Hnrnpf

Functionⁱ

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).By similarity

GO - Molecular functionⁱ

single-stranded RNA binding Source: UniProtKB
TBP-class protein binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA processing Source: UniProtKB-KW
regulation of RNA splicing Source: UniProtKB
RNA splicing Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6803529 FGFR2 alternative splicing R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-6803529 FGFR2 alternative splicing
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Heterogeneous nuclear ribonucleoprotein F Short name: hnRNP F Cleaved into the following chain: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed
Gene namesⁱ	Name:Hnrnpf Synonyms:Hnrpf
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:2138741 Hnrnpf

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000253053	1 – 415	Heterogeneous nuclear ribonucleoprotein FAdd BLAST	415
Initiator methionineⁱ		Removed; alternateBy similarity
ChainⁱPRO_0000367116	2 – 415	Heterogeneous nuclear ribonucleoprotein F, N-terminally processedAdd BLAST	414

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F, N-terminally processedBy similarity	1
Cross-linkⁱ	72	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	87	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	104	PhosphoserineBy similarity	1
Modified residueⁱ	107	PhosphoserineCombined sources	1
Modified residueⁱ	161	PhosphoserineBy similarity	1
Cross-linkⁱ	167	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	185	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	187	PhosphoserineCombined sources	1
Modified residueⁱ	193	PhosphoserineBy similarity	1
Modified residueⁱ	195	PhosphoserineBy similarity	1
Modified residueⁱ	200	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	200	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	215	PhosphothreonineBy similarity	1
Modified residueⁱ	224	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	224	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	265	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Sumoylated.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9Z2X1
PaxDbⁱ	Q9Z2X1
PeptideAtlas More...PeptideAtlasⁱ	Q9Z2X1
PRIDEⁱ	Q9Z2X1

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	Q9Z2X1

REPRODUCTION-2DPAGEⁱ

Q9Z2X1

PTM databases

iPTMnetⁱ	Q9Z2X1
PhosphoSitePlusⁱ	Q9Z2X1
SwissPalmⁱ	Q9Z2X1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000042079 Expressed in 27 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q9Z2X1 baseline and differential
Genevisibleⁱ	Q9Z2X1 MM

Interactionⁱ

Subunit structureⁱ

Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	16	Interaction with RNABy similarity	1
Siteⁱ	20	Interaction with RNABy similarity	1
Siteⁱ	52	Interaction with RNABy similarity	1
Siteⁱ	75	Interaction with RNABy similarity	1
Siteⁱ	116	Interaction with RNABy similarity	1
Siteⁱ	120	Interaction with RNABy similarity	1
Siteⁱ	150	Interaction with RNABy similarity	1
Siteⁱ	173	Interaction with RNABy similarity	1
Siteⁱ	294	Interaction with RNABy similarity	1
Siteⁱ	298	Interaction with RNABy similarity	1
Siteⁱ	326	Interaction with RNABy similarity	1
Siteⁱ	349	Interaction with RNABy similarity	1

GO - Molecular functionⁱ

TBP-class protein binding Source: MGI
transcription factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	221126, 41 interactors
CORUMⁱ	Q9Z2X1
IntActⁱ	Q9Z2X1, 34 interactors
Molecular INTeraction database More...MINTⁱ	Q9Z2X1
STRINGⁱ	10090.ENSMUSP00000045048

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	3 – 5	Combined sources	3
Beta strandⁱ	12 – 17	Combined sources	6
Helixⁱ	24 – 30	Combined sources	7
Turnⁱ	31 – 33	Combined sources	3
Helixⁱ	39 – 42	Combined sources	4
Beta strandⁱ	43 – 47	Combined sources	5
Beta strandⁱ	49 – 51	Combined sources	3
Beta strandⁱ	53 – 63	Combined sources	11
Helixⁱ	64 – 70	Combined sources	7
Helixⁱ	71 – 73	Combined sources	3
Beta strandⁱ	76 – 78	Combined sources	3
Beta strandⁱ	81 – 88	Combined sources	8
Helixⁱ	90 – 98	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Z2X1
SMRⁱ	Q9Z2X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Z2X1

EvolutionaryTraceⁱ

Q9Z2X1

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	11 – 90	RRM 1PROSITE-ProRule annotationAdd BLAST	80
Domainⁱ	111 – 188	RRM 2PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	289 – 366	RRM 3PROSITE-ProRule annotationAdd BLAST	78

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	81 – 86	Interaction with RNABy similarity	6
Regionⁱ	179 – 184	Interaction with RNABy similarity	6
Regionⁱ	355 – 360	Interaction with RNABy similarity	6

Domainⁱ

The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.By similarity

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4211 Eukaryota ENOG410Z6M0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119102
HOGENOMⁱ	HOG000220896
HOVERGENⁱ	HBG055557
InParanoidⁱ	Q9Z2X1
KEGG Orthology (KO) More...KOⁱ	K12898
OMAⁱ	FLSECKI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CTJ
PhylomeDBⁱ	Q9Z2X1
TreeFamⁱ	TF316157

