688.1
RefSeqiNP_071784.1, NM_022389.2
XP_006230954.1, XM_006230892.3
XP_006230955.1, XM_006230893.3
XP_006230956.1, XM_006230894.3
XP_008758394.1, XM_008760172.2
XP_008758395.1, XM_008760173.2
UniGeneiRn.228

Genome annotation databases

EnsembliENSRNOT00000028195; ENSRNOP00000028194; ENSRNOG00000020776
ENSRNOT00000078979; ENSRNOP00000071939; ENSRNOG00000020776
GeneIDi64191
KEGGirno:64191
UCSCiRGD:621769 rat

Similar proteinsi

Entry informationi

Entry nameiDHCR7_RAT
AccessioniPrimary (citable) accession number: Q9Z2Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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