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UniProtKB - Q9Z2X1 (HNRPF_MOUSE)

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Protein

Heterogeneous nuclear ribonucleoprotein F

Gene

Hnrnpf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-6803529 FGFR2 alternative splicing
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein F
Short name:
hnRNP F
Cleaved into the following chain:
Heterogeneous nuclear ribonucleoprotein F, N-terminally processed
Gene namesi
Name:Hnrnpf
Synonyms:Hnrpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2138741 Hnrnpf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002530531 – 415Heterogeneous nuclear ribonucleoprotein FAdd BLAST415
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00003671162 – 415Heterogeneous nuclear ribonucleoprotein F, N-terminally processedAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein F, N-terminally processedBy similarity1
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei104PhosphoserineBy similarity1
Modified residuei107PhosphoserineCombined sources1
Modified residuei161PhosphoserineBy similarity1
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei187PhosphoserineCombined sources1
Modified residuei193PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Modified residuei200N6-acetyllysine; alternateCombined sources1
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei215PhosphothreonineBy similarity1
Modified residuei224N6-acetyllysine; alternateBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei265PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Z2X1
PaxDbiQ9Z2X1
PeptideAtlasiQ9Z2X1
PRIDEiQ9Z2X1

2D gel databases

REPRODUCTION-2DPAGEiQ9Z2X1

PTM databases

iPTMnetiQ9Z2X1
PhosphoSitePlusiQ9Z2X1
SwissPalmiQ9Z2X1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042079
ExpressionAtlasiQ9Z2X1 baseline and differential
GenevisibleiQ9Z2X1 MM

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with AGO1, AGO2, TBP and TXNL4/DIM1 (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei16Interaction with RNABy similarity1
Sitei20Interaction with RNABy similarity1
Sitei52Interaction with RNABy similarity1
Sitei75Interaction with RNABy similarity1
Sitei116Interaction with RNABy similarity1
Sitei120Interaction with RNABy similarity1
Sitei150Interaction with RNABy similarity1
Sitei173Interaction with RNABy similarity1
Sitei294Interaction with RNABy similarity1
Sitei298Interaction with RNABy similarity1
Sitei326Interaction with RNABy similarity1
Sitei349Interaction with RNABy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi221126, 40 interactors
CORUMiQ9Z2X1
IntActiQ9Z2X1, 34 interactors
MINTiQ9Z2X1
STRINGi10090.ENSMUSP00000045048

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi12 – 17Combined sources6
Helixi24 – 30Combined sources7
Turni31 – 33Combined sources3
Helixi39 – 42Combined sources4
Beta strandi43 – 47Combined sources5
Beta strandi49 – 51Combined sources3
Beta strandi53 – 63Combined sources11
Helixi64 – 70Combined sources7
Helixi71 – 73Combined sources3
Beta strandi76 – 78Combined sources3
Beta strandi81 – 88Combined sources8
Helixi90 – 98Combined sources9

3D structure databases

ProteinModelPortaliQ9Z2X1
SMRiQ9Z2X1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Z2X1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini289 – 366RRM 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni81 – 86Interaction with RNABy similarity6
Regioni179 – 184Interaction with RNABy similarity6
Regioni355 – 360Interaction with RNABy similarity6

Domaini

The N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiQ9Z2X1
KOiK12898
OMAiFLSECKI
OrthoDBiEOG091G0CTJ
PhylomeDBiQ9Z2X1
TreeFamiTF316157

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Z2X1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLGPEGGEG YVVKLRGLPW SCSIEDVQNF LSDCTIHDGV AGVHFIYTRE 
        60         70         80         90        100
GRQSGEAFVE LESEDDVKLA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS 
       110        120        130        140        150
GPNSADSAND GFVRLRGLPF GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK 
       160        170        180        190        200
ITGEAFVQFA SQELAEKALG KHKERIGHRY IEVFKSSQEE VRSYSDPPLK 
       210        220        230        240        250
FMSVQRPGPY DRPGTARRYI GIVKQAGLDR MRSGAYSAGY GGYEEYSGLS 
       260        270        280        290        300
DGYGFTTDLF GRDLSYCLSG MYDHRYGDSE FTVQSTTGHC VHMRGLPYKA 
       310        320        330        340        350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHEE AVAAMSKDRA 
       360        370        380        390        400
NMQHRYIELF LNSTTGASNG AYSSQVMQGM GVSAAQATYS GLESQSVSGC 
       410 
YGAGYSGQNS MGGYD
Length:415
Mass (Da):45,730
Last modified:January 23, 2007 - v3
Checksum:i31E1C9C90A8E051F
GO
Isoform 2 (identifier: Q9Z2X1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MMLGPEGGEGYVVKLRGLPWSC → MW

Show »
Length:395
Mass (Da):43,685
Checksum:i2EC531A33BA024CF
GO

Sequence cautioni

The sequence AAH27003 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH29764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC36361 differs from that shown. Reason: Erroneous termination at position 416. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272Y → C in AAH27003 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210041 – 22MMLGP…LPWSC → MW in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076478 mRNA Translation: BAC36361.1 Sequence problems.
BC018185 mRNA Translation: AAH18185.1
BC025481 mRNA Translation: AAH25481.1
BC027003 mRNA Translation: AAH27003.1 Different initiation.
BC029163 mRNA Translation: AAH29163.1
BC029764 mRNA Translation: AAH29764.1 Different initiation.
BC033483 mRNA Translation: AAH33483.1
BC089313 mRNA Translation: AAH89313.1
CCDSiCCDS20467.1 [Q9Z2X1-1]
RefSeqiNP_001159899.1, NM_001166427.1 [Q9Z2X1-1]
NP_001159900.1, NM_001166428.1 [Q9Z2X1-1]
NP_001159901.1, NM_001166429.1 [Q9Z2X1-1]
NP_001159902.1, NM_001166430.1 [Q9Z2X1-1]
NP_001159903.1, NM_001166431.1 [Q9Z2X1-1]
NP_001159904.1, NM_001166432.1 [Q9Z2X1-1]
NP_598595.1, NM_133834.2 [Q9Z2X1-1]
XP_006506892.1, XM_006506829.3 [Q9Z2X1-1]
UniGeneiMm.422979
Mm.476420

Genome annotation databases

EnsembliENSMUST00000035493; ENSMUSP00000045048; ENSMUSG00000042079 [Q9Z2X1-1]
ENSMUST00000163168; ENSMUSP00000130023; ENSMUSG00000042079 [Q9Z2X1-1]
ENSMUST00000167182; ENSMUSP00000126817; ENSMUSG00000042079 [Q9Z2X1-1]
ENSMUST00000180020; ENSMUSP00000137632; ENSMUSG00000042079 [Q9Z2X1-1]
ENSMUST00000180341; ENSMUSP00000136700; ENSMUSG00000042079 [Q9Z2X1-1]
GeneIDi98758
KEGGimmu:98758
UCSCiuc009dle.2 mouse [Q9Z2X1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHNRPF_MOUSE
AccessioniPrimary (citable) accession number: Q9Z2X1
Secondary accession number(s): Q5FWK2
, Q8BVU8, Q8K2U9, Q8R0E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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