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Protein

Homer protein homolog 1

Gene

Homer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Protein family/group databases

TCDBi8.A.29.1.1 the homer1 (homer1) family of excitation-contraction coupling proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 1Curated
Short name:
Homer-1
Alternative name(s):
VASP/Ena-related gene up-regulated during seizure and LTP 1
Short name:
Vesl-11 Publication
Gene namesi
Name:Homer1Imported
Synonyms:Vesl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347345 Homer1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001910062 – 366Homer protein homolog 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei318PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9Z2Y3
PeptideAtlasiQ9Z2Y3
PRIDEiQ9Z2Y3

PTM databases

iPTMnetiQ9Z2Y3
PhosphoSitePlusiQ9Z2Y3

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 5 are expressed in skeletal muscle at the level of the Z line, in heart, forebrain and cerebellum. Isoform 2, is a minor isoform and is expressed in cardiac and skeletal muscle. Isoform 5 is expressed in the postsynaptic region of neurons.2 Publications

Gene expression databases

BgeeiENSMUSG00000007617 Expressed in 274 organ(s), highest expression level in cerebral cortex
CleanExiMM_HOMER1
ExpressionAtlasiQ9Z2Y3 baseline and differential
GenevisibleiQ9Z2Y3 MM

Interactioni

Subunit structurei

Tetramer; this tetrameric structure is critical for forming the high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Isoform 1, isoform 2 and isoform 3 encode a coiled-coil structure that mediates homo- and heteromultimerization. Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2 and SHANK3. Interacts with IFT57 and OPHN1. Interacts with SHANK1; forms high-order polymerized complex with a mesh-like network structure, at least composed of SHANK1, HOMER1 and DLGAP1; the complex formation is SHANK1 multimerization dependent (By similarity).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlgap1Q9D4154EBI-396980,EBI-400152

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205014, 55 interactors
CORUMiQ9Z2Y3
IntActiQ9Z2Y3, 51 interactors
MINTiQ9Z2Y3
STRINGi10090.ENSMUSP00000078093

Structurei

3D structure databases

ProteinModelPortaliQ9Z2Y3
SMRiQ9Z2Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110WH1PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni302 – 366Required for tetramerizationBy similarityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 364Sequence analysisAdd BLAST172

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. The coiled-Coil domain forms an antiparallel tetrameric arrangement (By similarity).By similarity

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ9Z2Y3
KOiK15010
OMAiQNSEPRP
OrthoDBiEOG091G0CQ0
PhylomeDBiQ9Z2Y3
TreeFamiTF325627

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Z2Y3-1) [UniParc]FASTAAdd to basket
Also known as: Vesl-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL
60 70 80 90 100
DGSKAIINST ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA
110 120 130 140 150
EKFQEFKEAA RLAKEKSQEK MELTSTPSQE SAGGDLQSPL TPESINGTDD
160 170 180 190 200
ERTPDVTQNS EPRAEPTQNA LPFPHSAGDR TQALSHASSA ISKHWEAELA
210 220 230 240 250
TLKGNNAKLT AALLESTANV KQWKQQLAAY QEEAERLHKR VTELECVSSQ
260 270 280 290 300
ANAVHSHKTE LNQTVQELEE TLKVKEEEIE RLKQEIDNAR ELQEQRDSLT
310 320 330 340 350
QKLQEVEIRN KDLEGQLSDL EQRLEKSQNE QEAFRSNLKT LLEILDGKIF
360
ELTELRDNLA KLLECS
Length:366
Mass (Da):41,413
Last modified:November 28, 2003 - v2
Checksum:i6A4CBCE5B8A91A3F
GO
Isoform 2 (identifier: Q9Z2Y3-2) [UniParc]FASTAAdd to basket
Also known as: 1d

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MG → MLIHHHNRRALCKGSPTT
     176-187: Missing.

Show »
Length:370
Mass (Da):42,084
Checksum:iABBDD4A4184E2233
GO
Isoform 3 (identifier: Q9Z2Y3-3) [UniParc]FASTAAdd to basket
Also known as: 1b

The sequence of this isoform differs from the canonical sequence as follows:
     176-187: Missing.