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR012996 Znf_CHHC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits PF08080 zf-RNPHF, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Z2X1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLGPEGGEG YVVKLRGLPW SCSIEDVQNF LSDCTIHDGV AGVHFIYTRE 
        60         70         80         90        100
GRQSGEAFVE LESEDDVKLA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS 
       110        120        130        140        150
GPNSADSAND GFVRLRGLPF GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK 
       160        170        180        190        200
ITGEAFVQFA SQELAEKALG KHKERIGHRY IEVFKSSQEE VRSYSDPPLK 
       210        220        230        240        250
FMSVQRPGPY DRPGTARRYI GIVKQAGLDR MRSGAYSAGY GGYEEYSGLS 
       260        270        280        290        300
DGYGFTTDLF GRDLSYCLSG MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA 
       310        320        330        340        350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHEE AVAAMSKDRA 
       360        370        380        390        400
NMQHRYIELF LNSTTGASNG AYSSQVMQGM GVSAAQATYS GLESQSVSGC 
       410 
YGAGYSGQNS MGGYD

Length:415

Mass (Da):45,730

Last modified:January 23, 2007 - v3

Checksum:ⁱ31E1C9C90A8E051F

GO

Isoform 2 (identifier: Q9Z2X1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-22: MMLGPEGGEGYVVKLRGLPWSC → MW

« Hide

        10         20         30         40         50
MWSIEDVQNF LSDCTIHDGV AGVHFIYTRE GRQSGEAFVE LESEDDVKLA 
        60         70         80         90        100
LKKDRESMGH RYIEVFKSHR TEMDWVLKHS GPNSADSAND GFVRLRGLPF 
       110        120        130        140        150
GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK ITGEAFVQFA SQELAEKALG 
       160        170        180        190        200
KHKERIGHRY IEVFKSSQEE VRSYSDPPLK FMSVQRPGPY DRPGTARRYI 
       210        220        230        240        250
GIVKQAGLDR MRSGAYSAGY GGYEEYSGLS DGYGFTTDLF GRDLSYCLSG 
       260        270        280        290        300
MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA TENDIYNFFS PLNPVRVHIE 
       310        320        330        340        350
IGPDGRVTGE ADVEFATHEE AVAAMSKDRA NMQHRYIELF LNSTTGASNG 
       360        370        380        390 
AYSSQVMQGM GVSAAQATYS GLESQSVSGC YGAGYSGQNS MGGYD

Show »

Length:395

Mass (Da):43,685

Checksum:ⁱ2EC531A33BA024CF

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3QMT0	J3QMT0_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein F	Hnrnpf	208	Annotation score:
J3QM80	J3QM80_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein F	Hnrnpf	232	Annotation score:
J3QP45	J3QP45_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein F	Hnrnpf	70	Annotation score:
J3QMV8	J3QMV8_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein F	Hnrnpf	31	Annotation score:
J3QNH2	J3QNH2_MOUSE	Heterogeneous nuclear ribonucleopro... Heterogeneous nuclear ribonucleoprotein F	Hnrnpf	14	Annotation score:

Sequence cautionⁱ

The sequence AAH27003 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH29764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC36361 differs from that shown. Reason: Erroneous termination at position 416. Translated as stop.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	272	Y → C in AAH27003 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021004	1 – 22	MMLGP…LPWSC → MW in isoform 2. 1 PublicationAdd BLAST		22

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK076478 mRNA Translation: BAC36361.1 Sequence problems. BC018185 mRNA Translation: AAH18185.1 BC025481 mRNA Translation: AAH25481.1 BC027003 mRNA Translation: AAH27003.1 Different initiation. BC029163 mRNA Translation: AAH29163.1 BC029764 mRNA Translation: AAH29764.1 Different initiation. BC033483 mRNA Translation: AAH33483.1 BC089313 mRNA Translation: AAH89313.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20467.1 [Q9Z2X1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001159899.1, NM_001166427.1 [Q9Z2X1-1] NP_001159900.1, NM_001166428.1 [Q9Z2X1-1] NP_001159901.1, NM_001166429.1 [Q9Z2X1-1] NP_001159902.1, NM_001166430.1 [Q9Z2X1-1] NP_001159903.1, NM_001166431.1 [Q9Z2X1-1] NP_001159904.1, NM_001166432.1 [Q9Z2X1-1] NP_598595.1, NM_133834.2 [Q9Z2X1-1] XP_006506892.1, XM_006506829.3 [Q9Z2X1-1]
UniGeneⁱ	Mm.422979 Mm.476420

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2X1	Heterogeneous nuclear ribonucleoprotein F		RAT		415	UniRef100_Q9Z2X1
Heterogeneous nuclear ribonucleoprotein H		Daphnia magna		415
heterogeneous nuclear ribonucleoprotein F		MESAU		415
Hnrpf protein (Fragment)		MOUSE		188
Heterogeneous nuclear ribonucleoprotein F (Fragment)		MOUSE		208
+4

