UniProtKB - Q9Z2X5 (HOME3_RAT)
Homer protein homolog 3
Homer3
Functioni
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release (By similarity).
Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).
By similarityGO - Molecular functioni
- G protein-coupled glutamate receptor binding Source: GO_Central
- identical protein binding Source: RGD
- protein C-terminus binding Source: RGD
- protein domain specific binding Source: RGD
GO - Biological processi
- G protein-coupled glutamate receptor signaling pathway Source: GO_Central
- negative regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- negative regulation of interleukin-2 production Source: UniProtKB
- regulation of postsynaptic neurotransmitter receptor activity Source: RGD
- regulation of store-operated calcium entry Source: GO_Central
Enzyme and pathway databases
Reactomei | R-RNO-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Homer protein homolog 3CuratedShort name: Homer-3 Alternative name(s): VASP/Ena-related gene up-regulated during seizure and LTP 3 Short name: Vesl-31 Publication |
Gene namesi | |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620706, Homer3 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- postsynaptic density By similarity
- synapse By similarity
Note: Postsynaptic density of neuronal cells.By similarity
Cytosol
- cytosol Source: RGD
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- basal part of cell Source: RGD
- cytoplasm Source: GO_Central
- dendrite Source: GO_Central
- glutamatergic synapse Source: RGD
- postsynaptic density Source: RGD
Keywords - Cellular componenti
Cell junction, Cytoplasm, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191013 | 1 – 358 | Homer protein homolog 3Add BLAST | 358 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 120 | PhosphoserineCombined sources | 1 | |
Modified residuei | 158 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9Z2X5 |
PRIDEi | Q9Z2X5 |
PTM databases
iPTMneti | Q9Z2X5 |
PhosphoSitePlusi | Q9Z2X5 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000020229, Expressed in cerebellum and 20 other tissues |
ExpressionAtlasi | Q9Z2X5, baseline and differential |
Genevisiblei | Q9Z2X5, RN |
Interactioni
Subunit structurei
Tetramer (By similarity). Encodes coiled-coil structures that mediate homo- and heteromultimerization.
Interacts with NFATC2; interaction is calcium independent; interaction competes with PPP3CA for NFATC2 binding; interaction is reduced by AKT activation.
Interacts with NFATC1 and NFATC4.
Interacts with SHANK1; forms a high-order complex at least composed of SHANK1 and HOMER3; the complex formation is regulated by CAMK2A-mediated phosphorylation (By similarity).
By similarityGO - Molecular functioni
- G protein-coupled glutamate receptor binding Source: GO_Central
- identical protein binding Source: RGD
- protein C-terminus binding Source: RGD
- protein domain specific binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 248182, 5 interactors |
IntActi | Q9Z2X5, 5 interactors |
MINTi | Q9Z2X5 |
STRINGi | 10116.ENSRNOP00000027428 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 113 | WH1PROSITE-ProRule annotationAdd BLAST | 113 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 80 | Required for interaction with NFATC2By similarityAdd BLAST | 80 | |
Regioni | 136 – 168 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 239 – 296 | DisorderedSequence analysisAdd BLAST | 58 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 95 – 122 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 190 – 355 | Sequence analysisAdd BLAST | 166 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 249 – 280 | Polar residuesSequence analysisAdd BLAST | 32 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502R3T0, Eukaryota |
GeneTreei | ENSGT00940000158081 |
HOGENOMi | CLU_033940_0_0_1 |
InParanoidi | Q9Z2X5 |
OMAi | KICDLKD |
OrthoDBi | 1251658at2759 |
PhylomeDBi | Q9Z2X5 |
TreeFami | TF325627 |
Family and domain databases
CDDi | cd01206, EVH1_Homer_Vesl, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR045027, Homer IPR044100, Homer_EVH1 IPR011993, PH-like_dom_sf IPR000697, WH1/EVH1_dom |
PANTHERi | PTHR10918, PTHR10918, 1 hit |
Pfami | View protein in Pfam PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI
60 70 80 90 100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFGSEQQLT
110 120 130 140 150
QFAEKFQEVK EAARLAREKS QDGGELTSTA LAMASHQVPP SPLVSTNGPE
160 170 180 190 200
EKLFRSQSAD APGPTERERL KKMLSEGSVG EVQWEAEFFA LQDSNQRLAG
210 220 230 240 250
ALREANAAAT QWRQQLEVQR AEAEHLRQRV AELEAQVAAE PVRAGEKEAT
260 270 280 290 300
SQSVEQLEAR VQTKDQEIQT LKNQSTGPRE APDTAEREET QQQVQDLETR
310 320 330 340 350
NAELEQQLRA MESNLEEARA ERERARAEVG RAAQLLDVRL FELSELREGL
ARLAEAAP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6AH27 | A0A8I6AH27_RAT | Homer protein homolog 3 | Homer3 | 374 | Annotation score: | ||
A0A8I6AJC0 | A0A8I6AJC0_RAT | Homer protein homolog 3 | Homer3 | 445 | Annotation score: | ||
A0A8I6G7E1 | A0A8I6G7E1_RAT | Homer protein homolog 3 | Homer3 | 116 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020879 mRNA Translation: BAA35110.2 |
RefSeqi | NP_445762.1, NM_053310.1 XP_006252953.1, XM_006252891.3 |
Genome annotation databases
GeneIDi | 29548 |
KEGGi | rno:29548 |
UCSCi | RGD:620706, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020879 mRNA Translation: BAA35110.2 |
RefSeqi | NP_445762.1, NM_053310.1 XP_006252953.1, XM_006252891.3 |
3D structure databases
AlphaFoldDBi | Q9Z2X5 |
BMRBi | Q9Z2X5 |
SMRi | Q9Z2X5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 248182, 5 interactors |
IntActi | Q9Z2X5, 5 interactors |
MINTi | Q9Z2X5 |
STRINGi | 10116.ENSRNOP00000027428 |
PTM databases
iPTMneti | Q9Z2X5 |
PhosphoSitePlusi | Q9Z2X5 |
Proteomic databases
PaxDbi | Q9Z2X5 |
PRIDEi | Q9Z2X5 |
Genome annotation databases
GeneIDi | 29548 |
KEGGi | rno:29548 |
UCSCi | RGD:620706, rat |
Organism-specific databases
CTDi | 9454 |
RGDi | 620706, Homer3 |
Phylogenomic databases
eggNOGi | ENOG502R3T0, Eukaryota |
GeneTreei | ENSGT00940000158081 |
HOGENOMi | CLU_033940_0_0_1 |
InParanoidi | Q9Z2X5 |
OMAi | KICDLKD |
OrthoDBi | 1251658at2759 |
PhylomeDBi | Q9Z2X5 |
TreeFami | TF325627 |
Enzyme and pathway databases
Reactomei | R-RNO-6794361, Neurexins and neuroligins |
Miscellaneous databases
PROi | PR:Q9Z2X5 |
Gene expression databases
Bgeei | ENSRNOG00000020229, Expressed in cerebellum and 20 other tissues |
ExpressionAtlasi | Q9Z2X5, baseline and differential |
Genevisiblei | Q9Z2X5, RN |
Family and domain databases
CDDi | cd01206, EVH1_Homer_Vesl, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR045027, Homer IPR044100, Homer_EVH1 IPR011993, PH-like_dom_sf IPR000697, WH1/EVH1_dom |
PANTHERi | PTHR10918, PTHR10918, 1 hit |
Pfami | View protein in Pfam PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
PROSITEi | View protein in PROSITE PS50229, WH1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HOME3_RAT | |
Accessioni | Q9Z2X5Primary (citable) accession number: Q9Z2X5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families