Show »
Length:354
Mass (Da):40,218
Checksum:iF01D84B0A87E168C
GO
Isoform 4 (identifier: Q9Z2Y3-4) [UniParc]FASTAAdd to basket
Also known as: Vesl-1M

The sequence of this isoform differs from the canonical sequence as follows:
     177-203: AGDRTQALSHASSAISKHWEAELATLK → SSRWIFFPYCEDSQLSLLESSSGLGYF
     204-366: Missing.

Show »
Length:203
Mass (Da):22,775
Checksum:i19461F47996D04C3
GO
Isoform 5 (identifier: Q9Z2Y3-5) [UniParc]FASTAAdd to basket
Also known as: Vesl-1S

The sequence of this isoform differs from the canonical sequence as follows:
     176-186: SAGDRTQALSH → RYTFNSAIMIK
     187-366: Missing.

Show »
Length:186
Mass (Da):20,912
Checksum:i9845DA75270BBF83
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6A7D3Z6A7_MOUSE
Homer protein homolog 1
Homer1
224Annotation score:
E9Q0I8E9Q0I8_MOUSE
Homer protein homolog 1
Homer1
180Annotation score:
E9Q0I7E9Q0I7_MOUSE
Homer protein homolog 1
Homer1
192Annotation score:
Q3UVL6Q3UVL6_MOUSE
Homer protein homolog 1
Homer1
193Annotation score:
D3Z6A8D3Z6A8_MOUSE
Homer protein homolog 1
Homer1
191Annotation score:
D3Z6A9D3Z6A9_MOUSE
Homer protein homolog 1
Homer1
233Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti193K → N in BAA34354 (Ref. 3) Curated1
Sequence conflicti197A → V in BAA34354 (Ref. 3) Curated1
Sequence conflicti205N → T in BAA34354 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0090601 – 2MG → MLIHHHNRRALCKGSPTT in isoform 2. 1 Publication2
Alternative sequenceiVSP_009061176 – 187Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_009062176 – 186SAGDRTQALSH → RYTFNSAIMIK in isoform 5. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_009063177 – 203AGDRT…LATLK → SSRWIFFPYCEDSQLSLLES SSGLGYF in isoform 4. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_009064187 – 366Missing in isoform 5. 2 PublicationsAdd BLAST180
Alternative sequenceiVSP_009065204 – 366Missing in isoform 4. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093257 mRNA Translation: AAC71021.1
AF093258 mRNA Translation: AAC71022.1
AY137385 mRNA Translation: AAM95461.1
AB019478 mRNA Translation: BAA34353.1
AB019479 mRNA Translation: BAA34354.1
AB089435 mRNA Translation: BAC07257.1
CCDSiCCDS26687.1 [Q9Z2Y3-5]
CCDS36745.1 [Q9Z2Y3-1]
CCDS36746.1 [Q9Z2Y3-2]
CCDS70484.1 [Q9Z2Y3-3]
CCDS84048.1 [Q9Z2Y3-4]
RefSeqiNP_001271118.1, NM_001284189.2 [Q9Z2Y3-3]
NP_001334527.1, NM_001347598.1 [Q9Z2Y3-4]
NP_036112.1, NM_011982.4 [Q9Z2Y3-5]
NP_671705.2, NM_147176.4 [Q9Z2Y3-1]
NP_687036.1, NM_152134.3 [Q9Z2Y3-2]
UniGeneiMm.37533
Mm.443111