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2X1	Heterogeneous nuclear ribonucleoprotein F	)	HUMAN		415	UniRef90_P52597
Heterogeneous nuclear ribonucleoprotein F		MACFA		415
Heterogeneous nuclear ribonucleoprotein F		RAT		415
Heterogeneous nuclear ribonucleoprotein F		BOVIN		414
HNRNPF isoform 1		PANTR		415
+129

Protein	Similar proteins		Species	Score	Length	Source
Q9Z2X1	Heterogeneous nuclear ribonucleoprotein F	)	HUMAN		415	UniRef50_P52597
Heterogeneous nuclear ribonucleoprotein F		RAT		415
Heterogeneous nuclear ribonucleoprotein F		MACFA		415
Heterogeneous nuclear ribonucleoprotein F		BOVIN		414
HNRNPF isoform 1		PANTR		415
+180

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK076478 mRNA Translation: BAC36361.1 Sequence problems. BC018185 mRNA Translation: AAH18185.1 BC025481 mRNA Translation: AAH25481.1 BC027003 mRNA Translation: AAH27003.1 Different initiation. BC029163 mRNA Translation: AAH29163.1 BC029764 mRNA Translation: AAH29764.1 Different initiation. BC033483 mRNA Translation: AAH33483.1 BC089313 mRNA Translation: AAH89313.1
CCDSⁱ	CCDS20467.1 [Q9Z2X1-1]
RefSeqⁱ	NP_001159899.1, NM_001166427.1 [Q9Z2X1-1] NP_001159900.1, NM_001166428.1 [Q9Z2X1-1] NP_001159901.1, NM_001166429.1 [Q9Z2X1-1] NP_001159902.1, NM_001166430.1 [Q9Z2X1-1] NP_001159903.1, NM_001166431.1 [Q9Z2X1-1] NP_001159904.1, NM_001166432.1 [Q9Z2X1-1] NP_598595.1, NM_133834.2 [Q9Z2X1-1] XP_006506892.1, XM_006506829.3 [Q9Z2X1-1]
UniGeneⁱ	Mm.422979 Mm.476420

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DB1	NMR	-	A	1-105	[»]
ProteinModelPortalⁱ	Q9Z2X1
SMRⁱ	Q9Z2X1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	221126, 41 interactors
CORUMⁱ	Q9Z2X1
IntActⁱ	Q9Z2X1, 34 interactors
MINTⁱ	Q9Z2X1
STRINGⁱ	10090.ENSMUSP00000045048

PTM databases

iPTMnetⁱ	Q9Z2X1
PhosphoSitePlusⁱ	Q9Z2X1
SwissPalmⁱ	Q9Z2X1

2D gel databases

REPRODUCTION-2DPAGEⁱ	Q9Z2X1

REPRODUCTION-2DPAGEⁱ

Q9Z2X1

Proteomic databases

EPDⁱ	Q9Z2X1
PaxDbⁱ	Q9Z2X1
PeptideAtlasⁱ	Q9Z2X1
PRIDEⁱ	Q9Z2X1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035493; ENSMUSP00000045048; ENSMUSG00000042079 [Q9Z2X1-1] ENSMUST00000163168; ENSMUSP00000130023; ENSMUSG00000042079 [Q9Z2X1-1] ENSMUST00000167182; ENSMUSP00000126817; ENSMUSG00000042079 [Q9Z2X1-1] ENSMUST00000180020; ENSMUSP00000137632; ENSMUSG00000042079 [Q9Z2X1-1] ENSMUST00000180341; ENSMUSP00000136700; ENSMUSG00000042079 [Q9Z2X1-1]
GeneIDⁱ	98758
KEGGⁱ	mmu:98758
UCSCⁱ	uc009dle.2 mouse [Q9Z2X1-1]

Organism-specific databases

CTDⁱ	3185
MGIⁱ	MGI:2138741 Hnrnpf

Phylogenomic databases

eggNOGⁱ	KOG4211 Eukaryota ENOG410Z6M0 LUCA
GeneTreeⁱ	ENSGT00760000119102
HOGENOMⁱ	HOG000220896
HOVERGENⁱ	HBG055557
InParanoidⁱ	Q9Z2X1
KOⁱ	K12898
OMAⁱ	FLSECKI
OrthoDBⁱ	EOG091G0CTJ
PhylomeDBⁱ	Q9Z2X1
TreeFamⁱ	TF316157

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6803529 FGFR2 alternative splicing R-MMU-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-MMU-6803529 FGFR2 alternative splicing
R-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	Hnrnpf mouse
EvolutionaryTraceⁱ	Q9Z2X1
Protein Ontology More...PROⁱ	PR:Q9Z2X1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042079 Expressed in 27 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q9Z2X1 baseline and differential
Genevisibleⁱ	Q9Z2X1 MM

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR012996 Znf_CHHC
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits PF08080 zf-RNPHF, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HNRPF_MOUSE
Accessionⁱ	Q9Z2X1Primary (citable) accession number: Q9Z2X1 Secondary accession number(s): Q5FWK2 , Q8BVU8, Q8K2U9, Q8R0E7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 169 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Z2X1 (HNRPF_MOUSE)

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Heterogeneous nuclear ribonucleoprotein F

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