Genome annotation databases

EnsembliENSMUST00000060490; ENSMUSP00000050471; ENSMUSG00000007617 [Q9Z2Y3-3]
ENSMUST00000079086; ENSMUSP00000078093; ENSMUSG00000007617 [Q9Z2Y3-2]
ENSMUST00000080127; ENSMUSP00000079026; ENSMUSG00000007617 [Q9Z2Y3-1]
ENSMUST00000102752; ENSMUSP00000099813; ENSMUSG00000007617 [Q9Z2Y3-5]
ENSMUST00000109492; ENSMUSP00000105118; ENSMUSG00000007617 [Q9Z2Y3-4]
GeneIDi26556
KEGGimmu:26556
UCSCiuc007rlc.3 mouse [Q9Z2Y3-1]
uc007rld.3 mouse [Q9Z2Y3-3]
uc007rle.3 mouse [Q9Z2Y3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093257 mRNA Translation: AAC71021.1
AF093258 mRNA Translation: AAC71022.1
AY137385 mRNA Translation: AAM95461.1
AB019478 mRNA Translation: BAA34353.1
AB019479 mRNA Translation: BAA34354.1
AB089435 mRNA Translation: BAC07257.1
CCDSiCCDS26687.1 [Q9Z2Y3-5]
CCDS36745.1 [Q9Z2Y3-1]
CCDS36746.1 [Q9Z2Y3-2]
CCDS70484.1 [Q9Z2Y3-3]
CCDS84048.1 [Q9Z2Y3-4]
RefSeqiNP_001271118.1, NM_001284189.2 [Q9Z2Y3-3]
NP_001334527.1, NM_001347598.1 [Q9Z2Y3-4]
NP_036112.1, NM_011982.4 [Q9Z2Y3-5]
NP_671705.2, NM_147176.4 [Q9Z2Y3-1]
NP_687036.1, NM_152134.3 [Q9Z2Y3-2]
UniGeneiMm.37533
Mm.443111

3D structure databases

ProteinModelPortaliQ9Z2Y3
SMRiQ9Z2Y3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205014, 55 interactors
CORUMiQ9Z2Y3
IntActiQ9Z2Y3, 51 interactors
MINTiQ9Z2Y3
STRINGi10090.ENSMUSP00000078093

Protein family/group databases

TCDBi8.A.29.1.1 the homer1 (homer1) family of excitation-contraction coupling proteins

PTM databases

iPTMnetiQ9Z2Y3
PhosphoSitePlusiQ9Z2Y3

Proteomic databases

PaxDbiQ9Z2Y3
PeptideAtlasiQ9Z2Y3
PRIDEiQ9Z2Y3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060490; ENSMUSP00000050471; ENSMUSG00000007617 [Q9Z2Y3-3]
ENSMUST00000079086; ENSMUSP00000078093; ENSMUSG00000007617 [Q9Z2Y3-2]
ENSMUST00000080127; ENSMUSP00000079026; ENSMUSG00000007617 [Q9Z2Y3-1]
ENSMUST00000102752; ENSMUSP00000099813; ENSMUSG00000007617 [Q9Z2Y3-5]
ENSMUST00000109492; ENSMUSP00000105118; ENSMUSG00000007617 [Q9Z2Y3-4]
GeneIDi26556
KEGGimmu:26556
UCSCiuc007rlc.3 mouse [Q9Z2Y3-1]
uc007rld.3 mouse [Q9Z2Y3-3]
uc007rle.3 mouse [Q9Z2Y3-2]

Organism-specific databases

CTDi9456
MGIiMGI:1347345 Homer1

Phylogenomic databases

eggNOGiENOG410IGRQ Eukaryota
ENOG410XQWT LUCA
GeneTreeiENSGT00390000017850
HOGENOMiHOG000006979
HOVERGENiHBG051918
InParanoidiQ9Z2Y3
KOiK15010
OMAiQNSEPRP
OrthoDBiEOG091G0CQ0
PhylomeDBiQ9Z2Y3
TreeFamiTF325627

Enzyme and pathway databases

ReactomeiR-MMU-6794361 Neurexins and neuroligins

Miscellaneous databases

PROiPR:Q9Z2Y3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007617 Expressed in 274 organ(s), highest expression level in cerebral cortex
CleanExiMM_HOMER1
ExpressionAtlasiQ9Z2Y3 baseline and differential
GenevisibleiQ9Z2Y3 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHOME1_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2Y3
Secondary accession number(s): Q8K3E1
, Q8K4M8, Q9Z0E9, Q9Z216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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